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Photonics Applications in Environmental SciencesSeveral spectroscopic measurement techniques are proving to be very effective and versatile for environmental applications.
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Criteria for High-Quality Raman MicroscopyFive key qualitative factors–speed, sensitivity, resolution, modularity and upgradeability, and combinability–contribute to the quality of confocal Raman imaging microscopes. Using application examples, this article introduces modern Raman imaging and correlative imaging techniques, and presents state-of-the-art practice examples from polymer research, pharmaceutics, low-dimensional materials research, and life sciences.
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The miniDOAS: Low Cost, High Performance Contactless Ammonia MeasurementsKnowledge of atmospheric ammonia concentrations is important, but ammonia is difficult to measure. We report here on the development of a low-cost ammonia measuring differential optical absorption spectroscopy (DOAS) instrument, based on a small sized and low priced spectrograph.
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Real-Time Water Monitoring With New UV SpectrometerThe C16767MA miniaturized ultraviolet (UV) spectrometer, developed by Hamamatsu, offers a groundbreaking solution for real-time, on-site water quality monitoring, replacing traditional, labor-intensive methods.
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Deep Learning Advances Gas Quantification Analysis in Near-Infrared Dual-Comb SpectroscopyResearchers from Tsinghua University and Beihang University in Beijing have developed a deep-learning-based data processing framework that significantly improves the accuracy of dual-comb absorption spectroscopy (DCAS) in gas quantification analysis. By using a U-net model for etalon removal and a modified U-net combined with traditional methods for baseline extraction, their framework achieves high-fidelity absorbance spectra, even in challenging conditions with complex baselines and etalon effects.
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Analysis of a Mixture Solution Using Silver Nanoparticles Based on Surface-Enhanced Raman Spectroscopy (SERS)SERS can be used for the detection and monitoring of drugs as pure compounds and mixtures. A demonstration of a sample preparation method used to detect components with weak substrate adsorption in the spectrum of a mixed solution is shown.
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Analysis of a Mixture Solution Using Silver Nanoparticles Based on Surface-Enhanced Raman Spectroscopy (SERS)SERS can be used for the detection and monitoring of drugs as pure compounds and mixtures. A demonstration of a sample preparation method used to detect components with weak substrate adsorption in the spectrum of a mixed solution is shown.
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Quantitative Detection of Phenobarbital in an Injectable Solution Based on Surface-Enhanced Raman SpectroscopyThis SERS method is rapid, accurate, nondestructive, and easy
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Analysis of a Mixture Solution Using Silver Nanoparticles Based on Surface-Enhanced Raman Spectroscopy (SERS)SERS can be used for the detection and monitoring of drugs as pure compounds and mixtures. A demonstration of a sample preparation method used to detect components with weak substrate adsorption in the spectrum of a mixed solution is shown.
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Quantitative Detection of Phenobarbital in an Injectable Solution Based on Surface-Enhanced Raman SpectroscopyThis SERS method is rapid, accurate, nondestructive, and easy
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Quantitative Detection of Phenobarbital in an Injectable Solution Based on Surface-Enhanced Raman SpectroscopyThis SERS method is rapid, accurate, nondestructive, and easy
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Epitope Mapping of an Interleukin Receptor for Three Therapeutic Antibodies by Hydrogen-Deuterium Exchange Mass SpectrometryAmong all the analytical techniques available for epitope mapping studies, hydrogen–deuterium exchange mass spectrometry (HDX-MS) is usually the fastest and easiest to carry out. We present here the epitope mapping of three distinct monoclonal antibody (mAb) candidates targeting the same antigen, an interleukin receptor. The goal is to establish the binding mode of these mAbs, and explain possible differences observed for in vitro binding and in vivo function.
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Epitope Mapping of an Interleukin Receptor for Three Therapeutic Antibodies by Hydrogen-Deuterium Exchange Mass SpectrometryAmong all the analytical techniques available for epitope mapping studies, hydrogen–deuterium exchange mass spectrometry (HDX-MS) is usually the fastest and easiest to carry out. We present here the epitope mapping of three distinct monoclonal antibody (mAb) candidates targeting the same antigen, an interleukin receptor. The goal is to establish the binding mode of these mAbs, and explain possible differences observed for in vitro binding and in vivo function.
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Epitope Mapping of an Interleukin Receptor for Three Therapeutic Antibodies by Hydrogen-Deuterium Exchange Mass SpectrometryAmong all the analytical techniques available for epitope mapping studies, hydrogen–deuterium exchange mass spectrometry (HDX-MS) is usually the fastest and easiest to carry out. We present here the epitope mapping of three distinct monoclonal antibody (mAb) candidates targeting the same antigen, an interleukin receptor. The goal is to establish the binding mode of these mAbs, and explain possible differences observed for in vitro binding and in vivo function.
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Enhancing the Sensitivity of Atmospheric Pressure Ionization Mass Spectrometry Using Flow Modulated Gas ChromatographyThe past decade has witnessed resurgent interest in coupling GC to atmospheric-pressure chemical ionization (APCI), which is suitable for the high column flows required for using flow modulation. This study assesses the use of GP-APCI with flow modulation for sensitive detection of selected trace organics.
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Recent Advances in Hyphenated Chromatography and Mass Spectrometry Techniques and Their Impact on Late-Stage Pharmaceutical DevelopmentIn late-stage pharmaceutical development a new generation of high-resolution mass spectrometers and ion mobility mass spectrometers operate as orthogonal separation techniques and have greatly increased the ability to resolve impurities and increase the level of analytical information gained from a single analysis.
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Recent Advances in Hyphenated Chromatography and Mass Spectrometry Techniques and Their Impact on Late-Stage Pharmaceutical DevelopmentIn late-stage pharmaceutical development a new generation of high-resolution mass spectrometers and ion mobility mass spectrometers operate as orthogonal separation techniques and have greatly increased the ability to resolve impurities and increase the level of analytical information gained from a single analysis.
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Effective Abatement of High Lead Level Contamination in a Forensic Firing Range via Inductively Coupled Plasma–Mass SpectrometryTest firing a firearm is frequently used for forensic firearms and bullet identification. Airborne lead-containing particles are emitted when a firearm is tested, leading to lead building up on surfaces, exposing employees to potential lead-related health risks. Prior to cleaning, lead surface concentrations in the firing range at the National Forensic Laboratory Services in Ottawa were found to be higher than the Environmental Abatement Council of Ontario (EACO) post-abatement limit, with the highest level 56 times the limit. Inductively coupled plasma–mass spectrometry (ICP-MS), along with internal standardization, revealed that wiping surfaces with either a commercial decontamination product containing ethylene glycol butyl ether (EGBE) or alcohol cleaning pads satisfied the EACO standard by removing over 90% of lead from test surfaces whereas an external cleaning company only removed 36% of lead from the same surfaces. Fortunately, lead cross-contamination was minimal outside the firearms section and well below the residential EACO limit.
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Characterization of Glitter Cosmetic Particles Using FT-IR SpectroscopyGlitter particles from cosmetics may transfer during personal assaults, and thus glitter may be useful as a forensic tool. In this study, glitter samples were analyzed using ATR–FT-IR in an attempt to develop a characterization scheme to aid in the identification of these particles.
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GC×GC–MS for Forensic AnalysisForensic scientists often encounter highly complex analytical problems related to crime scenes that would benefit from the capabilities of GC×GC–MS. However, this technique has not been fully explored to help benefit forensic laboratories.
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A Spectroscopic Revolution in the Agricultural WorldIn celebration of Spectroscopy’s 35th Anniversary, leading experts discuss important issues and challenges in analytical spectroscopy.
