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At SciX, Zac Schultz of The Ohio State University sat down with Spectroscopy to discuss his work characterizing molecular interactions with localization microscopy techniques, as well as give his thoughts about how spectrally resolved surface-enhanced Raman spectroscopy (SERS) imaging will impact in vitro cell imaging and other application areas.

In this interview segment, Prashant Jain of the University of Illinois Urbana-Champaign discusses the unique reaction pathways observed in light-driven chemistry on nanoparticles, particularly in CO2 reduction, and the insights gained into the quantum mechanical mechanisms of these reactions.

In this interview segment, Steven Bell, a professor of physical chemistry at Queen's University Belfast, provides an overview of his talk, and he also outlines what attendees can look forward to at this technical session, highlighting the list of speakers and their research interests.

In this video clip, Fay Nicolson, who is a Research Fellow at the Dana-Farber Cancer Institute and Harvard Medical School, highlights an oral session she is chairing tomorrow that will feature talks about the use of spectroscopy in disease management.

Unsolved Problems in Spectroscopy - Part 9

This tutorial examines the development of universal spectral libraries, reviewing standardization efforts, mathematical frameworks, and practical examples across multiple spectroscopies, while emphasizing metadata harmonization, FAIR principles, and the emerging role of AI in building interoperable, machine-readable repositories. This remains an unsolved problem in spectroscopy.

Ian Ciesniewski, Technical Director at Mettler Toledo.

As part of our coverage of Analytica USA, Spectroscopy sat down with Ian Ciesniewski, technical director at Mettler Toledo, to discuss the latest changes made to the United States Pharmacopeia (USP) Chapters 41 and 1251. In this interview segment, Ciesniewski discusses how the recent changes to these two chapters will impact organizations.

3I/ATLAS image NASA/James Webb Space Telescope (JWST), August 6, 2025. Available at nasa,gov

The interstellar object 3I/ATLAS, discovered in July, has captivated astronomers with its unusual characteristics. While some scientists attribute its behaviors to natural cometary processes, others propose more speculative theories, including the possibility of it being an artificial probe. This article examines both mainstream and speculative interpretations of 3I/ATLAS's anomalous features. Other news articles this week will look specifically at the spectroscopic results of telescopes recently analyzing this mysterious object.

Unsolved Problems in Spectroscopy - Part 8

This tutorial explores the challenges posed by nonlinearities in spectroscopic calibration models, including physical origins, detection strategies, and correction approaches. Linear regression methods such as partial least squares (PLS) dominate chemometrics, but real-world data often violate linear assumptions due to Beer–Lambert law deviations, scattering, and instrumental artifacts. We examine extensions beyond linearity, including polynomial regression, kernel partial least squares (K-PLS), Gaussian process regression (GPR), and artificial neural networks (ANNs). Equations are provided in full matrix notation for clarity. Practical applications across near-infrared (NIR), mid-infrared (MIR), Raman, and atomic spectroscopies are discussed, and future research directions are outlined with emphasis on hybrid models that integrate physical and statistical knowledge.

Fingerstick bead of blood for traditional invasive glucose testing © ddukang-chronicles-stock.adobe.com

Despite decades of major monetary investment for applied research in multiple spectroscopic sensing technologies, achieving an accurate, portable, and painless noninvasive glucose monitor remains a major unmet goal in diabetes care. This goal is extremely difficult due to persistent challenges with sensitivity, analyte specificity, accuracy, calibration stability, and biological interference.