Pittcon Review, Appendix V: Mass Spectrometry
Additional information from the mass spectrometry section of the Pittcon Review article.
Manufacturer: 1st Detect
Product name: MMS-1000
Product type: Mass spectrometer
For: Laboratory and process analysis
Portable: 6 x 12 x 8 in.
Accessories available: Preconcentrator, thermal desorber
Measurement mode: Ion trap
Special features: Affordable, small benchtop footprint, fast analysis, wide mass range, high sensitivity, high resolution
Suggested applications: Laboratory research, process control, pharmaceutical, petrochemical, teaching aid, classroom, food and beverage manufacturing, forensics
Primary benefits: Laboratory quality analysis
Manufacturer: Advion
Product name: Expression CMS
Compact Mass Spectrometer
Description: Personal single-pole quadrupole mass spectrometer, compact enough to operate in fume hoods and space-restricted laboratories
Manufacturer: Agilent Technologies
Product name: Agilent 8800 Triple Quadrupole ICP-MS (ICP-QQQ)
For: Laboratory analysis
Special features: The only triple-quadrupole ICP-MS system. The 8800 ICP-QQQ has higher sensitivity and lower backgrounds. This configuration enables MS-MS operation, providing precise control of reaction processes. MS-MS capability also enables several unique measurement modes and eliminates problematic interferences.
Software: 21CFR11 compliant, cGMP compliant, may be used in other equipment.
Suggested applications: Elemental analysis across all applications, low-level analysis of sulfur and phosphorus.
Unique features: Industry-leading matrix tolerance with Agilent's HMI technology; MS-MS capability permits controlled reaction chemistry
Manufacturer: Bruker Corporation
Product name: SCION TQ gas chromatograph–mass spectrometer
For: Laboratory analysis
New this year: Flow-through design, axial source, lens-free design, compound based scanning with MRM library, EDR detector
Special features: Increased robustness, reduced tuning and system maintenance, faster method development, increased dynamic range and reduced inter-scan delay.
Software: Available as separate product, 21CFR11 compliant, cGMP compliant, compatible with other manufacturers' equipment.
Primary benefits: Compound-based scanning, simplified set up, fast scanning, increased accuracy of assays, reduces tuning and maintenance of system.
Suggested applications: Food testing: pesticide residues and adulterants; priority pollutants: PCBs and PBBs; forensic/toxicology: drugs of abuse in hair; sports medicine: doping, steroids, or performance enhancing agents; sourcing of petroleum biomarkers
Manufacturer: Ionicon Analytik GmbH
Product name: High-Sensitivity PTR-QMS 500 mass spectrometer (PTR-MS, proton transfer reaction mass spectrometer)
New this year: Launch of new quadrupole-based series, completely reengineered instrument generation.
For: Laboratory and process analysis
Primary benefits: Detection limit < 1 pptv, ultra high sensitivity, response time down to 100 ms; measure with high resolution in real-time
Unique features: Analysis of entire mass range in a split second, no sample preparation necessary, direct air sampling.
Suggested applications: Low-concentration (pptv-range) volatile organic compounds (VOCs) for environmental research (atmospheric chemistry, BTEX, BVOC studies), food and flavor science (aroma, fragrance and flavor quantification), illicit substances and explosives detection.
Manufacturer: Ionicon Analytik GmbH
Product name: PTR-QMS 300 mass spectrometer
New this year: Updated software and solution portfolio based on the PTR-QMS 300 platform.
For: Laboratory and process analysis
Primary benefits: Small, lightweight, easily transportable, short start-up time and real-time VOC detection with a detection limit of < 0.5 ppbv
Unique features: Entire mass range analysis in split-second, no sample preparation necessary, direct air sampling.
Suggested applications: Process monitoring, mobile deployment, and customized monitoring solutions
Manufacturer: Ionicon Analytik GmbH
Product name: PTR-TOF 8000 mass spectrometer
For: Laboratory analysis
New this year: Improved sensitivity and detection limit by one order of magnitude.
