Authors
Latest:
Software Tools for 3D Raman ImagingNewly developed software tools provide various functions for the acquisition, evaluation, and processing for high-resolution 3D Raman images.
Latest:
Increasing the Enhancement of SERS with Dielectric Microsphere ResonatorsSurface-enhanced Raman spectroscopy (SERS) is a widely studied technique capable of adding single-molecule detection capability to the rich information provided by Raman spectroscopy. in this aricle, the authors show an additional system gain of more than two orders of magnitude to SERS by using a dielectric microsphere resonator to capture and excite the target system.
Latest:
Identification of a Low-Abundant Biomarker in Human Serum Using nanoLC–LIT-TOF MS and Information-Based Acquisition TechniquesSerum protein profiling using mass spectrometry (MS) is one of the most promising approaches for biomarker identification. The authors adopted a nano liquid chromatography (nLC)–linear ion trap time-of-flight (LIT-TOF) MS system and newly developed software known as information-based acquisition (IBA) to identify biomarkers in human serum. IBA is a data processing protocol for repetitive MS analyses. Peptides selected for the first-pass MS-MS analysis are automatically excluded from the MS spectrum such that subsequent MS-MS analyses are performed on different peptides to minimize overlapping analyses, resulting in the identification of relatively low-abundant peptides.
Latest:
53rd Annual ASMS Wrap UpA review of the five-day conference dedicated to promoting mass spectrometry and its allied topics held earlier this month in San Antonio, TX.
Latest:
Polar Vapor-Enhanced Separations with Planar Differential Mobility Spectrometry-Mass SpectrometryA brief historical overview of DMS, followed by a synopsis of the instrumentation, physics, and chemistry behind the separation principles
Latest:
Detecting Bacillus Spores by Raman and Surface-Enhanced Raman (SERS) SpectroscopyRaman spectroscopy has been employed to detect Bacillus cereus spores, an anthrax surrogate, collected from a letter as it passed through a mail sorting system. Raman spectroscopy also has the ability to identify many common substances used as hoaxes. A three-step method also is described for the detection of dipicolinic acid extracted from surface spores by SERS.
Latest:
A High-Volume, High-Throughput LC–MS Therapeutic Drug Monitoring SystemTherapeutic drug monitoring is performed routinely by liquid chromatography–mass spectrometry (LC–MS) using instrumentation and methods originally developed and systematically configured for the high-volume, high-throughput analysis of drugs of abuse. An example of LC–MS monitoring of the drug clozapine and its metabolite, desmethylclozapine, is detailed along with a description of the overall system architecture, workflow, and maintenance routines that support a large-scale clinical therapeutic drug monitoring program. The relative advantages of LC–MS over immunoassay and LC–UV, the current standard techniques for therapeutic drug monitoring, are discussed in the light of these results.
Latest:
IMS for Cleaning Verification (PDF)The need to verify cleaning between manufacturing runs presents a special challenge to the analytical chemist. In this article, the principles of ion mobility spectrometry are described, its performance is compared to HPLC for the analysis of cleaning validation samples, and findings are presented from a study to establish the feasibility of using IMS in validating a cleaning verification method.
Latest:
Considerations for Primary Vacuum Pumping in Mass Spectrometry Systems (PDF)Mass spectrometry systems have specific vacuum requirements. New developments in oil-free, or dry, primary vacuum pumps have been introduced recently and are discussed in this article with respect to capacity, throughput, and specific pumping requirements for process gases.
Latest:
Carbon Structure and Raman SpectroscopyIn this column, we will describe what is known about the structures of these materials and how Raman spectroscopy can characterize them.
Latest:
Considerations for Primary Vacuum Pumping in Mass Spectrometry Systems (PDF)Mass spectrometry systems have specific vacuum requirements. New developments in oil-free, or dry, primary vacuum pumps have been introduced recently and are discussed in this article with respect to capacity, throughput, and specific pumping requirements for process gases.
Latest:
How Using Raman Spectroscopy and SIMPLISMA Can Accelerate the Study of Polymorphs: A Case Study Using Carbamazepine (PDF)The authors show how a multivariate curve resolution algorithm, called SIMPLe-to-use Interactive Self-modeling Mixture Analysis (SIMPLISMA), can facilitate the quantitative and qualitative analysis of difficult samples, and apply the algorithm to a technically challenging Raman spectra series for carbamazepine polymorphs.
Latest:
Considerations for Primary Vacuum Pumping in Mass Spectrometry Systems (PDF)Mass spectrometry systems have specific vacuum requirements. New developments in oil-free, or dry, primary vacuum pumps have been introduced recently and are discussed in this article with respect to capacity, throughput, and specific pumping requirements for process gases.
Latest:
Unilateral Nuclear Magnetic Resonance for Quality Control: The NMR-MOUSE (pdf)This article discusses the principles of unilateral nuclear magnetic resonance with applications to elastomers and nondestructive in situ inspection of a wet fresco from ancient Rome.
