Mass Spectrometry

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Synthesizing Synthetic Oligonucleotides: An Interview with the CEO of Oligo Factory

February 6th 2024

LCGC and Spectroscopy Editor Patrick Lavery spoke with Oligo Factory CEO Chris Boggess about the company’s recently attained compliance with Good Manufacturing Practice (GMP) International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Expert Working Group (Q7) guidance and its distinction from Research Use Only (RUO) and International Organization for Standardization (ISO) 13485 designations.

Potassium. Kalium. Alkali metals. Chemical Element of Mendeleev's Periodic Table. Potassium in square cube creative concept. | Image Credit: © Aleksander -
Potassium Isotopic Composition in Plants Analyzed Using MC-ICP-MS

December 12th 2023

Diatoms, algae under microscopic view, phytoplankton, fossils, silica, golden yellow algae | Image Credit: © elif -
Detecting Cadmium in Marine Phytoplankton Using Single-Cell Inductively Coupled Plasma Mass Spectrometry

December 6th 2023

Laser beam light effect | Image Credit: © donatas1205 -
New Laser Techniques Unlock Deuterium Release from Aluminum Layers

November 24th 2023

Holistic medicine approach. Healthy food eating, dietary supplements, healing herbs and flowers. Turmeric, dried lavender, spirulina powder in wooden bowls, fresh berries, omega acid capsules | Image Credit: © jchizhe -
More Than Just Acronyms at EAS 2023

November 14th 2023


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Gas Chromatography–Mass Spectrometry (GC–MS) with Cold Electron Ionization (EI): Bridging the Gap Between GC–MS and LC–MS

November 9th 2020

Gas chromatography–mass spectrometry (GC–MS) with cold electron ionization (EI) is based on interfacing the GC and MS instruments with supersonic molecular beams (SMB) along with electron ionization of vibrationally cold sample compounds in SMB in a fly-through ion source (hence the name cold EI). GC–MS with cold EI improves all the central performance aspects of GC–MS. These aspects include enhanced molecular ions, improved sample identification, an extended range of compounds amenable for analysis, uniform response to all analytes, faster analysis, greater selectivity, and lower detection limits. In GC–MS with cold EI, the GC elution temperatures can be significantly lowered by reducing the column length and increasing the carrier gas flow rate. Furthermore, the injector temperature can be reduced using a high column flow rate, and sample degradation at the cold EI fly-through ion source is eliminated. Thus, a greater range of thermally labile and low volatility compounds can be analyzed. The extension of the range of compounds and applications amenable for analysis is the most important benefit of cold EI that bridges the gap with LC–MS. Several examples of GC–MS with cold EI applications are discussed including cannabinoids analysis, synthetic organic compounds analysis, and lipids in blood analysis for medical diagnostics.