Primary benefits: Mass resolution up to 8000, response time of 100 ms and detection limit in the single-digit pptv-range with a high resolution in real-time
Unique features: Separation of isobaric compounds, entire mass range analysis in a split second, no sample preparation necessary, direct air sampling.
Suggested applications: Low-concentration (pptv-range) volatile organic compounds (VOCs). Used in environmental research (atmospheric chemistry, BTEX, BVOC studies), food and flavor science (aroma, fragrance and flavor quantification), detection of illicit substances and explosives.
Manufacturer: Ionics
Product name: Triple Quadrupole MS
Description: Triple-Quadrupole GC–MS-MS system
Manufacturer: Livermore Instruments, Inc.
Product name: SPAMS 3.0
(single particle aerosol mass spectrometer)
For: Laboratory & Process
New this year: It is being made available to end-users.
Measurement mode: The SPAMS 3.0 draws in single particles, determines their size, and collects a dual-polarity mass spectrum from each individual one; measuring many per second in real time.
Special features: SPAMS instruments inherently can be used in the field.
Primary benefits: Can determine the size and chemical composition of aerosol particles and automatically interpret that data in real-time.
Unique features: A SPAMS 3.0 can process a range of particles sized from 100 nm to 30 μm.
Manufacturer: nanoLiter, LLC
Product name: nanoLiter Cool Wave X
Mass spectrometer and other sample input, placement device.
For: Laboratory and Process analysis
Description: Can print liquids for MS or ATIR, other.
Special features: Transfers 100% of liquid samples into mass spectrometers or other instruments.
Software:21CFR11 compliant, cGMP compliant, may be used in other equipment, Compatible with other manufacturers' equipment
Suggested applications: Mass spectrometry, ESI proteomics, MALDI bacteria characterizations per NIH work, SIMS, LDI, DART, and DESI.
Primary benefits: 10–100X increase in sensitivity, allows making spatially tight concentrations of depositions for ATIR and other forms of spectroscopy including MALDI, SIMS, DART and DESI.
Manufacturer: Netzsch Instruments North America, LLC
www.netzsch-thermal-analysis.com
Product name: STA-GC-MS
GC–MS system coupled to simultaneous TGA-DSC
For: laboratory analysis
New this year: Thermo gravimetric analyzer connected to GC–MS
Suggested applications: Evolved gas analysis of polymers, pharmaceuticals, and foods
Primary benefits: Separation of compounds in evolved gas prior to analysis with MS
Unique features: TGA of TG-GC–MS system can be equipped with automatic sample changer.
Manufacturer: Thermo Fisher Scientific
Product name: Thermo Scientific iCAP Q ICP-MS
For: Lab analysis
New this year: User-inspired design, interference removal technology, increased throughput, robust
Accessory/component: Autosampler enclosure, LC/IC/GC coupling, autosamplers and others
Measurement mode: Mass spectrometry
Suggested applications: Environment, food safety, semiconductor, pharma, reasearch, geochem
Primary benefits: Ease of use, throughput, performance, reliability
Unique features: New skimmer cone insert technology, QCell collision cell with flatapole technology
Manufacturer: Waters Corporation
Product name: Waters SQ Detector 2
Single-quadrupole MS detector
For: Lab analysis
New this year: The SQ Detector 2 is Waters' newest single-quadrupole mass detector.
Description: Wide mass range (3000 m/z), 15000 Da/s scan speed, compatible with the Waters Universal Ionization Source platform, UPLC, HPLC, GC, preparative HPLC, and Waters UPC2, ZSpray technology
Accessory/component: wide range of ionization modes including ESI, APCI, ESCi, nanoFlow ESI, TRIZAIC, ASAP, APPI and APGC, DESI, DART, and LDTD.