Latest:
FT-IR Spectroscopy: An Advanced Tool for Studying Biomedical Problems (PDF)The authors describe several applications of FT-IR spectroscopy in the biomedical sciences, including characterization of healthy and neoplastic human skin samples affected by two kinds of cancers, and examination of liver damage and regeneration caused by carbon tetrachloride.
Latest:
Unilateral Nuclear Magnetic Resonance for Quality Control: The NMR-MOUSE (pdf)This article discusses the principles of unilateral nuclear magnetic resonance with applications to elastomers and nondestructive in situ inspection of a wet fresco from ancient Rome.
Latest:
In-Line Process Analysis of Residual Moisture in a Fluid Bed Granulator-Dryer Using NIR Spectroscopy (PDF)The authors describe the in-line moisture measurement of a pharmaceutical granulation of lactose, microcrystalline cellulose, and crospovidone in a fluid bed granulator-dryer using top sprayed granulating liquid. A near-infrared (NIR) prediction model was developed for moisture on spectra collected during a calibration run. Subsequent granulations were analyzed for moisture content real-time throughout the granulation and drying process using the NIR process instrument.
Latest:
IMS for Cleaning Verification (PDF)The need to verify cleaning between manufacturing runs presents a special challenge to the analytical chemist. In this article, the principles of ion mobility spectrometry are described, its performance is compared to HPLC for the analysis of cleaning validation samples, and findings are presented from a study to establish the feasibility of using IMS in validating a cleaning verification method.
Latest:
Considerations for Primary Vacuum Pumping in Mass Spectrometry Systems (PDF)Mass spectrometry systems have specific vacuum requirements. New developments in oil-free, or dry, primary vacuum pumps have been introduced recently and are discussed in this article with respect to capacity, throughput, and specific pumping requirements for process gases.
Latest:
Considerations for Primary Vacuum Pumping in Mass Spectrometry Systems (PDF)Mass spectrometry systems have specific vacuum requirements. New developments in oil-free, or dry, primary vacuum pumps have been introduced recently and are discussed in this article with respect to capacity, throughput, and specific pumping requirements for process gases.
Latest:
Unilateral Nuclear Magnetic Resonance for Quality Control: The NMR-MOUSE (pdf)This article discusses the principles of unilateral nuclear magnetic resonance with applications to elastomers and nondestructive in situ inspection of a wet fresco from ancient Rome.
Latest:
Considerations for Primary Vacuum Pumping in Mass Spectrometry Systems (PDF)Mass spectrometry systems have specific vacuum requirements. New developments in oil-free, or dry, primary vacuum pumps have been introduced recently and are discussed in this article with respect to capacity, throughput, and specific pumping requirements for process gases.
Latest:
Sampling Accessories for the High-Throughput Analysis of Combinatorial Libraries Using Spectral Imaging (PDF)This article describes several sampling accessories, designed by the authors, that allow a variety of combinatorial systems to be analyzed.
Latest:
Analysis of Fusarium Toxins Using LC?MS-MS (PDF)The authors present an MS technique that reliably detects several types of fungal mycotoxins, and compare electrospray ionization and atmospheric chemical ionization techniques.
Latest:
Test of an In Vivo Method to Detect Chloroplast Division in Crop Plants, Part III: Statistical Proofs of Observation and General Utility of the Method (PDF)This article is the third installment in a series about a novel spectrofluorometric method that allow for in vivo observation of the division of chlorplast populations in leaves of Arabidopsis thalania.
Latest:
Tech Note: High-Resolution Ultrasonic Spectroscopy for Analysis of Chemical Reactions in Real Time (PDF)This article discusses direct real-time monitoring of chemical reactions, an important tool in industrial processes in industries such as chemical, biotechnology, food, and pharmaceutical.
Latest:
FT-IR Microscopic Analysis of Polymer Laminate Samples Including Transmission and ATR SpectroscopyPolymer laminates typically make complex samples for infrared analysis, comprising multiple layers with defined thicknesses, in some cases less than 10 µm. When measuring extremely narrow laminate layers, the use of attenuated total reflectance (ATR) may provide improved spectra of the laminate cross-section, because ATR microscope objectives offer a greater spatial resolution than transmission due to additional magnification. This paper details the preparation of polymer laminate sample cross-sections and the collection of transmission and ATR spectra of various layers. Further analysis of the laminate spectra will also be explored utilizing a multivariate curve resolution (MCR) algorithm. An example laminate sample is examined utilizing all the tools available on a standard FT-IR microscope.
Latest:
An Enhanced Approach to Analytical Instrument and System QualificationUnited States Pharmacopoeia (USP) general chapter <1058> on Analytical Instrument Qualification (AIQ) now has a new title from a draft update for public comment: Analytical Instrument and System Qualification (AISQ). A new three-phase integrated lifecycle phase approach to qualification and validation is described. But will laboratories and suppliers implement it?
Latest:
Detection of g-Hydroxybutyrate and g-Butyrolactone by Ion Mobility Spectrometry (PDF)The authors discuss g-hydroxybutyrate (GHB), a drug of abuse that is not detected in the drug-detection mode or positive polarity of commercial ion mobility spectrometers, but can be detected by ion mobility spectrometry (IMS) instruments in negative mode.
