Pittcon Review, Appendix VIII: Raman

May 1, 2012

Additional information from the Raman section of the Pittcon Review article.

Manufacturer: BaySpec, Inc.

www.bayspec.com

Product name: MovingLab

Raman microscope

For: Lab and process applications

Portable: 305 x 305 x 381 mm3

Measurement mode: Raman

Description: Variety of microscope objectives and XYZ stages are available.

Special features: On-board swivel screen, Windows-based Netbook PC, back up lithium ion battery

Software: Available as separate product, 21CFR11 compliant, cGMP compliant, used in other equipment, compatible with other manufacturers' equipment

Suggested applications: ID of narcotics and drugs, explosives, and CWA ID, hazardous materials, chemicals, pharmaceutical QC, and gemstone authentication.

Primary benefits: No moving parts, portable Raman microscope, transfer libraries

Unique features: Available in 532-, 785-, and 1064-nm excitation wavelengths

Manufacturer: BaySpec, Inc.

www.bayspec.com

Product name: Nomadic

Raman Microscope

For: Lab analysis

Portable: 820 (W) x 410 (D) x 680 (H) mm3

Measurement mode: Raman microscope

Description: Variety of microscope objectives, XYZ stages

Software: (same features as above)

Suggested applications: (same applications as above)

Primary benefits: No moving parts, three simultaneous excitation wavelengths (532, 785, and 1064 nm), ask about other wl options

Manufacturer: BaySpec, Inc.

www.bayspec.com

Product name: RamSpec-HR-1064

High resolution Raman instrument

For: Lab and process applications

Portable: 432 x 305 x 178 mm3

Measurement mode: Raman

Description: variety of probes available

Special features: On-board swivel screen Windows-based Netbook PC

Software: (same as above)

Suggested applications: (same as above)

Primary benefits: High ~4–5 cm-1 spectral resolution for the range of 200–3200 cm-1

Unique features: Available in 532-, 785-, and 1064-nm excitation wavelengths

Manufacturer: BioTools, Inc.

www.btools.com

Product name: u-BioRAMAN

Portable integrated micro-imaging-Raman spectrometer

For: Laboratory analysis

Portable: 14 in. length x 11 in. high, approx. 10 lb.

Measurement mode: Transmission and microscopy

Description: Solid and liquid sampling accessory included; microscopy and visible imaging

Special features: The first portable microscope, easy translation between measurement modes — solids and liquids or visible and Raman. Built-in microscope

Suggested applications: Biopharmaceutical — specially designed for protein structure elucidation and comparability studies; pharmaceutical drug analysis; forensic analysis; polymers; geology; and semiconductor.

Primary benefits: Provides very high sensitivity. Specifically designed for biological samples — includes programs for structure elucidation and database of Raman spectra of proteins in solid and solution states.

Unique features: Attractive features include small size and light weight, ease of use and ability to obtain Raman and visual microscopic images of solids and ordinary Raman of biosolutions in quartz cuvettes with high signal quality and resolution.

Manufacturer: B&W Tek, Inc.

www.bwtek.com

Product name: NanoRam

Available as: Handheld Raman spectrometer

For: Handheld applications

Portable: 9 x 4.125 x 2.25 in.

Measurement mode: Raman scatter

Special accessoryDescription: Sampling Attachments: point and shoot, vial holder, right angle

Special features: Portable, compact, battery powered, 21CFR11 compliant, cGMP compliant.

Suggested applications: Incoming material identification and verification, at-line sampling and final inspection, and counterfeit drug detection

Primary benefits: Rapid validation and deployment within cGMP facilities is made possible by the combination of near-laboratory grade Raman spectral analysis together with validated methods and libraries.

Unique features: TE cooled detector, VBG stabilized laser, API spectral library comes standard, Wi-Fi and USB communications, portable, wireless interface with iPads and other tablet PCs, 2900-cm-1 spectral range

Manufacturer: DeltaNu, a business unit of Intevac Photonics

www.deltanu.com

Product name: PHARMA•ID

Hand-held Raman spectrometer

New this year: Pass/Fail analysis, 21 CFR Part 11 compliant, CAMO Unscrambler-X software package, BlueTooth bar-code scanner

Portable: 5.25 x 2.5 x 1.5 in. (13.5 x 6.5 x 4 cm)

Special features: Smallest handheld Raman available.

Suggested applications: Pharmaceutical identification

Manufacturer: DeltaNu, a business unit of Intevac Photonics

www.deltanu.com

Product name: DeltaNu Advantage Series

Raman spectrometer

For: Laboratory analysis

New this year: improved specifications

Software: NuSpec software, CAMO Unscrambler-X, Grams software

Suggested applications: University teaching labs, research and development

Primary benefits: High performance in a low-cost system

Unique features: Available with 532 nm, 633 nm, 785 nm, and 1064 nm

Manufacturer: Enwave Optronics, Inc.

www.enwaveopt.com

Product name: EZRaman-H-G4 Handheld Raman analyzer

GasRaman-NOCH2 field-portable multiple gas analyzer

For: Lab, handheld analysis

Portable: 9 x 9 x 4 in.; 5.5 lb

Measurement mode: Reflection

Special features: GasRaman-NOCH2 is a fully integrated, battery-powered, and portable multi-gas analyzer for the measurement of high PPM to percentage range of gases.

