Thermo Fisher Scientific

Articles by Thermo Fisher Scientific

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Special Issues

High resolution mass spectrometry with nano-LC is used for protein identification and quantification in both top-down and bottom-up proteome analysis. Reliable instrumentation in combination with ultrapure mobile phases is essential for data integrity. Premixed 80% acetonitrile with 0.1% formic acid (LS122-500) and water with 0.1% formic acid (LS118-500) were designed to produce a consistent chromatographic performance using this instrument system. In this study, these mobile phases were used extensively to evaluate several factors which can affect separation of protein digests such as peak retention, peak repeatability, and sample carryover. Our results demonstrated excellent chromatographic performance using Thermo Scientific EASY-nLC 1200 LC system and Thermo Scientific LTQLX ™ ion trap mass spectrometer with the specialized premixed mobile phases.

Spectroscopy

In this executive summary learn how to use isotope-ratio MS to determine the isotopic profile or “signature” of a material, and to hear about how this technique can be used in forensic investigations to measure a variety of materials, including drugs, explosives, currency, food, beverages, animal tissues like ivory, and human remains.

Spectroscopy

The development of an analytical method for ICP-OES is often seen as challenging, due to the large number of sample introduction components on the market, the possible parameters for sample introduction and plasma and measurement conditions, and finally, questions about how to interpret the data. This executive summary will demonstrate how to achieve your goal when developing a method: determining a set of parameters that ensure an accurate, precise and repeatable result on a daily basis.

Spectroscopy

Analysis of trace elements in petrochemical samples is routinely carried out for quality control and process monitoring using protocols set by organizations such as ASTM. However, analysis of these samples is often challenging due to the high matrix and potential for interferences. This executive summary will provide essential information on how to develop robust methods over coming these challenges and ensure excellent results when analyzing trace elements in petrochemicals samples by ICP-OES.

Spectroscopy

To learn more about Method development for ICP-OES, Spectroscopy Magazine talked with Matthew Cassap, Product Manager ICP-OES, AA, and Trace Elemental Analysis at Thermo Fisher Scientific.