Mass Spectrometry

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Team of Medical Research Scientists Collectively Working on a New Generation Experimental Drug Treatment. | Image Credit: © Elchin Abilov -
Evolving Role of Mass Spectrometry in Pharmaceutical Analysis Highlighted in New Review

June 25th 2024

A recent review article explored the recent advancements in mass spectrometry (MS) and how it is being applied in pharmaceutical analysis.

Gochujang, Korean red pepper paste. Generated with AI. | Image Credit: © Oleksandr -
Using ICP-OES and Mass Spectrometry to Determine the Geographical Origin of Chinese and Korean Red Pepper Paste

June 10th 2024

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Fluorescence-Based Chemosensor Developed for Analyzing Chromium Ions

May 23rd 2024

baggage inspection system, security and safety concept | Image Credit: © Mihail -
Mass Spectrometry and Infrared Spectroscopy to Improve Non-Contact Screening Methods at Airports

May 22nd 2024

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New Antigen-Bonding Fragment System Developed for Autoantibodies

May 20th 2024

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Gas Chromatography–Mass Spectrometry (GC–MS) with Cold Electron Ionization (EI): Bridging the Gap Between GC–MS and LC–MS

November 9th 2020

Gas chromatography–mass spectrometry (GC–MS) with cold electron ionization (EI) is based on interfacing the GC and MS instruments with supersonic molecular beams (SMB) along with electron ionization of vibrationally cold sample compounds in SMB in a fly-through ion source (hence the name cold EI). GC–MS with cold EI improves all the central performance aspects of GC–MS. These aspects include enhanced molecular ions, improved sample identification, an extended range of compounds amenable for analysis, uniform response to all analytes, faster analysis, greater selectivity, and lower detection limits. In GC–MS with cold EI, the GC elution temperatures can be significantly lowered by reducing the column length and increasing the carrier gas flow rate. Furthermore, the injector temperature can be reduced using a high column flow rate, and sample degradation at the cold EI fly-through ion source is eliminated. Thus, a greater range of thermally labile and low volatility compounds can be analyzed. The extension of the range of compounds and applications amenable for analysis is the most important benefit of cold EI that bridges the gap with LC–MS. Several examples of GC–MS with cold EI applications are discussed including cannabinoids analysis, synthetic organic compounds analysis, and lipids in blood analysis for medical diagnostics.