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The Detection of Biomarkers and Cocaine in Fingernails Using Attenuated Total Reflectance Fourier Transform Infrared SpectroscopyATR-FT-IR spectroscopy can provide rapid and portable measurements in forensic applications, demonstrating its ability to rapidly detect biomarkers and the presence of cocaine in fingernails.
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Fluorescence Quenching Effects of Fe3+ Ions on Carbon DotsThe “selective fluorescence quenching effects” of Fe3+ ions on carbon dots are examined to gain a more comprehensive understanding of the interactions of metal ions with a variety of fluorescent materials.
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Cold-Hot Nature Identification of Chinese Medicine Based on an Ultraviolet Chemical FingerprintA model has been developed to predict the “cold” or “hot” nature of Chinese medicines based on UV spectral data.
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Determining Nitrophenol Isomers Using Raman SpectroscopyIn this study, the nitrophenol isomers, in solid and liquid phases, were analyzed using Raman spectroscopy, laying the groundwork for determining nitrophenol isomers in environmental monitoring with this technique.
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In-situ Detection of Rice Using Laser Induced Breakdown Spectroscopy and Machine LearningThis research investigates the application of laser-induced breakdown spectroscopy (LIBS) and machine learning (ML) for detecting elemental composition of food, using rice as an example.
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Imaging of Trace Elements Using Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry: Emerging New ApplicationsMetallomics seeks to understand the metallobiochemistry of cells and organisms in health and disease. This article explains the principle of laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) for imaging applications and highlights its potential to provide additional insights in bioanalysis and metallomics.
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Recognition of Process Degree for Gardeniae Fructus Praeparatus Based on Hyperspectral Data and Neural NetworkIn this study, a hyperspectral (400–1000 nm) system was utilized to acquire hyperspectral images of gardeniae fructus (GF) and construct a data set containing 3146 spectral data.
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Shedding Light on DNA Analysis: Multiplexed Detection and Identification Using Fluorescence Lifetime Methods (PDF)This article provides a review of using both time- and phase-resolved fluorescence for DNA analysis in both sequencing and microarray applications.
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Handheld FT-IR Spectrometers: Bringing the Spectrometer to the SampleThis article focuses on the emergence of handheld, portable FT-IR spectrometers and the implications with respect to applications and use.
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Ultralow Detection of Estrogenic Compounds by GC–NCI-MS-MSA number of clinical situations now call for high-sensitivity measurement of estrogens, including monitoring during female hormone replacement therapy, antiestrogen treatment, and estrogen deficiency in men. Traditional immunoassay methods and liquid chromatography–tandem mass spectrometry (LC–MS-MS) do not provide the sensitivity and selectivity required for these applications. In contrast, a gas chromatography–negative chemical ionization–tandem mass spectrometry (GC–NCI-MS-MS) platform can provide detection limits below 1 pg/mL when used in conjunction with the appropriate derivatization protocol, with very short cycle times.
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The Importance of Rigorous Instrument Calibration for Successful Sample Identification and Instrument-to-Instrument ReproducibilityOver the last few years, Raman has made the transition from a technique used solely in a research environment to one that is now seen as a powerful tool for routine analytical use. Raman spectroscopy now is used widely for sample identification in fields as diverse as forensics, QA/QC, art conservation, defect analysis, and failure analysis. This has imposed new demands on the technique for reproducibility and stability. Successful sample identification takes advantage of the extensive spectral libraries and sophisticated search algorithms that have been developed in recent years. However, in order to be able to cross-correlate experimental and library spectra with any degree of confidence, it is critical that the Raman spectrometers used to collect the spectra are calibrated rigorously. It is likewise critical for QC applications that spectra collected on one instrument can be compared reliably with spectra collected on other instruments and that results remain constant when collected over extended periods..
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Versatile Protein Identification Using AP-MALDI Ion Trap Mass Spectrometry (PDF)New developments in matrix-assisted laser desorption ionization (MALDI) technology enable decoupling of the ionization source from the time-of-flight mass analyzer for operation at atmospheric pressure (AP-MALDI). This technique also can be integrated with other types of mass analyzers, such as the ion trap.
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Comprehensive Analysis of Persistent Organic Pollutants in Complex Matrices 48 Using GC with High-Performance TOF-MSThe combination of GC with time-of-flight (TOF)-MS proves to be a successful approach for the challenging analysis of persistent organic pollutants in complex matrices such as sediment and fish samples.
