April/May 2025

Molecule of an amide with a nucleophile attacking the carbonyl group. Generated by AI. | Image Credit: © udomsak - stock.adobe.com.

Carbonyl containing functional groups are strong infrared absorbers and a number of them are easy to identify by infrared spectroscopy. Here, we will review the spectra of ketone and carboxylic acids.

Fuel processing control room with a comprehensive digital interface system. Generated with AI. | Image Credit: © Srinard - stock.adobe.com.

United States Pharmacopoeia (USP) general chapter <1058> on Analytical Instrument Qualification (AIQ) now has a new title from a draft update for public comment: Analytical Instrument and System Qualification (AISQ). A new three-phase integrated lifecycle phase approach to qualification and validation is described. But will laboratories and suppliers implement it?

Refrigerator room. Factory style cold room ice. Generative AI. | Image Credit: © Aiakos - stock.adobe.com.

In this article, tunable diode laser absorption spectroscopy (TDLAS) is used to measure ammonia leakage, where a new denoising method combining empirical mode decomposition with the Savitzky-Golay smoothing algorithm (EMD-SG) is proposed to improve the signal-to-noise ratio (SNR) of absorbance signals.