Zoran Sosic


Aggregate and Fragment Analysis in Therapeutic Monoclonal Antibodies Using On-Line Size-Exclusion Chromatography with Native Mass Spectrometry

Size-exclusion chromatography (SEC), with the use of ammonium acetate buffer, can be coupled on-line to electrospray ionization MS for the characterization of size variants of therapeutic monoclonal antibodies (mAbs). A quadrupole time-of-flight (QTOF) MS system was employed, and the MS method was optimized to achieve favorable sensitivity for high-mass detection, while maintaining the structural integrity of the aggregates (or high molecular weight species) and fragments (or low molecular weight species).

Hongfei Xie


Inversion of Low-Grade Copper Mining Areas Based on Spectral Information and Remote Sensing Data Using Vis-NIR

Depletion of modern mineral resources due to continuous exploitation and utilization makes it economically necessary to quickly identify the locate sources of low-grade ore. Here, we propose a vis-NIR remote sensing method to determine copper content in mining areas as well as to measure the environmental impact of surface mining methods.

Yu Huang


Enhanced Raman and Mid-Infrared Spectroscopic Discrimination of Geographical Origin of Rice by Data Mining and Data Fusion

The application of data mining combined with data fusion of Raman and mid- infrared spectra was studied to improve discrimination ability for modeling the geographical origins of rice.



Ultrapure Water to Assess Toxic Elements

This study demonstrates the suitability of freshly prepared ultrapure water for ICP-MS trace element analyses in environmental laboratories

Gene Hall


A Different Kind of Art Analysis

Raman and XRF spectroscopy were used to examine paint in artwork, revealing the potential of both techniques to verify the authenticity of famous works of art.

Katie Comstock


Extractable and Leachable Testing for Pharmaceutical Packaging, Finished Pharmaceutical Products, and Medical Devices: An Analytical Perspective

Extractable and leachable (E&L) testing for finished pharmaceutical products, bioprocess manufacturing systems, and medical devices is currently a subject of intense interest. The majority of the challenges encountered in analytical workflows are related to the highly complex matrices and relatively low analyte evaluation thresholds seen in E&L studies. This paper provide options for executing E&L testing to supporting regulatory submissions. There are multiple compliant routes possible, and the presented workflows and analytical solutions are only one of multiple successful approaches.

Yongbo Yu


Specific Recognition Technology of Infrared Absorption Spectra Based on Continuous Wavelet Decomposition

IR absorption spectroscopy technology can solve the problem of line aliasing in gas detection. Here, continuous wavelet transform was used in time-frequency analysis to improve spectral component identification and quantitative detection of gases.

Xun Zhang


Terahertz Spectral Investigation of L-Cysteine Hydrochloride and its Monohydrate

This new terahertz method provides a theoretical reference for studying the relationship between biomolecules and water.

Yugal Khajuria


EDX and LIBS Studies on Gallstones Using Partial Least Squares Discriminant Analysis (PLS-DA)

Understanding gallstone formation requires examining their elemental composition. Here, EDS and LIBS were used with PLS-DA to quantify elements found in human gallstones.

Chunhai Li


Hyperspectral Imaging Combined with Convolutional Neural Network for Rapid and Accurate Evaluation of Tilapia Fillet Freshness

The purpose of this work is to achieve rapid and nondestructive determination of tilapia fillets storage time associated with its freshness. Here, we investigated the potential of hyperspectral imaging (HSI) combined with a convolutional neural network (CNN) in the visible and near-infrared region (vis-NIR or VNIR, 397−1003 nm) and the shortwave near-infrared region (SWNIR or SWIR, 935−1720 nm) for determining tilapia fillets freshness.

Sarah Theiner


Single-Cell Analysis by ICP-MS—Current Status and Future Trends

Single-cell analysis is important in biology and medicine, because it takes into account cell heterogeneity and cellular dynamics, which are governed by cellular crosstalk and the vicinity of cells. Thus, it is of utmost importance to obtain not only information about the heterogeneity of a cell population, but also about their spatial arrangement.

William Killian, Sr.


A MATLAB Application for Calculation of Cell Pathlength in Absorption Transmission Infrared Spectroscopy

Reliable quantitative FT-IR measurements require that the pathlength be known to within 1%. Pathlength estimations based on nominal spacer thickness are not reliable and require that the actual pathlength be measured for accurate data. We demonstrate how.

