Pittcon Review, Appendix VIII: Raman
Additional information from the Raman section of the Pittcon Review article.
Manufacturer: BaySpec, Inc.
Product name: MovingLab
Raman microscope
For: Lab and process applications
Portable: 305 x 305 x 381 mm3
Measurement mode: Raman
Description: Variety of microscope objectives and XYZ stages are available.
Special features: On-board swivel screen, Windows-based Netbook PC, back up lithium ion battery
Software: Available as separate product, 21CFR11 compliant, cGMP compliant, used in other equipment, compatible with other manufacturers' equipment
Suggested applications: ID of narcotics and drugs, explosives, and CWA ID, hazardous materials, chemicals, pharmaceutical QC, and gemstone authentication.
Primary benefits: No moving parts, portable Raman microscope, transfer libraries
Unique features: Available in 532-, 785-, and 1064-nm excitation wavelengths
Manufacturer: BaySpec, Inc.
Product name: Nomadic
Raman Microscope
For: Lab analysis
Portable: 820 (W) x 410 (D) x 680 (H) mm3
Measurement mode: Raman microscope
Description: Variety of microscope objectives, XYZ stages
Software: (same features as above)
Suggested applications: (same applications as above)
Primary benefits: No moving parts, three simultaneous excitation wavelengths (532, 785, and 1064 nm), ask about other wl options
Manufacturer: BaySpec, Inc.
Product name: RamSpec-HR-1064
High resolution Raman instrument
For: Lab and process applications
Portable: 432 x 305 x 178 mm3
Measurement mode: Raman
Description: variety of probes available
Special features: On-board swivel screen Windows-based Netbook PC
Software: (same as above)
Suggested applications: (same as above)
Primary benefits: High ~4–5 cm-1 spectral resolution for the range of 200–3200 cm-1
Unique features: Available in 532-, 785-, and 1064-nm excitation wavelengths
Manufacturer: BioTools, Inc.
Product name: u-BioRAMAN
Portable integrated micro-imaging-Raman spectrometer
For: Laboratory analysis
Portable: 14 in. length x 11 in. high, approx. 10 lb.
Measurement mode: Transmission and microscopy
Description: Solid and liquid sampling accessory included; microscopy and visible imaging
Special features: The first portable microscope, easy translation between measurement modes — solids and liquids or visible and Raman. Built-in microscope
Suggested applications: Biopharmaceutical — specially designed for protein structure elucidation and comparability studies; pharmaceutical drug analysis; forensic analysis; polymers; geology; and semiconductor.
Primary benefits: Provides very high sensitivity. Specifically designed for biological samples — includes programs for structure elucidation and database of Raman spectra of proteins in solid and solution states.
Unique features: Attractive features include small size and light weight, ease of use and ability to obtain Raman and visual microscopic images of solids and ordinary Raman of biosolutions in quartz cuvettes with high signal quality and resolution.
Manufacturer: B&W Tek, Inc.
Product name: NanoRam
Available as: Handheld Raman spectrometer
For: Handheld applications
Portable: 9 x 4.125 x 2.25 in.
Measurement mode: Raman scatter
Special accessoryDescription: Sampling Attachments: point and shoot, vial holder, right angle
Special features: Portable, compact, battery powered, 21CFR11 compliant, cGMP compliant.
Suggested applications: Incoming material identification and verification, at-line sampling and final inspection, and counterfeit drug detection
Primary benefits: Rapid validation and deployment within cGMP facilities is made possible by the combination of near-laboratory grade Raman spectral analysis together with validated methods and libraries.
Unique features: TE cooled detector, VBG stabilized laser, API spectral library comes standard, Wi-Fi and USB communications, portable, wireless interface with iPads and other tablet PCs, 2900-cm-1 spectral range
Manufacturer: DeltaNu, a business unit of Intevac Photonics
Product name: PHARMA•ID
Hand-held Raman spectrometer
New this year: Pass/Fail analysis, 21 CFR Part 11 compliant, CAMO Unscrambler-X software package, BlueTooth bar-code scanner
Portable: 5.25 x 2.5 x 1.5 in. (13.5 x 6.5 x 4 cm)
Special features: Smallest handheld Raman available.
Suggested applications: Pharmaceutical identification
Manufacturer: DeltaNu, a business unit of Intevac Photonics
Product name: DeltaNu Advantage Series
Raman spectrometer
For: Laboratory analysis
New this year: improved specifications
Software: NuSpec software, CAMO Unscrambler-X, Grams software
Suggested applications: University teaching labs, research and development
Primary benefits: High performance in a low-cost system
Unique features: Available with 532 nm, 633 nm, 785 nm, and 1064 nm
Manufacturer: Enwave Optronics, Inc.
Product name: EZRaman-H-G4 Handheld Raman analyzer
GasRaman-NOCH2 field-portable multiple gas analyzer
For: Lab, handheld analysis
Portable: 9 x 9 x 4 in.; 5.5 lb
Measurement mode: Reflection
Special features: GasRaman-NOCH2 is a fully integrated, battery-powered, and portable multi-gas analyzer for the measurement of high PPM to percentage range of gases.
Accessory description: Bar-code scanner, tablet (pill) holder, flow through gas sampler
21CFR11 compliant, cGMP compliant
Suggested applications: Pharmaceutical incoming raw material identification, plastic recycling, security/forensics, field multiple-gas analysis
Primary benefits: High sensitivity Raman measurements with handheld packaging
Unique features: Desktop lab instrument sensitivity in handheld format
Manufacturer: Hamamatsu Corporation
Product name: C11714CA Raman mini-spectrometer
Available as: Raman spectrometer
For: Laboratory analysis
Measurement mode: Reflection
Special features: Miniature spectrometer with built-in CCD image sensor and optics, 790–920 nm sensitivity, 0.3-nm spectral resolution, 1024 pixels, compact size (120 x 70 x 60 mm)
Suggested applications: Raman spectroscopy
Primary benefits: High-sensitivity measurements and compact size
Unique features: The C11714CAs built-in CCD has low etaloning characteristics, ensuring optimum detector performance.
