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New Approach for Optimizing a Monoclonal Antibody Biotherapeutic in Different Formulations
September 1st 2009A prerequisite for a successful biotherapeutic formulation is one where the protein is stable and correctly folded. The new technique of dynamic multi-mode spectroscopy (DMS) was used to study the stability of a monoclonal antibody biotherapeutic formulated in acetate and lactate buffers. The samples were measured several times over a period of weeks and it became apparent that the antibody behaved differently as it aged in the two formulations, with the lactate formulation imparting greater robustness than the acetate.
Economical Maya2000 Pro Spectrometer Extends to VDUV
September 1st 2009Spectral measurements to 153 nm can be achieved easily and economically with the high-sensitivity Maya2000 Pro with Extra-Deep-UV Option. Nitrogen purging of the spectrometer helps to mitigate water and oxygen absorption in the vacuum ultraviolet.
Analysis of Migratory Elements in Toy Samples Using the Thermo Scientific iCAP 6200 ICP
September 1st 2009The analysis of toy samples for toxic trace elements has been undertaken for many years. However, a number of recent cases of toys contaminated with heavy metals has attracted global media attention. This has resulted in an increase in the number of toy manufacturers performing their own 'in-house' testing. This 'in-house' testing is not only to ensure regulatory compliance; it is also proving significantly more cost effective than outsourcing the analysis.
Rapid Micro-Sampling by ATR/FT-IR
September 1st 2009In ATR/FT-IR, magnified visual monitoring of a sample benefits many applications. For micro-sampling and defect analysis, viewing capabilities decrease overall measurement time by allowing the user to locate the desired sampling area quickly and enhance confidence in the collected data by assuring the sampling point. Visual changes in the sample also may be easily monitored during testing. As an example application, the ease of micro-sampling is shown through fiber analysis and the results are discussed.
A Comparison of Raman Analysis of Carbon Nanotubes
September 1st 2009A new Raman spectrometer system, innoRamâ„¢, has been developed to provide research-grade performance in either a lab or a mobile environment. The Raman analysis of carbon nanotubes using innoRam in comparison with a Raman spectrometer using a conventional front illuminated CCD demonstrates distinctive improvements for innoRam in both sensitivity and signal-to-noise ratio (SNR).
Raman Analysis of Low Concentration Ions in Water
September 1st 2009High sensitivity Raman analyzers could provide solutions for continuous and automated measurements of low concentration ions or molecules in aqueous solutions for applications in industries including biomedical, mining, agrichemical, pharmaceutical, cleaning, and environmental. As an example for similar applications, the quantitative analysis of low concentration sulfate ion in aqueous solution down to as low as 2.5 ppm by conventional (Non-SERS) Raman is demonstrated.
Low-Concentration Melamine Detection with the IdentifyIR Diamond ATR Spectrometer
February 1st 2009Detection of contaminants in consumer products is a critical public-safety need. One of the challenges of this type of detection is that the contaminant chosen is frequently designed to "fool" the routine product-safety testing performed. For example, melamine as the adulterant of choice to lower the cost of milk is because melamine contains nitrogen molecules.
Impact of Containers on Raw Material Verification Using a Handheld Raman Spectrometer
February 1st 2009Raman spectroscopy is a well-accepted, powerful tool for material identification, and the ability of a Raman spectrometer to acquire spectra through plastic and glass packaging materials protects sample integrity and greatly reduces analysis time.
Ruggedized NIR Spectrometers: Pharmaceuticals/Neutraceuticals/Food/Ag/PAT
February 1st 2009Confirming the water content of pharmaceuticals and food during processing is critical for GmP results. The ability to measure water content until recently has been a difficult challenge until now. As a result of developments in the telecom industry, NIR spectrometers offer highly repeatable, cost effective solutions.
