July/August 2025

Thomas Mayerhöfer and Jürgen Popp

In this tutorial, Thomas G. Mayerhöfer and Jürgen Popp introduce complex-valued chemometrics as a more physically grounded alternative to traditional intensity-based spectroscopy measurement methods. By incorporating both the real and imaginary parts of the complex refractive index of a sample, this approach preserves phase information and improves linearity with sample analyte concentration. The result is more robust and interpretable multivariate models, especially in systems affected by nonlinear effects or strong solvent and analyte interactions.

Yukihiro Ozaki

Tip-enhanced Raman Scattering Using a Chemically-Modified Tip

Published: | Updated:

In this tutorial article, Yukihiro Ozaki explores the recent advancements and broadening applications of tip-enhanced Raman scattering (TERS), a cutting-edge technique that integrates scanning probe microscopy (SPM) with surface-enhanced Raman scattering (SERS).