Antylia Scientific

Webinar Date/Time: Wed, Nov 20, 2024 2:00 PM EST

The Geno/Grinder is a high-throughput plant and animal tissue homogenizer and cell lyser. It is equipped with an adjustable clamp that accommodates a full range of sample vials from 2 mL to 50 mL centrifuge tubes or up to six deep-well titer plates. It is specifically designed for rapid cell disruption, cell lysis and tissue homogenization through bead beating. This enables fast and efficient extraction of nucleic acids, proteins and other molecules. The Geno/Grinder incorporates a password-protected, touch screen control panel, enabling the user to program run time, rate, cycles and pause time.

Sample preparation is the process where a representative piece of material, chemical or substance is extracted from a larger amount, bulk or batch for subsequent analysis. Representative samples are selected to accurately reflect the larger group and represent the characteristics of the whole material. Ideally representative samples are homogeneous or similar in nature, but when that is not possible, the best attempts must be made to achieve samples which represent the majority of the characteristics of the larger grouping. The preparation of samples is one of the most important steps in analytical methods for many reasons, including the fact that some materials cannot be analyzed in an in-situ condition (such as proteins, DNA and RNA). Some samples have interfering substances and species that can produce faulty results. Sample preparation can include many processes, from reactions or treatment with chemical agents, to filtration, dilution, and extraction.

The Cryo-Blade is an ultra high-capacity cryogenic grinder for comminution and processing capability up to 1 kg. The homogeneity of the sample is very efficient. Only 1 g is needed as a representative test sample from a 1 kg ground batch. The high-throughput capability saves valuable time for your laboratory and meets Food and Drug Administration (FDA) regulations. The Cryo-Blade automatically dispenses liquid nitrogen to allow the sample to reach cryogenic temperatures and then activates a grinding phase to pulverize samples, resulting in repeatable and reproducible sample preparation. No liquid nitrogen handling required. When liquid nitrogen is not desired or available, the unit can be used with dry ice to achieve desired results.

Bead beating is an effective process used to disrupt a wide range of biological samples. It is achieved by rapidly agitating samples with grinding media (balls or beads) in a bead beater. Samples can be processed with or without buffer or solvent at room temperature or cryogenically. The Geno/Grinder® and MiniG® are high-throughput homogenizers that can process samples in deep well plates as well as other formats (up to 50 mL tubes). The homogenizers have a linear motion that focuses the kinetic energy of the grinding media on the sample instead of on the sides of the container. Consequently, even resilient samples such as seeds are most effectively homogenized by these linear motion bead beaters.

From entry-level items for the academia market to specialized instruments for the pharmaceutical, life sciences, chemical analysis, environmental testing, diagnostics and healthcare sectors, Cole-Parmer® offers high quality solutions for years of trouble-free operation.