Surface-enhanced Raman spectroscopy (SERS)

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Using SERS to Explore Cancer Cells with MTAP Deletions

January 5th 2024

A recent study from Spain used surface-enhanced Raman spectroscopy (SERS) to study cancer cells with methylthioadenosine phosphorylase (MTAP) deletions, shedding new insights into the metabolic interactions inside the tumor microenvironment that could influence cancer aggression.

Liver cancer. 3D illustration showing presence of tumor inside liver | Image Credit: © Dr_Microbe -
SERS Used to Detect Early-Stage Liver Cancer

January 3rd 2024

Messenger RNA or mRNA strand 3D rendering illustration with copy space. Genetics, science, medical research, genome replication concepts. | Image Credit: © Matthieu -
Revolutionizing Diagnostics: Machine Learning Unleashes the Power of Surface-Enhanced Raman Spectroscopy

November 21st 2023

titanium metal alloy, used in the industry, titanium is a transition metal that adds value to metal alloys because it is light and resistant | Image Credit: © RHJ -
Innovative Nanosheets Propel Advancements in Sensitive Surface-Enhanced Raman Spectroscopy

November 12th 2023

Pile of shining gold pieces seen from above. Top view macro image of sparkling gold dust for backgrounds and textures. Selective focus and shallow depth of field. | Image Credit: © Ole -
Novel SERS Sensor Array Based on Gold Nanorods and Nanostars Identifies Five Antioxidants

September 21st 2023

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Recording the Raman Spectrum of a Single Molecule

Recording the Raman Spectrum of a Single Molecule

September 2nd 2021

Analytical chemists are continually striving to advance techniques to make it possible to observe and measure matter and processes at smaller and smaller scales. Professor Vartkess Ara Apkarian and his team at the University of California, Irvine have made a significant breakthrough in this quest: They have recorded the Raman spectrum of a single azobenzene thiol molecule. The approach, which breaks common tenets about surface-enhanced Raman scattering/spectroscopy (SERS) and tip-enhanced Raman spectroscopy (TERS), involved imaging an isolated azobenzene thiol molecule on an atomically flat gold surface, then picking it up and recording its Raman spectrum using an electrochemically etched silver tip, in an ultrahigh vacuum cryogenic scanning tunneling microscope. For the resulting paper detailing the effort [1], Apkarian and his associates are the 2021 recipients of the William F. Meggers Award, given annually by the Society for Applied Spectroscopy to the authors of the outstanding paper appearing in the journal Applied Spectroscopy. We spoke to Apkarian about this research, and what being awarded this honor means to him and his team. This interview is part of an ongoing series with the winners of awards that are presented at the annual SciX conference. The award will be presented to Apkarian at this fall’s event, which will be held in person in Providence, Rhode Island, September 28–October 1.