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Multitargeting PesticidesThe usefulness of liquid chromatography–mass spectrometry–mass spectrometry (LC–MS-MS) methods for the unambiguous identification and quantification of pesticides in complex matrix samples is well known. Triple-quadrupole systems have proven to be useful for this task because of their high specificity in MS-MS mode and their low detection limits. However, working in MS-MS mode makes any MS system blind to other compounds of interest.
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The Benefits of ICP-MS for the Determination of Toxic and Nutritional Elements in the Cannabis Family of Flowering PlantsThe wide dynamic range of ICP-MS allows it to be used for the simultaneous determination of parts-per-billion levels of heavy metals including lead, arsenic, cadmium, and mercury, together with high parts-per-million levels of nutritional elements, such as phosphorus, calcium, potassium, and magnesium.
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Molecular Spectroscopy Workbench Applications of Mid-IR Spectroscopy to the Pharmaceutical Process Environment (PDF)This installment examines one of the key differences between the Near-IR and Mid-Range IR and highlights a couple of applications where Mid-IR can be effectively employed as a process analytical technology (PAT).
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Liquid Chromatography Coupled with Tandem Mass Spectrometry for Clinical ApplicationsThe authors discuss the emergence of liquid chromatography coupled with tandem mass spectrometry as a complementary method to traditional methodology used for clinical applications.
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Using High-Resolution LC–MS to Analyze Complex SampleThe authors discuss the use of high-resolution LC-MS to analyze complex samples in regulated environments such as food and animal-feed analysis.
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Single-Particle Spectroscopy on Conducting Polymer-Fullerene Composite Materials for Application in Organic Photovoltaic DevicesThe study of the photophysical and optoelectronic properties of a functioning conducting polymer device is complicated and is hampered by the complex nanostructure and morphology of the conducting polymer materials in these devices. Here we discuss an approach to investigate this issue in terms of bulk-heterojunction organic photovoltaic devices.
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Review of the Third North American Symposium on Laser-Induced Breakdown Spectroscopy (NASLIBS) 2011 ConferenceThis year's theme, "Transition from Research to Application," emphasized important developments in the field application of LIBS and fundamental knowledge of the technique.
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A New Perspective on the Challenges of Mass SpectrometryThe authors discuss the challenges presented by the many new applications of mass spectrometry.
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Optimized ICP-MS Analysis of Elemental Impurities in Semiconductor-Grade Hydrochloric AcidA closer look at the use of a cell-based ICP-MS approach that utilizes ion–molecule chemistry to reduce many of the traditional spectral interferences seen in the analysis of high-purity hydrochloric acid used in manufacturing integrated circuits and semiconductor devices
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Multitargeting PesticidesThe usefulness of liquid chromatography–mass spectrometry–mass spectrometry (LC–MS-MS) methods for the unambiguous identification and quantification of pesticides in complex matrix samples is well known. Triple-quadrupole systems have proven to be useful for this task because of their high specificity in MS-MS mode and their low detection limits. However, working in MS-MS mode makes any MS system blind to other compounds of interest.
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Ultratrace Aluminum Analysis of Nutritional Intravenous Solution Components in 1-Propanol Using GFAAS (PDF)This article describes how ultratrace aluminum analysis of two nutritional intravenous solution components with limited water solubility can be performed by graphite furnace atomic absorption spectroscopy (GFAAS) with dissolution in 1-propanol.
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From Tablets to Teeth: Complete Raman ImagingRaman imaging has moved on. It is now possible to capitalize on the wealth of information available from a Raman spectrum by imaging materials over large areas, with the spatial resolution, spectral resolution, and laser excitation parameters tailored to suit each application. Raman experiments and images from a diverse range of samples are presented.
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Complete Multielemental Analysis of Environmental and Geological Samples Using CCT-Based ICP-MSThe authors discuss the ICP-MS method, its usability in environmental and geological analysis and relevant regulations, and how to address its limitations.
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A Comprehensive Study of WSe2 Crystals Using Correlated Raman, Photoluminescence (PL), Second Harmonic Generation (SHG), and Atomic Force Microscopy (AFM) ImagingUsing confocal Raman imaging and other advanced measurement techniques, we study the localized strain characteristics of tungsten diselenide (WSe2), an important nanomaterial used for optoelectronic device applications.
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Synthesis and Structural Elucidation of Impurities in Ramipril TabletsIn this article, the authors take a look at the identification, synthesis, and characterization of impurities in Ramipril tablets.
