Raman Spectroscopy

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SARS-CoV-2, 3d rendering of spike protein (blue) ©  Naeblys - stock.adobe.com

Researchers at Budapest University of Technology and Economics have developed a novel method for real-time monitoring of the protein purification process using Raman and near-infrared (NIR) spectroscopy. Their study compares the effectiveness of these two spectroscopic techniques in tracking the removal of imidazole, a process-related impurity, during the purification of the SARS-CoV-2 spike protein's receptor-binding domain (RBD).

Spaceman and planet, human in space concept | Image Credit: © Sergey Nivens - stock.adobe.com.

A trip to the Lyndon B. Johnson Space Center served as a reminder of the importance of space exploration and the key role spectroscopy plays in this industry.

The Search for signs of extraterrestrial life in space ©  Aleksandra - stock.adobe.com

Researchers from Humboldt-Universität zu Berlin and the German Aerospace Center (DLR) have developed a cutting-edge fiber-dispersive Raman spectrometer (FDRS) capable of detecting low-density biological matter in space. By combining a single-photon detector with a dispersive optical fiber element, the team achieved a breakthrough in in-situ Raman spectroscopy, promising unprecedented sensitivity and reliability in the search for extraterrestrial rudimentary life.

3D biological imaging of stem cells  © Prasanth - stock.adobe.com

Recent advancements in highly-multiplexed Raman imaging are set to revolutionize 3D spatial biology, offering unprecedented insights into complex biological systems. This new technology, highlighted in the Royal Society of Chemistry journal Chemical Communications, was reported by researchers from Shanghai Medical College, shows promise for enhancing our understanding of physiological functions and disease progression.

Using Raman for liquid brain biopsies © Leo - stock.adobe.com

Recent research highlights the potential of liquid biopsy combined with Raman spectroscopy (RS) in diagnosing brain disorders. These innovative techniques offer non-invasive, precise, and continuous monitoring capabilities, presenting a promising future for early detection and intervention in conditions such as neurodegenerative diseases (NDs) and traumatic brain injury (TBI).