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Comprehensive Analysis of Persistent Organic Pollutants in Complex Matrices 48 Using GC with High-Performance TOF-MSThe combination of GC with time-of-flight (TOF)-MS proves to be a successful approach for the challenging analysis of persistent organic pollutants in complex matrices such as sediment and fish samples.
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Medical Imaging with Filters and Quantum DotsThe onset of nanotechnology and targeted therapy methods for a number of pathologies has made it increasingly more difficult to image effectively in the medical field. With that being said, the inception of quantum dots and the improvements to optical filters has made this once daunting task a common practice.
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High-Definition Screening for Boar Taint in Fatback Samples Using GC–MSHigh-definition screening by gas chromatography–mass spectrometry (GC–MS) is shown to be a viable option for the reliable identification of odorous compounds in pork.
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Why Use Signal-To-Noise As a Measure of MS Performance When It Is Often Meaningless?Signal-to-noise of a chromatographic peak from a single measurement has been used determine the performance of two different MS systems, but this parameter can no longer be universally applied and often fails to provide meaningful estimates of the instrument detection limits (IDL).
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Rapid and Accurate LC–MS-MS Analysis of Nicotine and Related Compounds in Urine Using Raptor Biphenyl LC Columns and MS-Friendly Mobile PhasesA rapid, accurate, and reproducible method was developed for high-throughput testing of nicotine, cotinine, trans-3’-hydroxycotinine, nornicotine, norcotinine, and anabasine in urine. Data show that a fast and highly efficient analysis of these basic compounds can be achieved with the Raptor Biphenyl column using standard reversed-phase LC–MS mobile phases that are compatible with a variety of LC–MS instrumentation.
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Discrimination of Lipids in Heart Tissue using DESI HRMS MSIMass Spectrometric Imaging (MSI) using DESI provides molecular imaging without the interference of the matrix required for MALDI and offers the advantage of preserving sample for further analysis. DESI coupled to High Resolution Accurate Mass (HRAM), is shown here to elucidate spatial distribution of lipids, protein, and metabolites in tissue sections and can provide confident and discriminate biomarker determinations.
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Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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Metabolomics Workflows: Combining Untargeted Discovery-Based and Targeted Confirmation Approaches for Mining Metabolomics DataThe metabolomics workflow described here combines untargeted (discovery) quadrupole time-of-flight (Q-TOF) liquid chromatography–mass spectrometry (LC–MS), targeted (confirmation) triple-quadrupole LC–MS-MS, and sophisticated data mining as an effective means to elucidate metabolite changes.
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How to Design a Miniature Raman SpectrometerIn this article, we describe the key factors that influence the overall size of a spectrometer, such as the diffraction grating groove density and detector size. Furthermore, we demonstrate compact Raman spectrometer designs as small as 30 mm × 30 mm in footprint by using highly dispersive gratings and uncooled detectors.
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Advancements in Low Cost Miniature NIR Spectrometers Enable New Applications in Sample Identification and Quality ControlNear-infrared spectroscopy (NIR) is a powerful technique for rapid and non-destructive material analysis. Scientific breakthroughs over the past several decades have made NIR one of the most powerful tools for research, especially in industries such as food and drug, chemical, oil and gas, and plastics. This technique has mainly been limited to non-portable applications due to instrument size, fragility, and cost. Additionally, Database Search Software or Multivariate Prediction Software must also be employed to extract results; however, user-friendly and cost effective solutions have not been widely available.
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Imaging Mass Spectrometry: Current Performance and Upcoming ChallengesA critical look into the future of imaging mass spectrometry is made by addressing some of the fundamental and technical challenges that still need to be overcome.
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25-Hydroxyvitamin D2/D3 Analysis in Human Plasma Using LC–MSIncreases in vitamin D testing frequency have required more rapid and cost-effective solutions for determining vitamin D levels in plasma. This LC–MS method was adapted for use with core-shell columns to achieve run times of less than 4 min.
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Creating a High-Throughput LC–MS-MS System Using Common ComponentsHow to create a liquid chromatography–tandem mass spectrometry (LC–MS-MS) system using mass spectrometers, a high performance liquid chromatography (HPLC) binary pump system, and an autosampler
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stainless and low alloy steel analysis using handheld LIBSAnalysis of stainless steels and nickel alloys with handheld LIBS has proven challenging because Molybdenum – a key alloy element in the 0.5-3% level – is refractory and requires a much hotter plasma than many miniature, commercially available lasers can provide. A new proprietary laser design was utilized in a handheld LIBS analyzer and is shown to provide much better quantitative analysis of Mo down to 0.15% concentration.
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Raman Spectroscopic Evaluation of BonesRaman spectroscopy provides data on bone mineral crystallinity, carbonate to phosphate ratio and extent of collagen cross-linking, all compositional information that is intimately related to biomechanical characteristics of this unique material. Key words for lead email subject line: Raman spectroscopy on bones
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Probing Aqueous Surfaces by TOF-SIMSA breakthrough using a microfluidic interface to conduct sensitive time-of-flight secondary ion mass spectrometry (TOF-SIMS) analysis and study liquid surfaces in situ under vacuum conditions is described here.
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Analyzing Recycled Polyethylene Resin for Polypropylene Contamination Using FT-IRThe use of post-consumer recycled, high-density polyethylene (HDPE) has been steadily growing. Infrared technique is commonly used to identity polypropylene (PP) with is a common contaminant in post-consumer HDPE resin.
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Analyzing Recycled Polyethylene Resin for Polypropylene Contamination Using FT-IRThe use of post-consumer recycled, high-density polyethylene (HDPE) has been steadily growing. Infrared technique is commonly used to identity polypropylene (PP) with is a common contaminant in post-consumer HDPE resin.
Latest:
Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
Latest:
Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
Latest:
Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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XRF in Agronomy Applications—Analysis of Plant Tissues and FertilizersNew excitation developments and advanced detector technology enable the use of EDXRF for multielement analysis of plant material and fertilizers, with improved detection limits and reduced measurement time. These features are combined with easy sample preparation and low cost of investment.
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CMOS Technology for Scientific ImagingStarting in the 1980s and continuing today, there have been large improvements in charge-coupled devices (CCDs), driven to a large extent by the needs of both the military and the scientific community consisting of astronomers, chemists, and biologists. This resulted in technologies such as back thinning to increase UV and near-infrared (NIR) sensitivity, deep depletion to increase NIR sensitivity, as well as the direct detection of X-rays.
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The Big Review VI: Carbonyl CompoundsCarbonyl containing functional groups are strong infrared absorbers and a number of them are easy to identify by infrared spectroscopy. Here, we will review the spectra of ketone and carboxylic acids.
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Elemental Analysis of Goji Berries Using Axially and Radially Viewed Inductively Coupled Plasma–Optical Emission SpectrometryA method for the multielemental determination of metals and nonmetals in goji berries (Lycium barbarum L.) by axially and radially viewed inductively coupled plasma-optical emission spectrometry (ICP-OES) is presented.
