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A Sensitive, Specific, Accurate, and Fast LC–MS-MS Method for Measurement of 42 Ethyl Glucuronide and Ethyl Sulfate in Human UrineA method is illustrated for the simultaneous analysis of ethyl glucuronide and ethyl sulfate in human urine samples.
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Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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Matrix-Assisted Laser Desorption-Ionization Imaging Mass Spectrometry for Direct Tissue AnalysisA summary of the most recent advances in sample preparation, instrumentation, and data-processing techniques for MALDI-IMS
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Probing Aqueous Surfaces by TOF-SIMSA breakthrough using a microfluidic interface to conduct sensitive time-of-flight secondary ion mass spectrometry (TOF-SIMS) analysis and study liquid surfaces in situ under vacuum conditions is described here.
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The pH Dependence of the SERS Spectra of Methyl Yellow in Silver ColloidSurface plasmon resonance, charge-transfer resonance, and their combination determine the enhancement of surface-enhanced Raman scattering signals, and the varying intensities of the signal at different pH levels may result from the change in contributions of the combined system.
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Determination of Sodium Lauryl Sulfate and Sodium Laureth Sulfate in Commercial Body Care ProductsA method for quantifying the percent sulfate associated with sodium lauryl sulfate (also referred to as sodium dodecyl sulfate) and sodium laureth sulfate (also referred to as sodium lauryl ether sulfate) found in commonly used commercial body care products using FT-IR attenuated total reflectance (ATR) spectroscopy is outlined.
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Quantifying Proteins by Mass SpectrometryThe quantification of proteins in a complex biological sample is an important and challenging task. Mass spectrometry (MS) is increasingly used for this purpose, not only to give a global survey of the components and their amounts, but also to precisely and accurately quantify specific target proteins.
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Quantitation of Albumin and Creatinine in Urine by MALDI-TOF Mass SpectrometryChronic kidney disease or kidney complication resulting from another systematic disorder can impact the organ’s blood filtering capability resulting in the passage of blood-born proteins through the kidneys and into urine. Clinical analyses for blood proteins in urine are performed to assess proper kidney function or to monitor a diagnosed disorder. Serum albumin is a common target in these clinical assays and detection of elevated SA levels in urine is termed Albuminuria. Because of normal variability in urine content and volume multiple measurements are often made in comparison to creatitine levels within the same urine sample and reported as a ratio (ACR). Demonstrated here is a novel means for quantifying albumin and creatinine directly from the same urine sample using MALDI-TOF mass spectrometry. Standard addition of albumin and deuterated creatinine (d3) into control urine produced a linear and quantitative response (R2 = 0.99 and 0.98) and is used to quantify both analytes across their clinically relevant ranges. This MS-based method represents a simple, fast, attractive alternative to currently clinical methods.
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Determination of Cannabinoid Content and Pesticide Residues in Cannabis Edibles and BeveragesQuEChERS is introduced to the discipline of forensic testing as a viable method for the extraction of pesticides and cannabinoids in various complex sample matrices.
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Lineshapes in IR and Raman Spectroscopy: A PrimerInfrared and Raman bands are typically described in terms of peak location and peak height. The shape of the peak-its form, width, and asymmetry-is less well understood. Bandshapes largely depend upon interactions between vibrating molecules and their environment. An understanding of this relationship may enhance spectral interpretation and can explain unexpected behaviors, in both qualitative and quantitative analyses. This paper presents basic concepts that influence line shapes and shows the complex lineshape changes in an apparently simple system of acetone and water.
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Atmospheric Applications IFS 125HRBruker's IFS 125HR spectrometer is designed as an ultra-high resolution FT-IR spectrometer which provides outstanding performance for R&D laboratory application.
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Chemical Analysis of Microscopic Fluorescent Materials by Dispersive 1064 Raman SystemRaman measurement on microscopic inclusions in fluorescent materials requires the ability to measure in small volumes, excellent throughput, and long wavelength excitation such as 1064 nm for fluorescence reduction.
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Gas Analysis with the Nicolet iS50 FT-IR SpectrometerCombining a high precision FT-IR spectrometer with a long pathlength gas cell provides a powerful tool for analyzing trace levels of contaminants in air and other gas mixtures (Figure 1). Two important applications of this are ensuring air quality and the purity of breathing oxygen and compressed air.
