Thermo Fisher Scientific

Articles

Learn more about several innovative techniques that can shorten time-to-market, reduce development costs, increase yield, and assure quality and pharmacopoeia compliance throughout the drug development process. 

Advancements in Drug Development and Formulation

Discover the benefits of Raman Spectroscopy

Understand how Raman can materially improve your ability to control your bioprocesses and improve quality

See how accessible and easy Raman for PAT can be; the instrument you use and who you lean on for support makes a difference!

Videos

Portable Raman Spectroscopy for Bioprocess and Reaction Monitoring – It’s Easier Than You Think!

Interferences Explained for ICP-MS

To demonstrate the suitability of ICP-OES for fast, sensitive, and robust analysis of elements in water samples, following the DIN EN ISO 11885:2009 requirements.

Fast Analysis of Water Sample by DIN EN ISO 11885:2009

Therapeutic proteins have been explored for their use in cancer treatment, autoimmune disease, and other difficult-to-treat conditions. But, their stability is critical for patient safety and efficacy. This ebook on FTIR/NIR/Raman in Bio/Pharmaceutical Analysis discusses some common techniques used for evaluated the physical stability and activity of biologics.

FTIR/NIR/Raman in Bio/Pharmaceutical Analysis

http://www.spectroscopyonline.com/spec_w/ICPOES

Interferences are a well-known problem in both inductively coupled plasma–optical emission spectroscopy (ICP-OES) and ICP–mass spectrometry (ICP-MS). They can be subdivided into three main types: chemical, physical, and spectral.

Chemical interferences are caused by differences in the way sample and calibration solution matrices behave in the plasma, resulting in changes in atomization and ionization that are dependent on the matrix composition of the sample. An example of this type of interference is the enhancement effect (which causes falsely high results) observed on both atom and ion signals for elements such as arsenic and selenium, when carbon is present in the samples but not the calibration solutions.

Physical interferences are also caused by matrix differences between samples and calibration solutions. Examples of this type of interference include signal suppression (due to high amounts of easily ionized elements, such as sodium, in the samples), drift and signal variability from sample to sample caused by, for example, changes in nebulization efficiency as a result of viscosity differences between samples. These interferences can cause reported results to be either too high or too low if they are not properly corrected for.

The last, and most challenging, type of interference is spectral interference. For ICP-OES, these are observed as either direct or partial emission wavelength overlaps on the signals of target analytes from other elements or molecular species in the sample. For ICP-MS, spectral interferences from other elements in the sample appear as either direct (from singly charged ions) or half-mass (from doubly charged ions) overlaps on the target ion isotope signals. With ICP-OES, spectral interferences, like physical interferences, can cause falsely high or falsely low results. With ICP-MS, the overlaps caused by interfering signals generate false positive signals, but if incorrect mathematical corrections are applied to the data, falsely low results can also be reported.

In this two-part webinar series, the sources of interferences in ICP-OES and ICP-MS and how to identify them will be described. Software approaches for correcting interfered results which each technique will be presented and the latest instrumental developments for minimizing interference problems will also be discussed.

Understand what types of interferences exist in ICP-OES and ICP-MS and how they affect your results.

Learn strategies for identifying and managing these interferences.

Find out how innovations in hardware help reduce interferences, improve accuracy, and remove the need to re-run samples.

Discover how intelligent software tools enable easier, interference-free method development.

Analysts wishing to enhance their elemental analysis knowledge

Instrument operators who encounter problems with inaccurate data and want to know how improve their results.

Laboratory managers who need to lower detection limits, reduce sample re-runs, and accelerate sample turnaround times

Webcasts

Wednesday, September 22, 2021 at 11am EDT| 8am PDT| 4pm BST| 5pm CEST

Do you have problems with false positive or negative results with your ICP-OES or ICP-MS analyses? Are you wondering where the interferences causing these errors are coming from? If so, join this webinar to learn how to identify interferences, develop strategies to manage them and discover new hardware solutions that enable unprecedented levels of accuracy for your elemental analysis.

