Agilent

Articles

A Practical Guide To Elemental Analysis of Lithium Ion Battery Materials Using ICP-OES

Join this symposium to how to optimize dissolution testing, understand how transmission Raman spectroscopy can be used in drug discovery and development workflows, and more!

https://www.spectroscopyonline.com/spec/a-workflow-approach

Spectroscopy and chromatography play key roles in the workflows of pharmaceutical and bioprocessing QA/QC labs. Understanding the importance of these tools in raw materials identification, content uniformity, and other workflows provides critical quality attributes (CQA) in a regulated environment. High-performance liquid chromatography (HPLC) is a proven tool for the analysis of critical process parameters (CPP) of biotherapeutics.



Understand how transmission Raman spectroscopy can be used in drug discovery and development workflows

Learn how to optimize dissolution testing

Explore the use of Agilent’s FTIR and spatially offset Raman spectrometers (SORS) for raw materials identification (RMID)

The application of on-line HPLC to monitor and control CQA in bioprocessing

Ken Boda, Dissolution Specialist, Agilent



Dissolution is a key test to ensure that a drug is safe and effective and is the only test that can assess a formulation’s performance. To have meaningful dissolution data, it is critical to ensure reproducibility of the dissolution apparatus and procedures. We will discuss optimizing the dissolution to bring about greater accuracy and precision, fewer dissolution failure investigations, and achieving higher throughput.



Optimizing Dissolution Testing Integration of On-line HPLC as a PAT Tool for CQA Monitoring and Control in Bioprocessing

Stacy Shollenberger, Senior Marketing Manager, Process Analytical Technologies, Millipore Sigma & Daniel Kutscher, Product manager, Strategic Marketing, Agilent Technologies



High-performance liquid chromatography (HPLC) is a proven tool for the analysis of critical process parameters (CPP) and critical quality attributes (CQA) of biotherapeutics. Historically, HPLC has been performed off-line—a process that can take days or weeks to complete. By moving HPLC to the manufacturing floor as an on-line process analytical technology (PAT) tool, relevant data can be accessed in a matter of minutes. In this webinar, we highlight an initial use case demonstrating the utility of on-line HPLC to monitor and control antibody aggregation levels in bioprocessing. The implementation of PAT enables continuous manufacturing and empowers industry progress towards Bioprocessing 4.0.



Raw Material Identification and Verification in Compliant Environments with FTIR and Raman Spectroscopy

Yanqia Wang, Application Engineer, Molecular Spectroscopy, Agilent Technologies



Raw material identification (RMID) or verification is a common QA-QC practice in complaint environments with tremendous impact on customer safety as well as speed and cost of production. RMID has become an important application field of FTIR and Raman spectroscopy. Today’s RMID can occur either in the field and in-lab, which raise new challenges. Agilent’s compact portable FTIR and spatially offset Raman spectrometers (SORS) provide a great combination with versatile sampling interfaces and spectral process capabilities, which can offer great convenience, stability, and high-throughput solution to the RMID applications in compliant environments.



Embracing the UV-Vis QA/QC Needs of a Pharma/BioPharma Laboratory

Mark Fisher, Application Engineer, Molecular Spectroscopy, Agilent Technologies



The UV-Vis QA/QC needs of a pharma/biopharma laboratory range from the simple (an absorbance measurement at a single wavelength) to the complex (a thermal melt, also known as an absorbance verses temperature measurement). One of the challenges for a lab is deciding between a measurement-specific instrument or an instrument designed to perform a variety of measurements equally well. Agilent has two UV-Vis spectrophotometers that provide the pharma/biopharma the flexibility to meet their current and future needs even in a compliant environment.



Dissolution Product Specialist
Agilent Technologies

Ken joined Varian (now Agilent) in 2005 as an applications engineer and is now a dissolution product specialist. Prior to working at Agilent, he worked in pharma, specializing in dissolution testing and method development. As a dissolution product specialist, Ken works with customers in determining the best systems for their needs and optimizing their workflows. He has also helped educate customers on dissolution science through webinars, the Dissolution Discussion Group, LinkedIn, and other channels.