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Analyzing Absorption of Wood Preservatives Using Micro X-ray FluorescenceTo optimize the mapping collection parameters, it is important to factor the size of the mapping area, the beam diameter, and the desired beam spacing. For this sample, the area being mapped is shown in red outline in Figure 2, approximately 50.4 x 3.5 mm.
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Simultaneous Determination of Methylxanthines and Cotinine in Human Plasma by Solid-Phase Extraction Followed by LC–MS-MSA multiresidue method has been developed and validated for the analysis of methylxanthines (caffeine and its metabolites) and cotinine in human plasma.
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Simultaneous Single Reaction Chamber Microwave Digestion of Mixed-Consumer ProductsMilestone's UltraWAVE microwave digestion system with single reaction chamber (SRC) technology, enables the simultaneous digestion of up of to 22 different sample types and chemistries at temperatures and pressures as high as 300 ?C and 199 bar.
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Novel Methods Using Mass Spectrometry for Food Safety—From Contamination to NutritionIn the human food supply, public confidence is affected by contaminants and misreporting of nutritional information. This article highlights three events that required development of new mass spectrometry methods, including the detection of pesticides (such as fipronil and glyphosate), and the detection and quantification of fat-soluble vitamins.
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GC–MS Analysis of an Herbal Medicinal Remedy to Identify Potential Toxic CompoundsIn most countries, herbal medicinal products (HMPs) are introduced into the market without proper scientific evaluation or enforced safety and toxicological studies.
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Monitoring the Thermal Treatment of a Heterogeneous Catalyst Using DRIFTSThe thermal treatment of a grafted Sn-SiO2 catalyst was monitored in situ using diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS).
Latest:
Quantifying Proteins by Mass SpectrometryThe quantification of proteins in a complex biological sample is an important and challenging task. Mass spectrometry (MS) is increasingly used for this purpose, not only to give a global survey of the components and their amounts, but also to precisely and accurately quantify specific target proteins.
Latest:
Chemical Analysis of Microscopic Fluorescent Materials by Dispersive 1064 Raman SystemRaman measurement on microscopic inclusions in fluorescent materials requires the ability to measure in small volumes, excellent throughput, and long wavelength excitation such as 1064 nm for fluorescence reduction.
Latest:
Using the Full Spectrum for Raman: From UV to NIRThe "inelastic scattering of light," or Raman effect, was observed in practice for the first time in 1928 by C.V. Raman for which he was awarded the Nobel Prize in 1930.
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An Investigation into the Use of Alternate Carrier Gases for the Determination of Volatile Organic Compounds in Water by GC–MSThis study focuses on United States Environmental Protection Agency (US EPA) Method 524.3 for volatile organic compounds (VOCs) in water using gas chromatography–mass spectrometry (GC–MS).
Latest:
Atmospheric Applications IFS 125HRBruker's IFS 125HR spectrometer is designed as an ultra-high resolution FT-IR spectrometer which provides outstanding performance for R&D laboratory application.
Latest:
Using the Full Spectrum for Raman: From UV to NIRThe "inelastic scattering of light," or Raman effect, was observed in practice for the first time in 1928 by C.V. Raman for which he was awarded the Nobel Prize in 1930.
Latest:
Macro ATR-FT-IR Spectroscopic Imaging of Dynamic ProcessesMacro attenuated total reflection FT-IR spectroscopic imaging is a powerful and underutilized tool. This article presents an overview of approaches and opportunities for using this method to study dynamic processes such as diffusion, sorption, crystallization, and dissolution.
Latest:
Using the Full Spectrum for Raman: From UV to NIRThe "inelastic scattering of light," or Raman effect, was observed in practice for the first time in 1928 by C.V. Raman for which he was awarded the Nobel Prize in 1930.
Latest:
Determination of Sodium Lauryl Sulfate and Sodium Laureth Sulfate in Commercial Body Care ProductsA method for quantifying the percent sulfate associated with sodium lauryl sulfate (also referred to as sodium dodecyl sulfate) and sodium laureth sulfate (also referred to as sodium lauryl ether sulfate) found in commonly used commercial body care products using FT-IR attenuated total reflectance (ATR) spectroscopy is outlined.
