Application Notes

This technical note describes features and functionality of Agilent MicroLab software (version 5.2 and later) in combination with SCM and SDA for data management and electronic traceability, which enable customers to implement the guidelines of 21 CFR Part 11.

This note highlights OpenLAB ECM Compliance Pack for UV-Vis Benefits such as efficient data storage and retrieval, security, data integrity and traceability, and 21 CFR Part II Comliance.

This note looks at specific components that require validation; the instrument, software, and validated test methods, and describes the features of the Agilent Cary 8454 UV-Visible system that is designed to meet the requirements of both initial and recurrent validation.

This note describes how the design of the Cary 8454 UV-Vis exceeds performance requirements stipulated by global pharmacopeia guidelines including USP and EP/BP. Configured for compliance, with 21 CFR Part 11, the instrument performs multi wavelength analysis, time-based kinetics assays, and routine QA/QC measurements.

This application note demonstrates how Agilent’s Cary 630 FTIR easily meets the specifications of the US, European, Japanese, Chinese, Indian and International Pharmacopoeia. Its combination of compact size, design, intuitive and regulation-compliant software makes the Cary 630 FTIR an ideal instrument for pharmaceutical quality control.

The Agilent Cary 8454 UV-Visible system is ideal for regulatory Pharma QA/QC applications, and can acquire a complete spectrum in less than 1 second. This technical note outlines both applications-based and technical considerations for choosing a diode array UV-Vis

This application note describes a very sensitive classification method, partial least squares–discriminant analysis (PLS-DA), incorporated in Agilent innovative MicroLab software, to classify and qualify materials of interest with greater sensitivity and specificity than possible with simple library search methods.

The ability to easily characterize thin films by variable angle transmission and reflection is very important in both the design/development process and in the final production. This note presents the use of UV-Vis-NIR spectroscopy to characterize film samples in the full spectral region, from UV to NIR.

Photoluminescence (PL) lifetime measurements in NIR are the key parameters in assessing the optical efficiency of devices involving lanthanides, as well as in quality control during their manufacturing.

This application note describes the measurement of food macronutrients by diamond attenuated total reflectance (ATR) mid infrared spectroscopy. Specific examples include the measurement of sugar content of grapes (grape juice) and the measurement of fats in cheese, chocolate and milk.

Miniature X-ray sources reached the development level that is appropriate for their use in the handheld and portable X-Ray diffraction (XRD) instruments. This note describes the application of X-ray sources for the residual stress measurements using XRD.

Spectrochemical analysis is a comparative technique; therefore, unknown samples are best analyzed against reference materials of similar composition.

Raman spectroscopy offers a number of benefits for testing and characterization, with the selection of system components and measurement parameters offering great flexibility.

NMR spectra are chemically specific, enabling the measurements to be sensitive to molecular structure and reaction kinetics. Examples such as acetalisation of acetaldehyde are explained.

PFA cyclonic spray chamber was evaluated for use with a Thermo ElementXR HR-ICP-MS. The signal stability of the cyclonic spray chamber was studied, along with its washout.

Understand how specific design features achieve extreme matrix tolerance and chemical inertness combined with high sensitivity and precision.

Reliability of a low flow glass concentric nebulizer combines with chemical resistance and low elemental background of a PFA concentric nebulizer.

FT-IR microscopy constitutes a very fast and efficient alternative to the well-established staining methods. It allows to analyze biological samples with minimal sample preparation and without the need for any agents for contrast enhancement.

Single use of plastic products contributes to a dramatic trash problem worldwide. Since the near-infrared spectrum of every polymer is unique, spectroscopy can be used to identify and sort a large variety of plastics with high specificity. This application note demonstrates the principle of plastic sorting using near-infrared spectroscopy.

Detecting impurities in any chemical reaction is becoming increasingly important to detect those present at low levels (for example, 0.5%).

IR and Raman spectroscopy are powerful analytical techniques to detect, discriminate and identify material on a molecular level. In particular Raman spectroscopy offers some advantages when applied to art and archaeology as well as earth sciences.

Analysis of trace elements in petrochemical samples is routinely carried out for quality control and process monitoring using protocols set by organizations such as ASTM. However, analysis of these samples is often challenging due to the high matrix and potential for interferences. This executive summary will provide essential information on how to develop robust methods over coming these challenges and ensure excellent results when analyzing trace elements in petrochemicals samples by ICP-OES.

Pharmaceutical material analysis is performed to confirm the purity and genuine composition of active pharmaceutical and additive ingredients. This report describes the integration of Attenuated Total Reflection (ATR) Fourier Transform infrared (FT-IR) spectroscopy with video microscopy observation of pharmaceutical materials.

This application note highlights the importance of Coherent anti-Stokes Raman Spectroscopy (CARS), an important research tool for the identification of chemical species and determination of temperature.

The Milestone UltraWAVE is a bench-top instrument that operates at very high pressures and temperatures, capable of processing large, dissimilar and difficult samples quickly, easily-all without batching. The data shown in this technical note demonstrates that the digestion of samples in the UltraWAVE results in uniformly high analytical data quality, making it the ideal solution for trace metals detection in food.

BaySpec’s PeakFinderTM Raman video probe combines a flexible fiber optic probe with microscope objectives allowing sampling down to several microns. Combined with various benchtop Raman spectrometers, the Raman video probe is a unique micro-Raman system available in 532, 785 or 1064nm excitation and various microscope objectives offering unprecedented flexibility and versatility.

Raman spectroscopy is an important instrument in the arsenal of art conservators and archaeologists. This application note summarizes some recent literature on the selection of portable instruments in this field and also documents some successful work done utilizing background correction to elucidate the composition of some challenging green pigments.

In this technical note we discuss the causes and consequences of stray light, and provide suggestions for mitigating its effects in your experimental setup.

The at-line analysis of gold in impregnated stripping solutions during the electrowinning process is demonstrated. EDXRF is used for analysis of the concentrations of gold in strip solution during the processing of ores, tailings and slags.