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FACSS 2009 PreviewSpectroscopy previews the 36th FACSS, to be held October 18–22, 2009, in Louisville, Kentucky.
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Savitzky–Golay Smoothing and Differentiation Filter of Even Length: A Gram Polynomial ApproachIn various fields such as signal processing, imaging processing, analytical chemistry, and spectroscopic analysis, smoothing and differentiation is important and necessary. With a matrix approach, the Savitzky–Golay smoothing and differentiation filter was extended recently to even length. In this article, a more general approach is proposed for convenient computation.
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Reducing the Impact of Spectral Interferences on the Determination of Precious Metals in Complex Geological Matrices Using DRC ICP-MSThe potential for signal drift, matrix suppression, and spectral interference, in addition to demanding sample preparation, can make geological matrices some of the most difficult to analyze by conventional inductively coupled plasma-mass spectrometry.
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Acronyms in Mass SpectrometrySpectroscopy columnist Ken Busch once again brings readers his comprehensive list of common acronyms used in the field of mass spectrometry.
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Enhancing Mass Spectral Formula Determination by Heuristic RulesA new approach to enhancing the performance of formula identification of true unknowns beyond high mass and spectral accuracy was evaluated. Three heuristic rules on upper limits and ratios of elements were tested for their effectiveness in filtering out false positive formulas with both high- and low-resolution mass spectrometry data. The rule on elements' upper limits was found to be the most effective one in eliminating incorrect formulas.
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Rapid, Cost-Effective, and Routine Biomedical Analysis Using ICP-MSElemental analysis in biological samples generally is achieved using flame atomic absorption spectrometry (AAS) and graphite furnace AAS (GFAAS). Flame AAS is fast, easy-to-use, and economical, but insufficiently sensitive for assays such as Se in serum and Pb/Cd in whole blood. These measurements require use of the more sensitive GFAAS. Inductively coupled plasma-mass spectrometry (ICP-MS), despite its low detection limit capabilities and wide elemental range, has had relatively little impact to date on biomedical analysis because of the popularly held conception that it is complex to use and expensive. In recent years, the instrumentation has been simplified and purchase, running, and maintenance costs have fallen. As a result, clinicians are becoming more interested in ICP-MS, although the perception that it is still much more expensive than GFAAS remains. This article provides a comparison of the costs of ICP-MS and GFAAS for biomedical sample analysis and illustrates the performance of ICP-MS for..
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MS Detection of Waste in Public Swimming FacilitiesThere is often insufficient prevention to ensure safe swimming environments. Recreation water illness (RWI), most commonly in the form of digestional track illness as well as skin, ear, and respiratory infections, are often caused by water contamination from human waste. Stercobilin is a very stable and suitable chemical biomarker of human waste that has the potential to be used for waste monitoring in public swimming facilities. Using solid phase extraction (SPE) techniques paired with high-resolution mass spectrometry (HRMS), we have developed a robust method used for swimming pool water monitoring to create safer swimming environments.
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On-line and Off-line 2-D LC–ESI MS-MS Methods in Proteomic AnalysisOff-line 2-D LC–MS-MS represents a powerful alternative to on-line methodologies for protein identification from complex proteomes, improving the chromatographic resolution of digest peptide mixtures, even for low-abundance proteins. Here, the authors provide a detailed comparison of the two techniques.
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Advances in the Separation and Detection of As, Cr, and Se Species in Potable Waters Using HPLC Coupled with Dynamic Reaction Cell ICP-MSHere, the authors discuss a multielement method for the simultaneous determination of inorganic As, Cr, and Se species in potable waters using a HPLC system coupled to a dynamic reaction cell indusctively coupled plasma mass spectrometer.
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ICP-MS Interface Cones: Maintaining the Critical Interface between the Mass Spectrometer and the Plasma Discharge to Optimize Performance and Maximize Instrument ProductivityA detailed look at the most critical component of an ICP-MS instrument: the interface cones
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Reducing the Impact of Spectral Interferences on the Determination of Precious Metals in Complex Geological Matrices Using DRC ICP-MSThe potential for signal drift, matrix suppression, and spectral interference, in addition to demanding sample preparation, can make geological matrices some of the most difficult to analyze by conventional inductively coupled plasma-mass spectrometry.
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The Analysis of Food Substances by ICP-MSElemental analysis of food substances presents a challenge because of the wide variety of food types and range of concentrations that need to be analyzed. This article discusses the analysis of a variety of food matrices with a single digestion procedure and instrumental method.
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RoHS/WEEE Application of a Miniature X-Ray SpectrometerThe RoHS/WEEE directive requires the electronics industry to certify that products comply with maximum concentration amounts of particular elements and compounds (Cr VI, Pb, Cd, Hg, Br PBB/PBDE) by July 2006. Instrumentation must be developed to perform the certification.