Measurement mode: Typically used as an LC–MS system and autopurification system
Special features: Ease of use, robustness and reliability, versatility, designed for compatibility with chromatographic and nonchromatographic analyses.
Software: MassLynx MS software, available as separate product, 21CFR11-compliant ready, cGMP compliant ready,
Suggested applications: Routine qualitative and quantitative applications within the pharmaceutical, chemical materials, food safety and environmental industries for both small and large molecule applications.
Primary benefits: a mass detection system that is easy to use and gives consistent, reliable results.
Unique features: Enables LC–MS, SFC–MS, GC–MS, and direct sample analysis
Manufacturer: Waters Corporation
Product name: Waters Synapt G2-S high-definition MS system
Hybrid orthogonal acceleration time-of-flight mass spectrometer
For: Lab analysis
New this year: Has both StepWave ion transfer optics and Triwave ion mobility technologies
Special features: 30X improvement in signal intensity, 5X improvement in signal-to-noise, and 10-fold improvement in limits of quantitation over previous-generation mass spectrometers. Combines high-resolution MS-MS with high-efficiency ion-mobility spectroscopy.
Accessory/Component: High-Definition MSE acquisition method in proteomics studies, five orders of magnitude dynamic range.
Suggested applications: Proteomics, metabolomics, lipidomics, drug discovery and development, polymers, petrols, imaging, food and environmental studies, biomarker discovery.
Unique features: Comprehensive MSE data acquisition, T-wave ion mobility separations,
Manufacturer: Waters Corporation
Product name: Waters Xevo TQD
Tandem quadrupole mass spectrometer for routine quantitative LC–MS-MS analyses.
For: Lab applications
New this year: This is the newest addition to Waters' Xevo family of tandem quadrupole mass spectrometers
Accessory/component: Wide range of ionization modes: ESI, APCI, ESCi, nanoFlow ESI, TRIZAIC, ASAP, APPI, and APGC.
Description: Typically used as a UPLC–MS-MS system
Special features: TQD features RADAR technology. RADAR technology is a data acquisition approach that allows scientists to monitor for matrix interferences, metabolites, impurities, and degradants in their samples while accurately quantifying their target compounds.
Software: MassLynx MS software
21CFR11-compliant ready, cGMP-compliant ready,
Suggested applications: Routine quantitative applications, robustness, reliability, and ease of use are the primary objectives. Many of these applications are within the chemical materials, environmental, food safety, and pharmaceutical industries.
Unique features: Collision cell technology, Rapid polarity switching
Getting accurate IR spectra on monolayer of molecules
April 18th 2024Creating uniform and repeatable monolayers is incredibly important for both scientific pursuits as well as the manufacturing of products in semiconductor, biotechnology, and. other industries. However, measuring monolayers and functionalized surfaces directly is. difficult, and many rely on a variety of characterization techniques that when used together can provide some degree of confidence. By combining non-contact atomic force microscopy (AFM) and IR spectroscopy, IR PiFM provides sensitive and accurate analysis of sub-monolayer of molecules without the concern of tip-sample cross contamination. Dr. Sung Park, Molecular Vista, joined Spectroscopy to provide insights on how IR PiFM can acquire IR signature of monolayer films due to its unique implementation.
Achieving Accurate IR Spectra On Monolayer of Molecules
April 18th 2024Creating uniform and repeatable monolayers is incredibly important for both scientific pursuits as well as the manufacturing of products in semiconductor, biotechnology, and. other industries. However, measuring monolayers and functionalized surfaces directly is. difficult, and many rely on a variety of characterization techniques that when used together can provide some degree of confidence. By combining non-contact atomic force microscopy (AFM) and IR spectroscopy, IR PiFM provides sensitive and accurate analysis of sub-monolayer of molecules without the concern of tip-sample cross contamination. Dr. Sung Park, Molecular Vista, joined Spectroscopy to provide insights on how IR PiFM can acquire IR signature of monolayer films due to its unique implementation.
