SPEC PerkinElmer 10.13

Jerome Workman, Jr.

Jerome Workman, Jr.

Jerome Workman, Jr. is former Senior Technical Editor of LCGC. He is on the Editorial Advisory Board of Spectroscopy and is the current Assoc. Editorial Director. He is the co-host of the Analytically Speaking podcast and has published multiple reference text volumes, including the three-volume Academic Press Handbook of Organic Compounds, the five-volume The Concise Handbook of Analytical Spectroscopy, the 2nd edition of Practical Guide and Spectral Atlas for Interpretive Near-Infrared Spectroscopy, the 2nd edition of Chemometrics in Spectroscopy, and the 4th edition of The Handbook of Near-Infrared Analysis. He is the recipient of the 2020 NY/NJ SAS Gold Medal Award (with Howard L. Mark). Mark and Workman have written over 250 Statistics and Chemometrics columns for Spectroscopy. Direct correspondence to jworkman@mjhlifesciences.com

Articles by Jerome Workman, Jr.

Sparks near Reno Nevada – Site of 2026 SciX Conference ©   DTM Media  -chronicles-stock.adobe.com

Wednesday's program at SciX 2026 kept returning to one question: can spectroscopy perform outside the controlled laboratory? Speakers took surface-enhanced Raman scattering (SERS), laser-induced breakdown spectroscopy (LIBS), mid-infrared photonics, chemometrics, and fluorescence excitation–emission matrix (EEM) spectroscopy into clinics, food plants, reactor coolant loops, brine fields, and drinking water supplies.

NIR Spectroscopy of the Brain and Other Complex Analyses, ©   Navaporn  -chronicles-stock.adobe.com

Near-infrared spectroscopy has quietly stopped being a niche calibration exercise and started acting like an autonomous diagnostic partner, reading consciousness in an injured brain, steering a fermenter without a human hand, and hunting invisible plastic in a glass of water. The tool chemists once used to check moisture in grain is now fusing with artificial intelligence to make decisions no spectrometer could make alone.

FACSS 2026 Award Interviews ©  Erin -chronicles-stock.adobe.com

Eight FACSS award winners at SciX 2026, One LIBS trailblazer. Forty-eight questions. And not one of them is a softball. Award season in spectroscopy usually means polite applause, a plaque, and a photo. We're not completely interested only in the award sessions. The eight scientists honored at SciX 2026 in Sparks, Nevada, along with LIBS researcher Alessandro De Giacomo, are pushing Raman into operating rooms, flying LIBS on drones, reading chemistry off Mars, and tracing toxic metals downwind of industrial sites. Their work makes big claims. In the coming days, Spectroscopy will sit down with eight of these researchers and ask whether those claims hold up. The interviews that follow won't just celebrate. They'll press on the gaps between simulation and experiment, between the lab bench and the clinic, and between a clever paper and an instrument someone will actually buy and use.

Spectral Frontiers: Past the Diffraction Limit (FT-IR Spectroscopy)

Fourier-transform infrared (FT-IR) spectroscopy, long the workhorse of molecular fingerprinting, is being reinvented by photothermal detection schemes and quantum cascade laser (QCL) sources that push spatial resolution and analysis speed far beyond classical dispersive and interferometric limits. New instrumentation such as optical photothermal infrared (O-PTIR) microscopy and laser direct infrared (LDIR) chemical imaging is enabling sub-micron, label-free chemical mapping of biological, environmental, and pharmaceutical samples. This article reviews the latest FT-IR-adjacent technologies, recent patents, and research driving the field, featuring perspectives from the scientists and instrument developers advancing the technique.

Infrared Reimagined: How FT-IR Spectroscopy Learned to Read Molecules, ©  Luis Eduardo  -chronicles-stock.adobe.com

FT-IR spectroscopy, long treated as a mature bench technique for confirming a carbonyl stretch or fingerprinting a polymer, has quietly become one of chemistry’s most versatile discovery engines: it now infers molecular structure straight from a spectrum without a reference library, resolves chemistry tens of nanometers wide, and screens a fingerstick of blood for disease in minutes. The last five years of published research show FT-IR moving from a confirmatory tool into a predictive, autonomous, and field-ready analytical platform.