Structure and Thermodynamics of an mAb Biotherapeutic in Different Formulations
February 1st 2009The new technique of dynamic multi-mode spectroscopy (DMS) was used to study the stability of a monoclonal antibody biotherapeutic formulated in acetate and lactate buffers. The samples were measured several times over a period of weeks and it became apparent that the antibody behaved differently as it aged in the two formulations, with the lactate formulation imparting greater robustness than the acetate.
UV-Vis Diffuse Reflectance of Thermochromic Materials Including Color-Changing Paint
February 1st 2009Some powders and rough surfaced solids change color as a function of temperature, a phenomenon known as thermochromism. Such phenomena can be effectively studied by UV-Visible spectroscopy in combination with a diffuse reflection accessory equipped with temperature-controlled reaction chamber, as demonstrated here with a thermal paint.
Analyzing Solar Cell Material Properties with Confocal Raman Microscopy
February 1st 2009Energy generation using photovoltaic devices is regarded as an important component in overcoming future energy shortages. This is reflected in a dramatic increase in photovoltaic production and demand. In the research and development of photovoltaic devices, the primary goals are to increase the conversion efficiency of the solar cells or to improve the production process. The following study describes the application of Confocal Raman Imaging for the analysis of stress fields around laser-drilled holes on a Si solar cell using the large area scanning capabilities of the WITec alpha500 Confocal Raman Microscope.
The AGE Reader, a Novel Tool for Noninvasive Cardiovascular Risk Assessment
February 1st 2009Cardiovascular diseases are among the most important causes of death in The Netherlands. It is of great importance to be able to detect these diseases at an early stage. However, current methods that use classical risk factors such as cholesterol and blood pressure do not come up to the mark.
The Analysis of Low Level Sulfur in Biodiesel According to ASTM D2622
February 1st 2009Global warming is seen as a growing problem across the world. One of the major contributing factors to global warming is greenhouse gas emissions and particulates emitted from automobiles. In an attempt to control the particulate emissions from motor vehicles, limits have been placed on the amount of elements such as Sulfur allowed in automotive fuels. Currently in the US, the EPA tier 2 regulations have set the limit for S in road fuels (Gasoline, Diesel and Biodiesel) at 150 ppm.
Analysis of Impurities in Silver by Spark Ablation Sampling, Combined with ICP-OES
February 1st 2009A method for the determination of elemental impurities in solid silver samples was developed using a spark ablation accessory in combination with ICP-OES. Detection limits at the sub-ppm level were achieved along with good accuracy and precision.
The New Orbis Micro-XRF Analyzer Series
February 1st 2009Building on more than 10 years of Micro-XRF experience, the Orbis spectrometer yields a system with excellent Micro-XRF capability while setting a new standard in analytical flexibility. The Orbis incorporates a unique motorized turret integrating video and X-ray optics allowing coaxial sample view and X-ray analysis. The turret can accommodate two additional collimators along with the X-ray optic for a total of three X-ray beam sizes to expand the Orbis analytical capabilities beyond traditional Micro-XRF analysis. Primary beam filters can be used with all spot sizes available on the turret to allow true XRF analytical capabilities in a micro-spot analysis. The working distance is increased to allow analysis over rougher sample topography without sacrificing signal intensity.
Complete Analysis of Carbon Black–Containing Rubbers
September 1st 2008Carbon black rubbers often contain multiple components, but are strongly absorbing in the infrared. The combination of Ge ATR, Advanced ATR correction and multi-component searching permits the full analysis of these important materials.
Miniature NIR: Improved Accuracy, Cost Savings
September 1st 2008With gas and diesel fuel prices rising, there is an increasing need to monitor online quality control and blending mixtures. The benefits include improved accuracy in blending mixtures, solid state reliability, lifetime calibration and fraud avoidance.
Monitoring Cure Characteristics of a Thermoset Epoxy by ATR/FT-IR
September 1st 2008Some ATR / FTIR applications require a high performance, robust, and versatile accessory to accommodate difficult materials or high temperatures. As an example, the curing of a thermoset epoxy is evaluated and results are discussed.