Raman Spectroscopy

Latest News


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In the three decades since its discovery, surface-enhanced Raman scattering (SERS) has been used in numerous applications to increase signal intensity in Raman scattering experiments. The current study provides insight into the more practical aspects of enhanced Raman sampling for laboratory users. We describe how the signal enhancement from a surface-enhanced resonant Raman scattering (SERRS) process improves the ability to discriminate between ink samples using principal component clustering.

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Temperature measurements can be made using spectral features such as the position, linewidth, and intensity of the Raman signal associated with specific optical phonon modes. Each of these spectral characteristics offers particular advantages, depending on the type of device and operational considerations.

How can you navigate the maze of choices for detecting molecular vibrations with mid-infrared (IR), near IR (NIR), and visible (Raman)? Understanding what is being measured, how it is measured, and the advantages and disadvantages of each technique, will help.

Raman spectroscopy can be used to measure the vibrational spectra of both organic and inorganic materials.

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In recent years, the spectroscopy community has observed rapid development of Raman instrumentation and its usefulness in a variety of applications. Routine Raman analysis with 785 nm excitation has served well for the great majority of industrial applications and has become the most favored instrument configuration.

Little Points of Light

Virtually everything we know about stars is based on spectroscopy, including what we know about magnitude, red shift, and why the night sky is dark.

Multiphoton Spectroscopy

This month's column discusses the various multiphoton spectroscopy techniques and the lasers required for each approach.

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For the characterization of the properties of a sample with Raman spectroscopy, an ultrasensitive confocal Raman microscope allows the acquisition of a Raman image stack revealing 3-D information on the distribution of the chemical compounds.

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The motivation for the development of an instrument for transmission Raman measurements is described. The basic instrumentation and the first results from a commercial system are provided. Transmission Raman spectroscopy (TRS) performance is compared to and contrasted with that of a confocal Raman microscope.

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Today's Raman spectrometers are more capable than ever before. The seeds of innovation in filter, laser, and CCD technology have produced a crop of instruments that are fast, sensitive, and robust. This is good news because scientists are constantly bombarded with challenging problems that require the top performance from their instruments.

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Surface-enhanced Raman spectroscopy (SERS) has been studied extensively over the last few decades with many advances in preparation of SERS substrates and coatings. While the bulk of the research in SERS substrate preparation has been devoted to pushing detection limits to higher sensitivity for measurement of single samples, the application of SERS to high-throughput analysis has been largely ignored. In this article, we present the use of commercially available SERS-coated microtiter plates in a dedicated Raman microtiter plate reader, enabling high-throughput trace analysis measurements. This article also describes the SERS substrate, the high-throughput plate reader, and preliminary results from samples representing trace analysis of explosives, nerve agents, pharmaceuticals, and biological compounds.