This interactive e-book celebrates National Forensic Science Week by highlighting the vital role of spectroscopy in modern criminal investigations and emphasizing how technological innovation is making forensic analysis faster, safer, and more reliable for courtroom testimony.

Scientist With Portable Spectrometer in Natural Field Setting ©  By Tika -chronicles-stock.adobe.com

The bulky bench-top NIR spectrometer is quietly being dismantled and rebuilt as a wafer-scale photonic chip, a self-calibrating algorithm, and a sensor small enough to ride in a shirt pocket. What once demanded a grating, a moving mirror, and a climate-controlled lab now fits inside a handheld module, a bioreactor probe, or a drone payload, and it increasingly figures out what it is looking at on its own.

Jay P. Kitt, a University of Utah research assistant professor who has spent a decade extending confocal Raman microscopy from phospholipid membranes to nucleic acids and peptide-membrane interactions, is the recipient of Spectroscopy's 2026 Emerging Leader in Molecular Spectroscopy Award.

John Philip Walters (1)

John Philip Walters, Ph.D. (1938-2026), was an analytical chemist who spent 17 years researching the physics of spark-discharge emission spectroscopy at the University of Wisconsin-Madison before moving to St. Olaf College in 1982, where he became best known for pioneering a role-playing undergraduate laboratory model that had students take on professional roles to mirror real analytical-chemistry work. His 1991 three-part series on the approach in Analytical Chemistry earned him the ACS Division of Analytical Chemistry's J. Calvin Giddings Award in 1993, and he continued extending his understand-the-system teaching philosophy into computer-controlled instrumentation well into his later career.

Artist’s conception of a futuristic laser-based instrument ©  MD AL AMIN-chronicles-stock.adobe.com

Raman spectroscopy is shedding its bulky, benchtop reputation as chip-scale spectrometers, tip-enhanced probes, and AI-native detectors push the technique into pockets, production lines, and single molecules. The result is an instrument category being rebuilt from the optics up, faster, smaller, deeper, and smarter than the Raman systems of even five years ago.

Peter R. Griffiths, a pioneering figure in Fourier transform infrared (FT-IR) spectroscopy who authored or coauthored more than 300 scientific papers and numerous books over five decades, died August 29, 2026, at age 84. This tribute traces his career from Oxford and Digilab through Ohio University and the University of Idaho, his landmark books and the Handbook of Vibrational Spectroscopy, and his many honors, including the 2023 Ellis R. Lippincott Award and 2024 Optica Fellowship.

Atomic spectroscopy has quietly moved past splitting light and counting ions toward instruments that track a single nanoparticle, fuse a laser pulse with an isotope-ratio mass spectrometer, and correct their own interferences with artificial intelligence in real time. The result is a new class of ICP-MS, LIBS, and X-ray fluorescence (XRF) platforms that are turning what used to be a benchtop-only science into field-ready, self-optimizing analytical intelligence.

This is Chemometrics in Spectroscopy Column Number 251. In Column Number 250, we left you with a puzzle. We had just shown that a little-known piece of two-hundred-year-old mathematics, Lagrange's method of undetermined multipliers, could force an MLR calibration to ignore one particular, carefully chosen direction of repack-induced spectral change. It worked, but it only handled one direction at a time, and we admitted we had no idea whether the trick could be extended to PCR or PLS. That bothered us. So in this installment we go looking for the more general version of the idea, and we find it sitting in some very good recent work by Neal Gallagher and Nathanial Watson on what they call clutter suppression (a framework built for a completely different problem, target detection in hyperspectral imaging, that turns out to fit ours almost perfectly). Put the two together and you get an algorithm that whitens the calibration spectra with a clutter covariance matrix estimated from repack replicates, then hands the whitened data to the same Lagrangian machine we built last time. The payoff: the correction now generalizes to several, non-proportional directions of diffuse-reflection variability at once, and, because it is just a preprocessing step, it works ahead of PLS and PCR as well as MLR, which finally answers the question we could not answer before. This approach may very well be an answer to repack variation in repeated solid or slurry sample measurements using diffuse reflection. In this column we change gears with our writing tone and format by taking a "chemometry" approach, rather than a strict tutorial one. In future columns we hope to "unpack" this information in our more typical extended and tutorial manner. Let's explore solving this repack variation problem together.