Application Notes

A novel optical focusing method overcomes sampling hurdles associated with Raman devices that are based on a dispersive design. Raster Orbital Scanning (ROS) samples the target materials while maintaining high resolution and minimizing the power buildup of a tightly focused laser typical in Raman applications.

The characterization of graphene with combined Raman-AFM imaging provides a nondestructive method to extensively investigate its properties.

Pharmaceuticals manufactures the world over are seeking more efficient ways to perform raw material analysis while complying with stringent global regulations.

Mercury is a toxic, persistent pollutant found in many native ores rich in copper, silver and gold. As such ores are processed mercury can be released to the environment.

Single reaction chamber microwave digestion enables a chemist to digest up to 15 different specialty chemical samples simultaneously at temperatures as high as 300 ?C, greatly simplifying the workflow while maintaining superior quality digestions.

Yeast suspensions were dried and analyzed via FT-IR using an automated transmission sampling accessory. Up to six-fold sampling capacity increase may be realized through automation.

The analysis of coal is demonstrated, with specific emphasis on the measurement of Na2O, using a Cartesian geometry energy dispersive X-ray fluorescence (EDXRF) spectrometer employing the Fundamental Parameters (FP) approach.

Knowledge of atmospheric ammonia concentrations is important, but ammonia is difficult to measure. We report here on the development of a low-cost ammonia measuring differential optical absorption spectroscopy (DOAS) instrument, based on a small sized and low priced spectrograph.

Low concentration natural methanol exists in most alcoholic beverages and usually causes no immediate health threat.

Pharmaceutical samples spiked with several heavy metals were prepared for ICP-MS analysis using microwave digestion following the protocols in proposed USP chapters <232> and <233>. The results of the spike recovery study are discussed.

Confocal Raman imaging opened the door for many applications in Raman spectroscopy and imaging that were previously unavailable for measurement with conventional (non-confocal) Raman methods.

Owing to technological improvements spurred on by the telecommunications boom of the last decade, Raman spectroscopy has become much more accessible to users in all application areas, including agricultural, forensic, pharmaceutical, biomedical, and others.

Although Raman spectroscopy is an excellent analytical tool, Raman signals are often weak and traditional slit spectrometers typically have poor optical throughput, limiting their effectiveness in low light level setups.

Moxtek's ULTRA-LITE X-ray source is a very small self contained X-ray source (X-ray tube and high voltage power supply) for use in portable X-ray applications, such as the handheld X-ray fluorescence (XRF) spectrometers. This note demonstrates that this X-ray source has a stable and repeatable X-ray flux output over time, which is vital for the precision of the calibrated XRF measurements.

The measurement of trace elements is important across a wide variety of materials characterization problems. When measuring small glass fragments collected from crime and accident scenes, forensics experts analyze trace strontium (Sr) and zirconium (Zr) typically unintentionally incorporated into the glass during manufacturing as one point of identification or comparison.

Multiple reflection ATR is ideal for detecting miniscule levels of components in solutions. If one component is volatile, trace analysis can be simplified by allowing the volatile liquids to evaporate.

The miniDOAS: Low Cost, High Performance Contactless Ammonia Measurements

Transportable Dual-Band Raman System for Fuel Analysis

Probing the Detection Limits of Concentrated Multiple Reflection ATR Spectroscopy

Improved Sensitivity with the New Apollow XRF ML-50 Detector on the Orbis Micro-XRF Analyzer

Determination of Low Concentration Methanol in Alcohol by an Affordable High Sensitivity Raman Instrument

Bruker Daltonics, Inc.

Proton OnSite

Experimental data show the crystal dimensions of an ATR-FT-IR sampling accessory influence the usable spectral range. An expanded range germanium crystal is introduced for the measurement of high refractive index samples.

Single reaction chamber (SRC) microwave digestion offers multiple benefits over traditional dry ashing for the sample preparation of heavy crude oils for trace metals analysis. These include increased sample throughput, reduced risk of contamination, more complete digestion and retention of volatile analytes.

Quantifying protein stability is of fundamental importance in many areas of biomolecular research. The thermodynamic stability of a protein is reflected by a change in Gibbs free energy, ?G?, characterizing the equilibrium transition from a folded state, to an ensemble of unfolded, denatured states. In order to study ?G?, the folding equilibrium needs to be shifted towards the unfolded states which can be achieved by several different methods including the addition of chemical denaturants such as guanidinium chloride (GdnHCl).

Biological tissues and other materials often autofluoresce at near-infrared wavelengths, prohibiting Raman acquisition. New, dispersive Raman systems at 1064 nm allow fluorescence-free measurement in similar integration times.

Moxtek's ULTRA-LITE X-ray source is a very small self contained X-ray source (X-ray tube and high voltage power supply) for use in portable X-ray applications, such as the handheld X-ray florescence (XRF) spectrometers. This note demonstrates that this X-ray source has a stable and repeatable X-ray flux output over time, which is vital for the precision of the calibrated XRF measurements.

Building on more than 10 years of Micro-XRF experience, the Orbis spectrometer yields a system with excellent Micro-XRF capability while setting a new standard in analytical flexibility. The Orbis incorporates a unique motorized turret integrating video and X-ray optics allowing coaxial sample view and X-ray analysis. The turret can accommodate two additional collimators along with the X-ray optic for a total of three X-ray beam sizes to expand the Orbis analytical capabilities beyond traditional Micro-XRF analysis.

Elemental analysis of aqueous solutions into the low ppm and sub-ppm concentration ranges is demonstrated, using the advanced Cartesian geometry Rigaku NEX CG Energy Dispersive X-ray Fluorescence (EDXRF) spectrometer in conjunction with the patented UltraCarry? sample preparation technique.