Thomas Perilli


Raman Spectroscopy in Analyzing Fats and Oils in Foods

Several types of Raman spectroscopy, including Fourier transform (FT)–Raman and dispersive Raman, are well suited to examine and understand the fat compositional heterogeneity in solid foods, identify polymorph or crystallinity, and measure fatty acid saturation.

John Cooper


A Dual Nanostructured Approach to SERS Substrates Amenable to Large-Scale Production

SERS can amplify Raman signals, but to make the technique practical for industrial use, large quantities of substrate are needed. The approach described here could enable cost-effective, reproducible manufacturing of SERS substrates at large scale.

Suqin Wang


Exploring the Potential of the Yb(III) (HE)4 Complex for Oncotherapy Using UV-vis Spectroscopy

Evaluation of the UV-vis spectra of the reaction product of ytterbium (III) with hematoxylin (HE) indicates the formation of a rare earth complex that further reacts with marine mammal DNA, indicating the potential that this complex may have anti-tumor properties.

Macy Harris


Analysis of Elements in Snack Foods: A Closer Look at Pepperoni, Rice Noodles, Frozen Dinners, and Pizza

Software tools for ICP-MS and ICP-OES can help analysts to simplify method setup and reduce the potential for errors.

Huizhen Cui


Detection of the Early Fungal Infection of Citrus by Fourier Transform Near-Infrared Spectra

We examine the feasibility of FT-NIR for the detection of early fungal infections in citrus.

Qing Wang


A Raman Spectral Area Scanning Method to Identify the Sequences of Crossed Writings and Seal Stamps

Determining the printing sequences of crossed writings and seal stamps is often difficult because the most common methods used are expensive, time-consuming, and cumbersome. A new method using Raman spectral area scanning offers a better alternative while conducting pigment analysis and determining intersection sequences of writings and seal stamps. We explain why.

Andrew Fornadel


Analyzing Water Samples Using EPA Method 200.8 to Support the Lead and Copper Rule Revisions

EPA Method 200.8 and the Lead and Copper Rule Revisions don’t allow use of modern ICP-MS technology with a collision cell. Instead, correction equations can be used to compensate for polyatomic interferences.

Dandan Gao


An X-ray Fluorescence (XRF) Analysis of a Molecular Layer Deposition (MLD) Method Used in Producing Cement from Phosphogypsum

Phosphogypsum can be used as an intermediary material to produce cement clinker. To monitor the quality of phosphogypsum cement, a novel molecular layer deposition X-ray fluorescence (XRF) analysis method using a glass frit was developed.

Weijuan Zhao


Technological Analysis of Glazed Tiles Unearthed from Bao’ensi in Nanjing

UV-Vis-NIR can be used to understand how ancient buildings were constructed. Here, a UV-Vis-NIR and EDXRF spectrophotometer were used to analyze glazed tiles that comprised a historical site built in Ancient China.

Miguel A. Alba


Fiberoptic Formaldehyde Field Sensors for Industrial Environments: Capitalizing on Evanescent-Wave Spectroscopy

An inexpensive fiberoptic-based formaldehyde field sensor is described for monitoring low-levels of formaldehyde, a widespread indoor air pollutant, based on the principle of evanescent wave absorption of light. Sensor prototypes following that principle are being tested in two plywood board production plants.

Junsheng Li


Interacting Characteristics of Chrysene with Free DNA in vitro

DNA effectively removes chrysene from contaminated water through intercalation, as confirmed by various analytical methods, offering a potential novel approach for chrysene elimination in water pollution.

Giorgio S. Senesi


Handheld Laser-Induced Breakdown Spectroscopy (hLIBS): A Valuable Tool for Terrestrial and Extraterrestrial Recognition of Meteorites in the Field

The fast data acquisition and minimal sample preparation of handheld LIBS devices make them very useful for geochemical mapping, resource prospecting, sample selection, and hazard identification.

Wangfeng He


Review and Prospect: Applications of Exponential Signals with Machine Learning in Nuclear Magnetic Resonance

A review of exponential signal models with machine learning in nuclear magnetic resonance (NMR) spectroscopy is discussed here.

Eric D. Winegar


Real-World Application of Open-Path UV-DOAS, TDL, and FT-IR Spectroscopy for Air Quality Monitoring at Industrial Facilities

The implementation of 120 open-path spectroscopy analyzers at oil refineries has taught us lessons about compound identification, target species detectability, interferences, and data management, which can help spectroscopists generate more accurate data when monitoring air quality.