Manufacturer: Horiba Scientific – OEM Division
www.horiba.com/MiniCCT+ or www.oemraman.com
Product name: Mini-CCT+ miniature Raman spectrometer
Raman spectrometer
For: Lab, process, handheld applications
New this year: Unmatched 7000:1 dynamic range back-illuminated CCD for high end OEM applications.
Portable: 2.5 × 4 × 1.6 in. (63.5 × 101.6 × 40.6 mm)
Accessory/component: SMA fiber-optic coupling and USB-2 high speed interface
Measurement mode: Raman emission
Special features: Miniaturized for handheld applications
Suggested applications: Homeland security, medical, biotechnology
Primary benefits: High throughput (f/3.1); new tall back-illuminated CCD with high dynamic range.
Unique features: Outperforms current mini-spectrometers based on front-illuminated CCDs, or low-cost back-illuminated CCDs.
Manufacturer: Mustard Tree Instruments
Product name: VerifierR Process System 1000
Raman spectrometer
For: Process analysis
Transportable: Weight is approximately 12 lb
Accessories: Attaches to pipes, tanks, and reactors, tubing or flow cells.
Measurement mode: Raman scattering
Special features: Environmentally rated for IP67 and NEMA 6
Software:21CFR11 compliant, cGMP compliant, may be used in other equipment, compatible with other manufacturers' equipment
Suggested applications: Purity, chemical ID, mixture analysis, concentration analysis of mixtures, reaction completion.
Primary benefits: Rapid method development, Rapid set ups
Unique features: Limits of detection at or below 1%, adaptive lens technology automatically optimizes S/N.
Manufacturer: Real-Time Analyzers
Product name: SERS-Lab 785
Dispersive 785-nm Raman spectrometer with integrated 96-well plate reader
For: Lab applications
Suggested applications: Surface-enhanced Raman spectroscopy (SERS) for trace chemical detection, normal Raman.
Special features: Sol-gel based SERS coatings on the following substrates: 2-mL vials, capillaries, 96-well microplates). The robotic plate reader contains accessories for 2-mL sample vials, capillaries, and active 96-well microplates.
Primary benefits: High performance dispersive 785 nm for high throughput screening. Automated sampling for multiple samples or for mapping of individual samples.
Unique features: Optimized for our proprietary SERS substrates with gold or silver nanoparticles.
Manufacturer: Renishaw plc
Product name: RA800-series OEM benchtop instruments
Raman Spectrometer
For: Lab analysis
New this year: Brand new product, aimed at commercial partners
Measurement mode: Backscattered Raman
Description: Customized for each OEM; enables OEM to offer their customers research grade Raman microscopy performance in a Class 1 laser safe, simple to use system.
Suggested applications: Any requiring rapid Raman analysis, especially imaging. Simplicity and ease of use make the RA800-series ideally suited for routine use in laboratories, QA/QC, and at-line.
Unique features: Innovative technology results in very rapid data collection of high resolution Raman spectra and images. Can be provided in a range of configurations, with different excitation wavelength, spectral coverage, sample handling, and software.
Manufacturer: Rigaku Raman Technologies
Product name: Xantus-2 dual-wavelength handheld Raman analyzer
For: Lab, process, handheld applications
New this year: World's first dual-wavelength handheld Raman analyzer. Designed specifically to overcome the intrinsic fluorescence issues found in many materials
Portable: 138 X 274 X 98 mm (WxDxH) (8.1 lb)
Special features: Portable, battery powered, open spectral library, two analyzers in one box
Suggested applications: In-line pharmaceutical processing, authentication, anti-counterfeiting, explosive and chemical warfare agents, hazardous and chemical spills, RFAW material raw ID, narcotics and illicit street drugs.
Primary benefits: Only company that offers 1064-nm excitation source
Unique features: Two analyzers in one with 1064- and 785-nm excitation sources, open spectral library, no sample prep, cooled detectors for better sensitivity
Manufacturer: Thermo Fisher Scientific
www.thermoscientific.com/trunarc
Product name: Thermo Scientific TruNarc
Product type: Raman Spectrometer
New this year: Thermo Scientific TruNarc analyzer
Portable: 6.4 x 4.1 x 2.0 in. (16.26 x 10.41 x 5.1 cm), weighs just 1.25 lb (570g)
Special features: Nondestructive, noncontact testing preserves evidence; automated data storage and report generation; lightweight, handheld analyzer.
Suggested applications: Narcotics identification for law enforcement, customs, border patrol
Unique features: Library can be updated to include new threats, includes Reachback feature, enabling user to reach a spectroscopist 24/7/365 for advanced questions.
Getting accurate IR spectra on monolayer of molecules
April 18th 2024Creating uniform and repeatable monolayers is incredibly important for both scientific pursuits as well as the manufacturing of products in semiconductor, biotechnology, and. other industries. However, measuring monolayers and functionalized surfaces directly is. difficult, and many rely on a variety of characterization techniques that when used together can provide some degree of confidence. By combining non-contact atomic force microscopy (AFM) and IR spectroscopy, IR PiFM provides sensitive and accurate analysis of sub-monolayer of molecules without the concern of tip-sample cross contamination. Dr. Sung Park, Molecular Vista, joined Spectroscopy to provide insights on how IR PiFM can acquire IR signature of monolayer films due to its unique implementation.