Senior Marketing Manager, Process Analytical Technologies
Millipore Sigma

Stacy Shollenberger holds an MS degree in biochemistry from the University of Virginia and an MBA from Penn State University. She has over 12 years of experience in analytical and bioanalytical product and method development. Currently, Stacy is a senior manager of process analytical technologies (PAT) at MilliporeSigma, the life science business of Merck KGaA, Darmstadt, Germany, and is responsible for defining the PAT strategy to move testing from traditional off-line quality control (QC) to QC on the bioprocessing floor.




Product Manager, Strategic Marketing
Agilent Technologies

Dr. Daniel Kutscher is a biochemist and experienced life-science professional with global responsibilities as a product manager for analytical HPLC. Daniel received his Ph.D. in 2011 from Justus-Liebig-University in Giessen, Germany under the supervision of Prof. Alfred Pingoud. After completing his Ph.D., he moved to New York and worked until 2018 as an HPLC product specialist, supporting customers in various industries. Daniel currently works for Agilent Technologies as a product manager - strategic marketing with a strong focus on better connecting the analytical with the (bio-) process world.




Application Engineer, Molecular Spectroscopy
Agilent Technologies

Dr. Yanqia Wang started working for Agilent Technologies Inc. as an FTIR application engineer in 2013, providing pre- and post-sale application support. The products he covers from benchtop FTIR microscopes to various mobile FTIR spectrometers. Dr. Wang received his Ph.D. of analytical chemistry from Duke University in 2004, doing dynamic IR spectroscopy research. Then he joined Fitzpatrick Center for Photonics at Duke University, doing tissue Raman spectrometer instrumentation. Since 2007, Dr. Wang worked for Avery Dennison Corp. as a spectroscopist, providing molecular analytical support to the research and development.




Application Engineer, Molecular Spectroscopy
Agilent Technologies

Mark Fisher graduated from the University of Nebraska-Lincoln in 1982 with a Doctorate in Chemistry with an emphasis in analytical chemistry. He has been with Agilent for 29 years. His duties include pre-sales support functions such as application support, demonstrating spectrophotometers and accessories, and training of sales force.



Webcasts

Webinar Date/Time: Thu, Feb 23, 2023 11:00 AM EST

Tools for the Pharma QA/QC: A Workflow Approach

Agilent Technologies’ ICP-OES system creates robust testing methods that easily overcome various challenges presented by novel functional food and supplement applications.

ICP-OES and Elemental Analysis of Dietary Supplements and Superfoods

Join us to learn about better workflows for UV-vis analysis, to improve efficiency in data collection and sample throughput with simultaneous data collection, and how to develop sample analysis methods for determination of material properties like concentration and melting temperature.

https://www.spectroscopyonline.com/spec/melts

UV-Vis spectrometers are very flexible instruments, with the ability to perform several different qualitative and quantitative sample measurements. Besides performing basic scans, applications can include creating calibration curves of absorbance versus concentration to identify unknown samples, measuring absorbance over time to study reactions, and studying absorbance as a function of temperature to perform melt experiments.
In this webinar, improved workflows for UV-Vis spectroscopy will be discussed. Discover how to develop Beer-Lambert Law calibration curves for determining the concentrations of unknown BSA samples as well as how to how to monitor thermal melts and chemical reactions using UV-Vis spectroscopy. For the examples discussed in this presentation, an Agilent Cary 3500 UV-Vis spectrophotometer will be used. The benefits of data collection across eight cuvette positions and measuring up to four temperature experiments, all simultaneously, will be explored. The samples that will be discussed here were run using an integrated air-cooled Peltier system allowing for fast data ramping possibilities as well as a xenon flash lamp achieving a data collection rate of 250 points per second.




