October 14th 2024
A recent study used Raman spectroscopy to monitor cell culture processes.
Identification and Analysis of Medicinal Components in Rhubarb Roots Using Terahertz Spectroscopy
April 28th 2023Terahertz time-domain spectroscopy was used to identify and analyze the low-frequency vibrational modes of three free anthraquinones, revealing the vibrational contributions of different atoms and groups.
New DSIS Method Developed for Simultaneous Detection of Cadmium and Lead in Water Samples
April 27th 2023Researchers have developed a method for the simultaneous determination of cadmium and lead in water samples using microwave-induced plasma optical emission spectrometry with multiwalled carbon nanotubes pre-concentration and a discrete sample introduction system.
Standardizing Solutions to Enabling Platforming of Process Analytical Technology (PAT) Deployments
April 24th 2023Gary McGeorge, Scientific Director at Bristol-Myers Squibb, spoke to us of the benefits and challenges associated with establishment of consistent resolutions while facilitating the steps associated with the implementation of process analytical technology (PAT).
Investigating Protein Receptors and Other Biomolecules Using SERS and TERS
September 2nd 2021Zac Schultz of The Ohio State University and his team used tip-enhanced Raman spectroscopy (TERS) and surface-enhanced Raman spectroscopy (SERS) with gold nanostars to investigate chemical reactions involved in protein–ligand binding. He recently spoke with Spectroscopy about his findings.
Exploring Neurochemistry Using Raman Spectroscopy
September 2nd 2021Bhavya Sharma is the winner of the 2021 Emerging Leader in Molecular Spectroscopy Award. We recently interviewed her about her work conducting research to detect active and important biomolecules related to hormone regulation, neurological health, and disease diagnosis.
Developing Electrochemical and Optical Sensors to Measure Analytes in Physiological Samples
September 2nd 2021Mark Meyerhoff has been exploring chemical sensors for biomedical applications. Because of his work, Meyerhoff has been awarded the 2021 ANACHEM award. Meyerhoff spoke to us about his work, his career, and what being presented this award at this fall’s SciX event means to him.
High-Definition Fourier Transform Infrared Spectroscopic Imaging of the Tumor Microenvironment
September 2nd 2021Professor Rohit Bhargava and his team at the University of Illinois, where they have established the Cancer Center at Illinois, are advancing research in tumor microenvironments, using techniques such as high-definition Fourier transform infrared (HD-FT-IR) coupled with machine learning. We recently spoke to Bhargava about this work.
Investigating Lanthanide Deposition Patterns in Tissue Using LA-ICP-MS Imaging
September 1st 2021Uwe Karst of the University of Münster in Germany explains the use of laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) imaging to provide spatially resolved quantification of trace elements in biological samples.
Quantitative Methods for Multielemental Analysis in Low-Volume Biofluids
February 1st 2021In precious samples, effective methods for multielemental analysis could provide a deeper understanding of the essential role of elements as cofactors in biological and pathological processes. Tobias Konz of Nestlé Research explains.
New Spectroscopy-Based Approaches in Bioanalysis and Personalized Medicine
December 1st 2017Medical diagnostics is an exciting area of spectroscopy research, and one of the dreams is to develop spectroscopic tools that can be used for point-of-care diagnostics with a smartphone. Russ Algar, the 2017 Emerging Leader in Molecular Spectroscopy, is one of the scientists on that quest
High Spatial Resolution FT-IR Imaging of Biomedical Tissue Samples Using Existing Objectives
April 22nd 2015Fourier Transform Infrared (FTIR) imaging is a well-established analytical method for obtaining spectral and spatial information simultaneously in the micron-size domain. The technique has been applied across many different application areas, from polymer science to biomedical imaging. Over recent years, interest has increased in pushing the diffraction limited spatial resolution performance of FTIR imaging systems, primarily using synchrotron based systems.
Duncan Graham Named Recipient of Coblentz Society's 2012 Craver Award
February 22nd 2012The Coblentz Society and the Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) recently named Professor Duncan Graham of the University of Strathclyde (Glasgow, Scotland) as the recipient of the Coblentz Society?s 2012 Craver Award.
Mass Spectrometry and Glial Cells
April 20th 2009Using a new mass spectrometry technique and stem cells that can be made to produce either neurons or glial cells, a team of researchers at the Salk Institute for Biological Studies (La Jolla, California) identified a molecular signaling pathway that is required for the production of glial cells, yielding insight into the neurobiology of Down?s syndrome and several nervous system disorders characterized by too many glial cells.
In this article, the role of a triple-quadrupole mass spectrometer in performing in vitro studies of compound metabolic stability and identification of Phase I and II metabolites is demonstrated.
Influence of Na+ and K+ Concentration in solvents on Mass Spectra of Peptides in LC–ESI-MS
February 1st 2006The concentration dependent influence of Na+ and K+ions on mass spectra of peptides is shown with human gastrin as a model peptide. With electrospray ionization the doubly charged protonated molecule ion [M+2H]2+ is normally the preferred ionization product. However, trace amounts of alkali metal ions already form clusters (adducts) with the peptide molecule, such as [M+H+Na]2+, which become dominating at higher concentrations. With Na+/K+ concentrations below 0.1 mg/kg (ppm) only a few clusters appear, which allow the correct doubly charged molecule ion to be assigned for a subsequent MS–MS experiment. With concentrations of 10 ppm and higher the alkali clusters become the most abundant peaks in the spectrum, and the absolute sensitivity is decreased by a factor of 5–10. Experiments were performed with water and water–methanol mixtures with a known Na+/K+ +content.