Application Notes: General

This study demonstrates the through-opaque-container analysis capability of the Agilent Vaya handheld Raman spectrometer by performing measurements on a range of common excipients and active ingredients within blue barrels. Spatially offset Raman spectroscopy (SORS) is the unique Agilent technology that is the basis of the unique Vaya container subtraction algorithm. This technology can optimize the spectra to provide the clearest signature of contents with the minimum amount of container interference. Verification of raw materials directly through plastic barrels provides efficient raw material identification (RMID) workflows in the warehouse without the need for specialized personnel or controlled sampling environments.

Handheld Raman spectrometers can distinguish raw materials through transparent and opaque packaging containers. This application note demonstrates the use of the handheld Agilent Vaya Raman raw material identity verification system based on spatially offset Raman spectroscopy (SORS) for chemical ID verification and testing of mRNA lipid nanoparticle (LNP) components through transparent glass and white opaque polyethylene containers.

Over 85% of scientific organizations have incorporated environmental sustainability into their long term goals and commitments. Agilent helps scientists reach their sustainability goals without compromising results or productivity, with products developed with the environment in mind. The Accountability, Consistency, and Transparency Label (ACT label) helps to communicate the environmental impact of manufacturing, operation, and disposal of scientific products and packaging, helping scientists make green equipment decisions. Agilent Vaya handheld Raman spectrometers are ACT Label certified and enable zero-waste workflows, offering a green choice for raw material identification workflows.

Magnesium, calcium, or zinc stearates are commonly used in pharmaceutical drug manufacturing. While these metal stearates exhibit similar chemical properties, they are not necessarily interchangeable in manufacturing processes. It is critical therefore that they are identified and differentiated at receipt in the warehouse to avoid process disruptions. Accurately differentiating stearate analogs at receipt by Raman spectroscopy has historically been challenging. Given the similarities of the spectra of the compounds, sophisticated chemometric software is often needed to build stearate models that are then used to identify them. This study shows that the Agilent Vaya handheld Raman spectrometer with Spatially Offset Raman Spectroscopy (SORS) can identify metal stearates in their original primary packaging, without the need for complex chemometric software packages. The handheld Vaya Raman enables the selective verification of stearates using a two-criteria decision algorithm combined with the "Analogous Sample" software feature.

Raman spectroscopy is a rapidly expanding field, with modern Raman spectrometers offering labs higher ease of use and sensitivity. Furthermore, combining Raman spectroscopy with scanning electron microscopy (SEM) and fluorescence-lifetime imaging microscopy (FLIM) can enhance the technique for various applications.

The Use of ICP-MS for the Analysis of Challenging Semiconductor Chemicals

Explore in-depth pre-analytical workflow solutions for mastering Li-ion battery elemental analysis.

This note describes using ICP-MS to analyze oral drug products in accordance with the accuracy, precision, and quantitative limits described in the JP, EP, and USP.

In this industry report, a study on certified reference fertilizer materials was performed to prove how the ETHOS UP is optimal for metals analysis.

This note highlights the ability of ICP optical emission spectroscopy to characterize trace elements in high sulfuric acid matrices with good precision and accuracy.

WITec ParticleScout uses white-light microscopy and Raman spectroscopy to find, classify and identify microparticles over large sample areas.

Correlative Raman Microscopy for 2D Materials (New text= 2D materials such as graphene and transition metal dichalcogenides are well-suited to investigation by Raman and SEM. Examples of both are presented in this application note.)

Europe’s preeminent annual conference for Raman microscopy brings the international community together and offers a stage for presenting the field’s latest discoveries.

2D materials such as graphene and transition metal dichalcogenides are well-suited to investigation by Raman and SEM. Examples of both are presented in the following.

Potassium bromate as an oxidizing agent in bread production is a staple, but it also poses health risks due to its classification as a carcinogen, necessitating careful monitoring of its residual levels. This application note reviews the spectrophotometric determination of potassium bromate concentration in bread based on the redox reaction between potassium bromate and promethazine in an acidic environment.

The Raman Rxn4 analyzer for LNG provides accurate measurement of the composition and calorific value of LNG, with 10 times lower uncertainty than GC-vaporizer system.

The European Gas Research Group has undertaken a project to evaluate Raman spectroscopy as an alternative to measure the composition of liquefied natural gas (LNG).

Digestion of oils and plastics can be a challenge even to analytical laboratories. Herein, samples ranging from robust to routine are completely digested in minutes.

This Agilent application note details the use of a Cary 5000 UV-Vis-NIR spectrophotometer with a universal measurement accessory for the optical characterization and reverse-engineering of thin films. It emphasizes the importance of multi-angle spectral photometric data in assessing the optical parameters of thin films, which is crucial for quality control in manufacturing processes.

This Agilent application note discusses the Cary 7000 UMS, a system for mapping coated wafers using UV-Vis spectral reflection and transmission measurements. It introduces a new autosampler for automated, high-resolution mapping of large samples and demonstrates its utility with a zinc tin oxide layer on a sapphire substrate.

The Agilent Cary 5000 UV-Vis-NIR spectrophotometer, equipped with a Praying Mantis diffuse reflectance accessory, is ideal for analyzing catalyst powders. It provides valuable insights into chemical transformations across a broad temperature range, from 20 to 250 °C, enhancing the understanding of catalytic processes.

This eBook provides a deeper dive into the benefits of applying a ‘Total Workflow’ approach to sample prep for elemental analysis and the tools and methods that can be used to achieve those benefits.

Our Breeze Spectrometer Family offers coverage ranges from 400-2500nm

Learn how to apply a ‘Total Workflow’ approach to sample preparation for elemental analysis. Leading to increased lab productivity, better data quality, lower costs, and improved safety.

This white paper offers guidance on selecting the optimal microwave technology for the unique demands of pharmaceutical and dietary supplement matrices, as outlined in USP Chapter <233>. 

In this industry report, a recovery study was performed on certified reference materials and spiked samples to demonstrate the efficacy of ultraWAVE 3 in the preparation of mixed samples from 0.5 g to 2 g in a single digestion run.