Appendix XII: Terahertz
Additional information from the terahertz section of the Pittcon Review article.
Manufacturer: Advantest America Inc
Product name: TAS7500
Terahertz Spectroscopy/Imaging System
New this year: Polarization Accessory, extended range spectrometer option, sub terahertz spectrometer option, new emitter and detector modules, high sensitivity in crystallinity application.
Used for: Lab, process analysis
Available as separate product, 21CFR11 compliant, May be used in other equipment, Compatible with other manufacturers' equipment
Special Features: Custom sample holders and extended range emitter and detector
Measurement Mode: TeraHertz transmission, reflection, Polarization, Imaging, ATR
Features: Modular compact benchtop spectroscopy and imaging system. individual measurement units for spectroscopy and 2D/3D imaging can be combined as a fully configured system or purchased separately as an upgrade. Terahertz waves penetrate the entire tablet core and detect cracks and voids that result from capping or chipping during compression. Sensitive to vibrational lattice phonon modes characteristic of crystalline solids (e.g., polymorphs, solvates and co-crystals) in drug substances and in drug products.
Special Features: highest speed and reliability in the industry
Software: Imaging Software, Spectroscopy Software, High Throughput Data Analysis Software, 21 CFR Part 11 Compliant Software
Suggested applications: crystalline structure, 3D images, tablet coating thickness and uniformity, non-destructive detection of cracks and voids in the tablet core, solid phase transitions, replacement for mercury porosimetry
Primary benefits: faster operation, wider wavelength range, greater dynamic range
Unique features: 8-millisecond scan time
Manufacturer: BrightSpec
Product name: Brightspec ONE Broadband CP-FT
Rotational Spectrometer (Sub-Terahertz Gas phase Analysis)
New this year: brand new company and product
Used for: Lab and Process analysis
Dimensions: Luggable not portable
Measurement Mode: Emission
Suggested applications: purity of specialty samples, composition of complex mixtures.
Special Features: Ultra-high resolution and quantum nature of the measurements over large spectral bandwidth utilizes high-speed digital electronics, highly agile frequency generation method to improve confidence in detections. Solid-state digital electronics used for frequency generation and accuracy instead of traditional optics, eliminates the need for chemical separation when analyzing mixtures, broad operating frequency range, has near zero background
Software: Included. May be used in other equipment, compatible with other manufacturers' equipment
Primary benefits: simultaneous monitoring of molecules with energy transitions in different spectral regions, spectral line redundancies improves confidence of molecular assignment, trace level quantification.
Manufacturer: BrightSpec
Product name: Brightspec Targeted Band CP-FT
Gas phase Analyzer
New this year: brand new company and product
Used for: Lab and Process analysis
Dimensions: Luggable, not portable
Measurement Mode: Emission
Software: Included. May be used in other equipment, compatible with other manufacturers' equipment
Special Features: Same as Brightspec ONE, except uses narrow frequency sweep, Ultra-high resolution, Zero Background, Multiple compounds can be surveyed in a sequential fashion, 10x better sensitivity than the Broadband, programmable for additional species within its specific operating range
Suggested Applications: identification and quantification of known, previously characterized analytes,.
Suggested applications: same as Brightspec ONE.
Primary benefits: 10x sensitivity compared to Brightspec ONE
Unique features worthy of mention: PPM or PPB sensitivities achievable in under one second
Getting accurate IR spectra on monolayer of molecules
April 18th 2024Creating uniform and repeatable monolayers is incredibly important for both scientific pursuits as well as the manufacturing of products in semiconductor, biotechnology, and. other industries. However, measuring monolayers and functionalized surfaces directly is. difficult, and many rely on a variety of characterization techniques that when used together can provide some degree of confidence. By combining non-contact atomic force microscopy (AFM) and IR spectroscopy, IR PiFM provides sensitive and accurate analysis of sub-monolayer of molecules without the concern of tip-sample cross contamination. Dr. Sung Park, Molecular Vista, joined Spectroscopy to provide insights on how IR PiFM can acquire IR signature of monolayer films due to its unique implementation.