Build a better workflow for improving efficiency in data collection and sample throughput with simultaneous data collection

Develop sample analysis methods for determination of material properties like concentration and melting temperature


Molecular Spectroscopy Applications Scientist
Agilent Technologies


 has a PhD in Physics from Georgetown University in Washington, DC, and started with Agilent in 2021 as a Molecular Spectroscopy Application Scientist. In his graduate work, Scott studied nanoparticle formation and growth for a variety of applications.Projects that he worked on include developing processes to deposit and characterize semiconducting molecular nano-cocrystals for use in optoelectronic devices as well as controlling polymer nanoparticle size through rapid mixing conditions.

Webinar Date/Time: Thu, Dec 15, 2022 11:00 AM ESTJ

Improved UV-Vis Applications: From Simultaneous Measurements to Fast Thermal Melts

https://www.spectroscopyonline.com/spec/8700

Microplastics are fast coming into focus as we are beginning to understand just how far these man-made products have made their way into ecosystems and food chains alike. While regulators are trying to understand the extent and toxicity of the problem, researchers and analytical methods bodies are working towards standardized analytical solutions to characterize these particles in terms of chemical identity, size, and shape.

Mid-infrared and Raman spectroscopy are fast emerging as leading techniques for this work. They are non-destructive and effective, and while they have benefits over traditional methods, they are neither fast nor simple. The Agilent 8700 LDIR Chemical Imaging system with a fully automated workflow for microplastics analysis changes this. It provides all the benefits of mid-infrared spectroscopy in a simple-to-use and fast solution. The latest development is the capacity to conduct this analysis directly on the filter used as the last step in sample preparation, increasing ease of use, speed, and accuracy.




Analysis direct on filters with a fast and simple automated workflow for microplastics

How to optimize microplastics analysis with QCL (Quantum Cascade Laser) based infrared imaging

How to optimize microplastics analysis with the 8700 LDIR

Recent workflow developments in the 8700 LDIR including on-filter analysis

Progress towards standardized methods and testing requirements

Microplastics analysts from commercial, QA, or research labs seeking faster and easier analysis methods

Those interested in contamination of wastewater, seawater, freshwater, air, sediments, and food (such as fish, shellfish, crustaceans, and bottled water)


Product Manager: IR Imaging
Agilent Technologies

 has worked with applied analytical techniques for more than 20 years in positions from laboratory technician to product manager. Working across various industries from food and agriculture to environmental and pharmaceuticals has given Darren a unique and broad experience. Over these 20 years, Darren has developed a keen interest in taking complex analytical techniques and developing systems and workflows to make them simple. Of particular interest has been removing the potential for the human factor to influence results, which is removing or limiting the potential for analyst error.

North America: Wednesday, November 16, 2022 at 11am PST | 1pm CST | 2pm EST
Europe: Thursday, November 17, 2022, at 11am BST | 12pm CET
Asia: Thursday, November 17, 2022, at 10:30 IST | 1pm  SGT | 2pm JST | 4pm AEST
Fast, easy, and accurate analysis of microplastics is a key need of anyone with an interest in this area. With the capacity to conduct this analysis directly on the filter in the Agilent 8700 LDIR for microplastics, this analysis has now reached a new level.

Agilent

Articles

A Practical Guide To Elemental Analysis of Lithium Ion Battery Materials Using ICP-OES

Tools for the Pharma QA/QC: A Workflow Approach

ICP-OES and Elemental Analysis of Dietary Supplements and Superfoods

Improved UV-Vis Applications: From Simultaneous Measurements to Fast Thermal Melts

Microplastics analysis just got easier: Analysis direct on-filter

High Volume Optical Component Testing

Evaluation of Photometric Accuracy in the Near Infrared Region Using Metal-on-Quartz Filters

Application Note: The measurement of high optical densities (up to 8 Abs) in the near-infrared

Spectrophotometric Methods of Refractive Indices Measurement

Unattended, Automated Measurements of Optical Components in a Production Environment