Surface-enhanced Raman spectroscopy (SERS)

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DNA strand and Cancer Cell Oncology Research Concept 3D rendering | Image Credit: © catalin - stock.adobe.com

A recent study from Spain used surface-enhanced Raman spectroscopy (SERS) to study cancer cells with methylthioadenosine phosphorylase (MTAP) deletions, shedding new insights into the metabolic interactions inside the tumor microenvironment that could influence cancer aggression.

Messenger RNA or mRNA strand 3D rendering illustration with copy space. Genetics, science, medical research, genome replication concepts. | Image Credit: © Matthieu - stock.adobe.com

Duke University researchers, led by Joy Q. Li, revolutionize biomedical diagnostics with a multiplexed SERS-based nanosensor called inverse molecular sentinel (iMS) for micro-RNA detection, employing machine learning, particularly convolutional neural networks (CNN) and non-negative matrix factorization (NMF), to achieve higher accuracy in spectral unmixing, paving the way for more precise and efficient clinical diagnostics.

Portable Raman Spectrometer | Image Credit: © Forance - stock.adobe.com

There is a growing desire among spectroscopists for having instruments small enough to be taken to the sample, as opposed to bringing the sample to the instrument. The result is that Raman spectrometers are becoming more miniaturized. Because these instruments come at a lower cost and offer distinct advantages over traditional spectrometers, the expectation is that a rapid expansion of when these instruments are applied will come forthwith. We offer a preview of how future miniaturized Raman spectrometers might look.