Raman Spectroscopy

A new comparative study shows that scientific CMOS (sCMOS) cameras could rival traditional CCD detectors in certain Raman CARS spectroscopy applications, offering faster readout and dynamic range despite slightly higher noise levels.

Researchers from Guangdong Polytechnic Normal University highlight how combining Raman spectroscopy with machine learning enables rapid, non-destructive, and highly accurate analysis of fruit quality, offering transformative potential for food safety and agricultural diagnostics.

DOGE-related federal funding cuts have sharply reduced salaries, lab budgets, and graduate support in academia. Researchers view the politically driven shifts in priorities as part of recurring systemic issues in U.S. science funding during administrative transitions. The impact on Federal laboratories has varied, with some seeing immediate effects and others experiencing more gradual effects. In general, there is rising uncertainty over future appropriations. Sustainable recovery may require structural reforms, leaner administration, and stronger industry-academia collaboration. New commentary underscores similar challenges, noting scaled-back graduate admissions, spending freezes, and a pervasive sense of overwhelming stress among faculty, students, and staff. This article addresses these issues for the analytical chemistry community.

Researchers at Heilongjiang University have developed a rapid and accurate method for detecting sweeteners in food using Raman spectroscopy combined with a Random Forest machine learning algorithm, offering a powerful tool for improving food safety.

A new review highlights how vibrational spectroscopy techniques like FTIR, NIR, and Raman offer rapid, non-destructive tools for accurately analyzing plant-based protein content and structure.

Researchers from Shanghai Jiao Tong University are harnessing artificial intelligence to elevate surface-enhanced Raman spectroscopy (SERS) for highly sensitive, multiplexed biomedical analysis, enabling faster diagnostics, imaging, and personalized treatments.

A recent study presented a dual-method approach combining confocal micro-Raman spectroscopy and Nile Red-assisted fluorescence microscopy to enhance the accuracy and throughput of microplastics detection in environmental samples.

A new review led by researchers from MIT and Oak Ridge National Laboratory outlines how artificial intelligence (AI) is transforming the study of molecular vibrations and phonons, making spectroscopic analysis faster, more accurate, and more accessible.

Researchers from Chinese universities have developed an AI-powered platform that combines near-infrared (NIR) and Raman spectroscopy for real-time monitoring and control of antibiotic production, boosting efficiency by over 30%.

Researchers from Cranfield University and partners from industry demonstrated the feasibility of using advanced, non-destructive imaging techniques to analyze and standardize organo-mineral fertilizers.

A team of researchers from Spanish institutions has found that polystyrene used in healthcare packaging shows strong resistance to UVC sterilization, with minimal chemical degradation detected using FT-IR and Raman spectroscopy.

A multinational research team explores Raman spectroscopy's expanding role in medicine and microbiology, revealing its powerful potential in diagnostics, drug analysis, and microbial classification.

Researchers at Georgia College and Purdue University have developed a fast, low-cost method using Raman and UV–visible spectroscopy combined with chemometric modeling to accurately screen and quantify active ingredients in over-the-counter oral syrups, helping to fight counterfeit medications.

Researchers from the Institute of Agrifood Research and Technology (IRTA) in Catalunya, Spain used fluorescence and Raman spectroscopy to explore complex tissue changes behind wooden breast myopathy in chickens.

HÜBNER Photonics, manufacturer of high-performance lasers for advanced imaging, detection and analysis, proudly announces the addition of a new wavelength on the Cobolt 05-01 Series of single frequency lasers.

In an announcement on June 12, Rigaku Analytical Devices, which is a division of Rigaku Holdings Corporation headquartered in Akishima, Tokyo, announced the launch of its Icon series of 1064-nm Raman analyzers, its fourth-generation of the instrument.

Researchers from Ca’ Foscari University of Venice and the University of Padua have uncovered the earliest direct evidence of Upper Palaeolithic humans deliberately processing the non-edible plant Isatis tinctoria, revealing complex behaviors involving medicinal or dye-related plant use over 32,000 years ago.

Top articles published this week include an interview about aromatic–metal interactions, a tutorial article about the recent advancements in tip-enhanced Raman spectroscopy (TERS), and a news article about using shortwave and near-infrared (SWIR/NIR) spectral imaging in cultural heritage applications.

Researchers have developed an analytical method combining remote near-infrared and Raman spectroscopy with machine learning to noninvasively map moisture and salt damage in historic buildings, offering critical insight into ongoing structural deterioration.

Researchers in Thailand have developed a cost-effective standoff Raman spectroscopy system using a night-vision intensified spectrometer and digital correction algorithms. The system reliably detects chemical compounds at distances up to 60 meters with high spectral resolution.

In this tutorial article, Yukihiro Ozaki explores the recent advancements and broadening applications of tip-enhanced Raman scattering (TERS), a cutting-edge technique that integrates scanning probe microscopy (SPM) with surface-enhanced Raman scattering (SERS). TERS enables highly localized chemical analysis at the nano- to subnano-scale, achieving spatial resolution well beyond the diffraction limit of light. Ozaki highlights the versatility of TERS in various experimental environments—ranging from ambient air to ultrahigh vacuum and electrochemical systems—and its powerful utility in fields such as single-molecule detection, biomolecular mechanism studies, nanomaterial characterization, and high-resolution imaging.

Raman spectroscopy emerges as a powerful tool for quantifying adenine in nucleic acid therapeutics, enhancing analytical efficiency and quality assessment.

A recent review in the Journal of Pharmaceutical Analysis highlights how AI, particularly deep learning, is revolutionizing Raman spectroscopy by enhancing its accuracy, efficiency, and applications in drug development, quality control, and clinical diagnostics.

A recent study explored new rapid screening alternatives to traditional methods for detecting pork adulteration in meatballs, aiding halal food authentication efforts.

In this Icons of Spectroscopy article, Executive Editor Jerome Workman Jr. delves into the life and impact of Bruce Kowalski, an analytical chemist whose major contributions to chemometrics helped establish the field of applying advanced quantitative and qualitative mathematics to extract meaningful chemical information from complex datasets. Kowalski’s visionary approach to chemical data analysis, education, and software development has transformed the landscape of modern analytical chemistry for academia and industry.

Spanish scientists have combined Raman imaging with powerful chemometric tools to identify and map organic molecules in a Martian meteorite, offering key insights for future Mars sample return missions and the search for past life on the Red Planet.

A team of scientists in Poland has unveiled the first detailed structural and magnetic analysis of the Ribbeck meteorite, a recently recovered space rock classified as an aubrite. Using Raman spectroscopy, X-ray diffraction, and advanced magnetic testing, researchers revealed the meteorite's unique mineralogy and its connection to deep space conditions.

Researchers in Rome used advanced spectroscopic techniques to probe the mineralogy of the CM2 carbonaceous chondrite NWA 12184. This revealed the effects of space weathering and provided insights into C-type asteroid evolution.

Researchers at McGill University have developed a fast, eco-friendly method using portable Raman spectroscopy and deep learning to accurately assess the antioxidant content of maple syrup on-site.