Accessory description: Bar-code scanner, tablet (pill) holder, flow through gas sampler

21CFR11 compliant, cGMP compliant

Suggested applications: Pharmaceutical incoming raw material identification, plastic recycling, security/forensics, field multiple-gas analysis

Primary benefits: High sensitivity Raman measurements with handheld packaging

Unique features: Desktop lab instrument sensitivity in handheld format

Manufacturer: Hamamatsu Corporation

sales.hamamatsu.com

Product name: C11714CA Raman mini-spectrometer

Available as: Raman spectrometer

For: Laboratory analysis

Measurement mode: Reflection

Special features: Miniature spectrometer with built-in CCD image sensor and optics, 790–920 nm sensitivity, 0.3-nm spectral resolution, 1024 pixels, compact size (120 x 70 x 60 mm)

Suggested applications: Raman spectroscopy

Primary benefits: High-sensitivity measurements and compact size

Unique features: The C11714CAs built-in CCD has low etaloning characteristics, ensuring optimum detector performance.

Manufacturer: Horiba Scientific – OEM Division

www.horiba.com/MiniCCT+ or www.oemraman.com

Product name: Mini-CCT+ miniature Raman spectrometer

Raman spectrometer

For: Lab, process, handheld applications

New this year: Unmatched 7000:1 dynamic range back-illuminated CCD for high end OEM applications.

Portable: 2.5 × 4 × 1.6 in. (63.5 × 101.6 × 40.6 mm)

Accessory/component: SMA fiber-optic coupling and USB-2 high speed interface

Measurement mode: Raman emission

Special features: Miniaturized for handheld applications

Suggested applications: Homeland security, medical, biotechnology

Primary benefits: High throughput (f/3.1); new tall back-illuminated CCD with high dynamic range.

Unique features: Outperforms current mini-spectrometers based on front-illuminated CCDs, or low-cost back-illuminated CCDs.

Manufacturer: Mustard Tree Instruments

www.mustardtree.com

Product name: VerifierR Process System 1000

Raman spectrometer

For: Process analysis

Transportable: Weight is approximately 12 lb

Accessories: Attaches to pipes, tanks, and reactors, tubing or flow cells.

Measurement mode: Raman scattering

Special features: Environmentally rated for IP67 and NEMA 6

Software:21CFR11 compliant, cGMP compliant, may be used in other equipment, compatible with other manufacturers' equipment

Suggested applications: Purity, chemical ID, mixture analysis, concentration analysis of mixtures, reaction completion.

Primary benefits: Rapid method development, Rapid set ups

Unique features: Limits of detection at or below 1%, adaptive lens technology automatically optimizes S/N.

Manufacturer: Real-Time Analyzers

www.rta.biz

Product name: SERS-Lab 785

Dispersive 785-nm Raman spectrometer with integrated 96-well plate reader

For: Lab applications

Suggested applications: Surface-enhanced Raman spectroscopy (SERS) for trace chemical detection, normal Raman.

Special features: Sol-gel based SERS coatings on the following substrates: 2-mL vials, capillaries, 96-well microplates). The robotic plate reader contains accessories for 2-mL sample vials, capillaries, and active 96-well microplates.

Primary benefits: High performance dispersive 785 nm for high throughput screening. Automated sampling for multiple samples or for mapping of individual samples.

Unique features: Optimized for our proprietary SERS substrates with gold or silver nanoparticles.

Manufacturer: Renishaw plc

www.renishaw.com/raman

Product name: RA800-series OEM benchtop instruments

Raman Spectrometer

For: Lab analysis

New this year: Brand new product, aimed at commercial partners

Measurement mode: Backscattered Raman

Description: Customized for each OEM; enables OEM to offer their customers research grade Raman microscopy performance in a Class 1 laser safe, simple to use system.

Suggested applications: Any requiring rapid Raman analysis, especially imaging. Simplicity and ease of use make the RA800-series ideally suited for routine use in laboratories, QA/QC, and at-line.

Unique features: Innovative technology results in very rapid data collection of high resolution Raman spectra and images. Can be provided in a range of configurations, with different excitation wavelength, spectral coverage, sample handling, and software.

Manufacturer: Rigaku Raman Technologies

www.rigakuraman.com

Product name: Xantus-2 dual-wavelength handheld Raman analyzer

For: Lab, process, handheld applications

New this year: World's first dual-wavelength handheld Raman analyzer. Designed specifically to overcome the intrinsic fluorescence issues found in many materials

Portable: 138 X 274 X 98 mm (WxDxH) (8.1 lb)

Special features: Portable, battery powered, open spectral library, two analyzers in one box

Suggested applications: In-line pharmaceutical processing, authentication, anti-counterfeiting, explosive and chemical warfare agents, hazardous and chemical spills, RFAW material raw ID, narcotics and illicit street drugs.

Primary benefits: Only company that offers 1064-nm excitation source

Unique features: Two analyzers in one with 1064- and 785-nm excitation sources, open spectral library, no sample prep, cooled detectors for better sensitivity

Manufacturer: Thermo Fisher Scientific

www.thermoscientific.com/trunarc

Product name: Thermo Scientific TruNarc

Product type: Raman Spectrometer

New this year: Thermo Scientific TruNarc analyzer

Portable: 6.4 x 4.1 x 2.0 in. (16.26 x 10.41 x 5.1 cm), weighs just 1.25 lb (570g)

Special features: Nondestructive, noncontact testing preserves evidence; automated data storage and report generation; lightweight, handheld analyzer.

Suggested applications: Narcotics identification for law enforcement, customs, border patrol

Unique features: Library can be updated to include new threats, includes Reachback feature, enabling user to reach a spectroscopist 24/7/365 for advanced questions.