Analyzing Carbohydrates on Therapeutic Glycoproteins
Spectroscopy E-Books
A very important component of the characterization of therapeutic proteins is the analysis of the carbohydrate structures that are attached to them. Those carbohydrates play an important role in ensuring the safety and efficacy of these drugs, and are an important consideration when comparing a candidate biosimilar drug to its reference product. For advice on this topic,
LCGC
spoke to Parastoo Azadi, PhD, the technical director for analytical services at the University of Georgia Complex Carbohydrate Research Center. Read more
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AI and Dual-Sensor Spectroscopy Supercharge Antibiotic Fermentation
June 30th 2025Researchers from Chinese universities have developed an AI-powered platform that combines near-infrared (NIR) and Raman spectroscopy for real-time monitoring and control of antibiotic production, boosting efficiency by over 30%.
Toward a Generalizable Model of Diffuse Reflectance in Particulate Systems
June 30th 2025This tutorial examines the modeling of diffuse reflectance (DR) in complex particulate samples, such as powders and granular solids. Traditional theoretical frameworks like empirical absorbance, Kubelka-Munk, radiative transfer theory (RTT), and the Hapke model are presented in standard and matrix notation where applicable. Their advantages and limitations are highlighted, particularly for heterogeneous particle size distributions and real-world variations in the optical properties of particulate samples. Hybrid and emerging computational strategies, including Monte Carlo methods, full-wave numerical solvers, and machine learning (ML) models, are evaluated for their potential to produce more generalizable prediction models.
