Mass Spectrometry

The authors discuss improvements in sample preparation for ADME/pharmacokinetic studies of therapeutic oligonucleotides.

In this article, the authors review the capabilities and challenges of deploying mass spectrometry (MS) to homeland security screening requirements.

This article presents an efficient analytical workflow for protein characterization using LC–MS.

The authors continue their discussion of the role of the analysis of fragment ions in the interpretation of an analyte's mass spectrum.

In this article, the authors discuss the advantages of using a microbore UHPLC system coupled with a tandem mass spectrometer for the quantitation of in vivo pharmacokinetic samples.

The authors discuss a noninvasive method for determining early indications of the rejection of a kidney transplant.

The 57th ASMS Conference on Mass Spectrometry was held at the Pennsylvania Convention Center, 1101 Arch Street, Philadelphia, Pennsylvania, from May 31 through June 4, 2009.

The author discusses the use of high-performance mass spectrometry for small molecule and protein applications.

The authors discuss analytical methods for lipidomics.

A structured, general purpose approach to method development for bioanalytical hydrophilic interaction chromatography–tandem mass spectrometry (HILIC–MS-MS) applications is described.

The authors discuss the use of high-resolution LC-MS to analyze complex samples in regulated environments such as food and animal-feed analysis.

The authors discuss the use of GC-MS in drug doping testing.

The authors discuss the use of electron ionization to determine a compound's structure.

Current Trends in Mass Spectrometry Goes Global

An oft-overlooked segment of the mass spectrometry market is time-of-flight LC–MS. Although LC-TOF does not possess the capabilities of more expensive mass spectrometry techniques, it fills an important price-to-performance segment of the market. The trickling down of technology and heavy competition are contributing to a strong market outlook for the area.

In this article, methods developed for rapid, automated detection of CWAs and TICs using a low thermal mass capillary gas chromatograph coupled to a toroidal ion trap mass spectrometer (TMS) are presented.

This article discusses the analysis of a wide range of CWAs at current exposure limits and describes a number of recent beneficial developments in TD and associated analytical technologies for the identification and quantification of CWAs at these levels.

The authors demonstrate the capacity to separate petroleum-derived molecules having the same nominal mass in the mobility dimension using IM-MS spectrometry.

This article describes trends of using LC-MS-MS for multicompound analysis of food and environmental contaminants.

The authors discuss the use of electron transfer dissociation as a reliable tool in proteomic research, especially in conjunction with a linear ion trap, for sequence analysis of post-translationally modified and highly basic peptides.

This article describes the use of a microfluidic chip system, paired with a simple, automated interface to a wide range of mass spectrometers for both protein and small molecule applications.

The authors present a novel method for analyzing and characterizing complex proteomic samples using multidimensional liquid chromatography with an emphasis on the reproducibility of results generated in different laboratories.

The authors discuss the use of reversed-phase LC-MS for oligonucleotide characterization.

This article discusses the potential use and application of comprehensive multidimensional gas chromatography-time-of-flight mass spectrometry in forensic toxicology analysis for illicit drugs in urine without sample derivatization.

Mass spectrometry (MS) is a broadly used analytical technique that is often combined with some form of chromatography to provide a second dimension of separation. However, vendors recently have begun incorporating ion mobility separation (IMS) into high-end LC–MS instruments, thus providing an additional level of ion separation.

In the second installment of this tutorial, the authors explain the instrumentation for measuring naturally occurring stable isotopes, specifically the magnetic sector mass spectrometer.

Columnist Ken Busch discusses the lack of a formal ethics training program for physical scientists and the need for some type of self-regulation within the field.

The authors discuss the use of electron-capture dissociation coupled with a linear ion trap time-of-flight mass spectrometer to investigate the structure of human transferrin.

At a symposium attended almost exclusively by practitioners of chromatography, the one thing they all wanted more of was mass spectrometry information.

The authors discuss the challenges presented by the many new applications of mass spectrometry.