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New Capabilities of High-Resolution Ultrasonic Spectroscopy: Titration AnalysisHigh-resolution ultrasonic spectroscopy titration analysis is a powerful new tool in research and analytical laboratory work for quantitative measurements of different processes and compounds. Here, the authors explore its potential.
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New Capabilities of High-Resolution Ultrasonic Spectroscopy: Titration AnalysisHigh-resolution ultrasonic spectroscopy titration analysis is a powerful new tool in research and analytical laboratory work for quantitative measurements of different processes and compounds. Here, the authors explore its potential.
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Molecular Spectroscopy Workbench Near-infrared Chemical Imaging and the PAT Initiative (PDF)NIR-CI adds a completely new dimension to conventional spectroscopy.
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2006 Salary Survey: Salary Changes and Job Satisfaction in the Spectroscopy CommunityThis year's survey of salaries and job attitudes reveals that the market seems stable, but many spectroscopists are feeling the pressure of the economy at work.
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Efficient Raman Lasing in Tapered Silicon WaveguidesThe authors review the operating principles of a silicon Raman laser and show that by introducing a longitudinal variation of the waveguide width in the cavity, the lasing efficiency can be increased significantly.
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Detection of g-Hydroxybutyrate and g-Butyrolactone by Ion Mobility Spectrometry (PDF)The authors discuss g-hydroxybutyrate (GHB), a drug of abuse that is not detected in the drug-detection mode or positive polarity of commercial ion mobility spectrometers, but can be detected by ion mobility spectrometry (IMS) instruments in negative mode.
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On-line and Off-line 2-D LC–ESI MS-MS Methods in Proteomic AnalysisOff-line 2-D LC–MS-MS represents a powerful alternative to on-line methodologies for protein identification from complex proteomes, improving the chromatographic resolution of digest peptide mixtures, even for low-abundance proteins. Here, the authors provide a detailed comparison of the two techniques.
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Raman Microscopy as a Valuable Tool for Failure Analysis (PDF)The authors discuss several sample types encountered in their laboratory for which Raman spectroscopy is the only reliable method of analysis. The technique is shown to be a routine and cost-effective tool for the industrial laboratory.
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Advances in the Separation and Detection of As, Cr, and Se Species in Potable Waters Using HPLC Coupled with Dynamic Reaction Cell ICP-MSHere, the authors discuss a multielement method for the simultaneous determination of inorganic As, Cr, and Se species in potable waters using a HPLC system coupled to a dynamic reaction cell indusctively coupled plasma mass spectrometer.
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Chemically Selective Imaging with Broadband CARS MicroscopySeptember 2006. The authors rapidly acquire complete vibrational spectra in the fingerprint region using a single femtosecond laser for broadband coherent anti-Stokes Raman scattering (CARS) microscopy to image spatially variant compositions of condensed-phase samples.
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Test of an In Vivo Method to Detect Chloroplast Division in Crop Plants, Part III: Statistical Proofs of Observation and General Utility of the Method (PDF)This article is the third installment in a series about a novel spectrofluorometric method that allow for in vivo observation of the division of chlorplast populations in leaves of Arabidopsis thalania.
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In-Line Process Analysis of Residual Moisture in a Fluid Bed Granulator-Dryer Using NIR Spectroscopy (PDF)The authors describe the in-line moisture measurement of a pharmaceutical granulation of lactose, microcrystalline cellulose, and crospovidone in a fluid bed granulator-dryer using top sprayed granulating liquid. A near-infrared (NIR) prediction model was developed for moisture on spectra collected during a calibration run. Subsequent granulations were analyzed for moisture content real-time throughout the granulation and drying process using the NIR process instrument.
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Criteria for High-Quality Raman MicroscopyFive key qualitative factors–speed, sensitivity, resolution, modularity and upgradeability, and combinability–contribute to the quality of confocal Raman imaging microscopes. Using application examples, this article introduces modern Raman imaging and correlative imaging techniques, and presents state-of-the-art practice examples from polymer research, pharmaceutics, low-dimensional materials research, and life sciences.
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Savitzky–Golay Smoothing and Differentiation Filter of Even Length: A Gram Polynomial ApproachIn various fields such as signal processing, imaging processing, analytical chemistry, and spectroscopic analysis, smoothing and differentiation is important and necessary. With a matrix approach, the Savitzky–Golay smoothing and differentiation filter was extended recently to even length. In this article, a more general approach is proposed for convenient computation.
Latest:
New Developments in Wavelength-Dispersive XRF and XRD for the Analysis of Foodstuffs and Pharmaceutical MaterialsSeptember 2006. The authors discuss the benefits of X-ray fluorescence (XRF) for the determination of elemental nutrients in foodstuffs and X-ray diffraction (XRD) for the measurement and characterization of different compounds used in the pharmaceuticals industry.
