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News|Webcasts|December 20, 2024
Advanced Analytical Methods for Oligonucleotide ID Testing in Pharmaceuticals QC (Jan)
Author(s)Agilent Technologies, Inc.
Webinar Date/Time: Option 1: Wednesday, January 15, 2025 at 12pm BST | 1pm CET Option 2: Wednesday, January 15, 2025 at 11am PST | 2pm EST | 7pm GMT Option 3: Thursday, January 16, 2025 at 9pm IST | 12pm SGT | 1pm JST | 3pm AEDT
After a short introduction to oligonucleotides, this webinar will focus on the sequence-specific method and provide a deep dive into the UV-spectrometric determination of the oligonucleotide melting temperature (Tm) using the Agilent Cary 3500 UV-Vis.
Register Free:
Event Overview:
This webinar will discuss the adverse impact of particulate matter and aggregates for immunogenicity and the need to improve the characterization of submicron aggregates/particles in biopharmaceuticals. Optical Photothermal Infrared (O-PTIR) technology will be reviewed. The benefits of O-PTIR to perform nondestructive, simultaneous infrared (IR)/Raman measurements with submicron spatial resolution on particulate matter and aggregates in biopharmaceutical formulations (IV infusion in-use studies, stability and degradation studies) will be demonstrated.
Key Learning Objectives:
- Learn the impact of particles and aggregates in immunogenicity and toxicity.
- Understand how combining submicron IR and Raman microspectroscopy overcomes the limitations of traditional vibrational spectroscopy.
- Learn how O-PTIR microspectroscopy greatly improves knowledge and understanding of particles and aggregates in biopharmaceuticals.
Who Should Attend:
- Particle analysis/biopharmaceutical development scientists and engineers
- PAT and manufacturing engineers and scientists
- Regulatory compliance and quality operations scientific personnel
Speaker:
Alexandra H. Heussner, PhD
Laboratory Manager, Analytical Science Laboratory
Vetter Pharma
Alexandra H. Heussner, PhD, is an accomplished interdisciplinary scientist and laboratory manager within the Development Service of Vetter Pharma in Ravensburg, Germany. She is an acknowledged specialist in analytical procedure development and innovation and is a highly quotable author of numerous articles. Heussner’s field of scientific expertise includes bioanalytical technologies and chemical analyses. She frequently provides new solutions for complex challenges in a CDMO environment with a huge variety of sterile products. Examples include monitoring hydrogen peroxide in sanitization processes, the product-specific determination of residual moisture in lyophilization process development, and new testing methods for container closure integrity. Heussner received her PhD in applied sciences from the University of Sunderland in the United Kingdom and after many years in academic research, she joined Vetter Pharma in 2016. She is currently involved in implementing, developing, and validating analytical procedures and instruments with her team in the Analytical Science Laboratory.
Register Free:
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