Interferences Explained, ICP-OES Part 2

Wednesday, September 15, 2021 at 11am EDT| 8am PDT| 4pm BST| 5pm CEST

Do you have problems with false positive or negative results with your ICP-OES or ICP-MS analyses? Are you wondering where the interferences causing these errors are coming from? If so, join this webinar to learn how to identify interferences, develop strategies to manage them and discover new hardware solutions that enable unprecedented levels of accuracy for your elemental analysis.

Interferences Explained, ICP-OES Part 1

Granulation is a common process in pharmaceutical manufacturing to convert powder mixtures into agglomerated particles and is usually performed prior to tableting. Twin-screw granulation (TSG) has gained increased interest from the pharmaceutical industry for its potential within the development of oral dosage forms. It is a very flexible technology that can help to process a wide range of processed in a continuous manner. Twin-screw extruders offer excellent process control, can be equipped with high Process Analytical Tools (PAT), and processes can be optimized by using a Quality by Design (QbD) approach. All that leading to a high and stable product quality.

Within this webcast we review the basic concept of TSG, discuss the influence of process parameters on final product quality and give an insight into recent advances in TSG continuous manufacturing.

Review the principles of TSG and granulation mechanisms

Understand continuous TSG systems, including state of the art systems

Understand quality-by-design approaches and process analytical technology for TSG

Formulation scientists and engineers in the pharmaceutical industry Academics who want to learn more about the possibilities to use TSG for wet and melt granulation in R&D and manufacturing.

Professor in Pharmaceutical Technology and Process Engineering;
Director of Centre for Innovation in Process Engineering and Research

Friday, August 13, 2021 at 11am EDT| 8am PDT| 4pm BST|5pm CEST


Advances in Twin-Screw Granulation Technologies

Non-Traditional Stable Gas Isotope Approaches: Clumped Isotopes and Fragment Ion Analysis

http://www.spectroscopyonline.com/spec_w/trace_elements

Analysis of samples by ICP-OES for trace elements has the potential to be complex, because both physical and spectral interferences can call into the question any results that are produced. A good approach to overcome these issues is to use a tried and tested method, one such being the US EPA Method 6010D (SW-846), which focuses on the analysis of solid wastes, soils, sediments, sludges, ground and surface waters, etc. As well as being used for its intended purpose to support the analysis of environmental samples, this method is also the ideal starting point for a range of different sample analyses. This webinar will explore this method further, including key steps in validation and adaptation to different sample matrix.

Discover the features of US EPA Method 6010D (SW-846) that make it an ideal starting point for methods development

Find out how to apply key validation steps to ensure freedom from interferences

Understand how advanced ICP-OES instruments and software further aid method development and validation


Regional Marketing Manager
Trace Elemental Analysis (AA, ICP-OES, and ICP-MS), North America

Sabrina Antonio has a degree in Chemical Engineering and a diverse professional background ranging from working in the energy industry as a Senior Chemical Engineer at Consolidated Edison of New York and Construction Project Manager for the New York Power Authority, to serving as a Chemist and Lead Inorganic Data Auditor for the US EPA Contract Laboratory Program, to work as a Product Specialist and Application Engineer for several engineering and manufacturing firms. She joined Thermo Fisher Scientific in 2015 as a Sales Specialist in the Center of Excellence and in 2018, became the Regional Marketing Manager for Trace Elemental Analysis in North America.


Product Marketing Specialist
Trace Elemental Analysis

In 2006 Matthew Cassap joined Thermo Fisher Scientific as an applications specialist. In this role he become an expert in trace element analysis applications across a broad range of industry segments using a range of liquid and solid sampling accessories and hyphenated techniques. In 2012 Matthew assumed responsibility for the Thermo Scientific ICP-OES product line and is based at the manufacturing facility in Cambridge, UK. From 2014 to 2017 Matthew was based at the Thermo Scientific center of excellence in Bremen, Germany, as Product Manager for AA and ICP-OES. In 2018 Matthew relocated back to the UK and is now the TEA Product Marketing Specialist

Tuesday, June 29, 2021 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST