Case Studies in the Application of Raman Microscopy (PDF)

Researchers from Ca’ Foscari University of Venice and the University of Padua have uncovered the earliest direct evidence of Upper Palaeolithic humans deliberately processing the non-edible plant Isatis tinctoria, revealing complex behaviors involving medicinal or dye-related plant use over 32,000 years ago.

An interview with Paul Pudney, a winner of the William F. Meggers Award.

Researchers have developed an analytical method combining remote near-infrared and Raman spectroscopy with machine learning to noninvasively map moisture and salt damage in historic buildings, offering critical insight into ongoing structural deterioration.

An interview with Charles Wilkins, the winner of the 2013 American Chemical Society Division of Analytical Chemistry Award in Chemical Instrumentation, sponsored by the Dow Chemical Company.

In this tutorial article, Yukihiro Ozaki explores the recent advancements and broadening applications of tip-enhanced Raman scattering (TERS), a cutting-edge technique that integrates scanning probe microscopy (SPM) with surface-enhanced Raman scattering (SERS). TERS enables highly localized chemical analysis at the nano- to subnano-scale, achieving spatial resolution well beyond the diffraction limit of light. Ozaki highlights the versatility of TERS in various experimental environments—ranging from ambient air to ultrahigh vacuum and electrochemical systems—and its powerful utility in fields such as single-molecule detection, biomolecular mechanism studies, nanomaterial characterization, and high-resolution imaging.

Raman spectroscopy emerges as a powerful tool for quantifying adenine in nucleic acid therapeutics, enhancing analytical efficiency and quality assessment.