Advertisement

Applied Photophysics Limited

Articles

New Approach for Optimizing a Monoclonal Antibody Biotherapeutic in Different Formulations

September 01, 2009

A prerequisite for a successful biotherapeutic formulation is one where the protein is stable and correctly folded. The new technique of dynamic multi-mode spectroscopy (DMS) was used to study the stability of a monoclonal antibody biotherapeutic formulated in acetate and lactate buffers. The samples were measured several times over a period of weeks and it became apparent that the antibody behaved differently as it aged in the two formulations, with the lactate formulation imparting greater robustness than the acetate.

Advertisement
Advertisement