Application Notes: General

The ICP-MS Issue 2026

The September/October issue of Spectroscopy is dedicated to ICP-MS, following the technique from the interface region to the clinic. Learn how to keep sampler and skimmer cones performing at their peak, with side-by-side cleaning protocols for Ni, Pt, and Cu-based cones that protect sensitivity and maximize uptime. Discover how helium collision mode turns qualifier ions into a fast, built-in check on multielement data in even the most complex matrices. Then explore the cutting edge, where nanoparticle-tagged immunoassays push biomarker detection below the fg/mL level.

This application note demonstrates the use of Raman spectroscopy to analyze the structural properties of carbon materials. Researchers performed chemical imaging on mechanical pencil refills of varying hardness to map graphite and disorder-related carbon structures at the submicron level. The study highlights Raman’s advantage over elemental and X-ray diffraction analysis for characterizing both crystalline and amorphous carbon materials non-destructively.

Laboratories performing trace elemental analysis are facing growing sample volumes without corresponding increases in staff. Rising electricity and argon costs, complex sample matrices, and stringent detection-limit requirements add to operational pressures. The Avio® 3000 inductively coupled plasma optical emission spectrometer (ICP-OES) addresses these challenges through a ground-up redesign of its plasma generator, optical spectrometer, and detector. Its air-cooled plasma generator eliminates the need for a liquid chiller while reducing argon consumption by up to 50% compared with older helical-coil instruments. A back-side illuminated complementary metal-oxide-semiconductor detector assigns each pixel its own exposure time, increasing throughput by approximately 40% compared with the Avio 550 Max system. The Avio 3000 also demonstrated high-throughput performance under challenging analytical conditions. In wastewater testing using U.S. Environmental Protection Agency Method 200.7 across 33 elements, the system processed 178 samples in 8 hours. Signal drift remained below 10% in a 15% sodium chloride matrix without internal standard correction, while most elements showed relative standard deviations below 1%. Beyond analytical performance, the instrument's design can reduce ongoing operating costs. A cost-of-ownership model estimates that savings from reduced chiller electricity, air conditioning, argon consumption, and maintenance could amount to approximately $7,000 per year, or about $49,000 over a 7-year instrument life.

Explore a semi-automated approach to PFAS analysis in soil designed to meet US EPA Method 1633A performance requirements. The workflow automates extraction and sample clean-up to increase throughput, reduce manual handling and help minimize opportunities for error and PFAS contamination.

See how combustion ion chromatography can be used to determine total organic fluorine in textiles as manufacturers respond to evolving PFAS requirements. This application proof note demonstrates a C-IC workflow using the Cindion Combustion Ion Chromatography System and Dionex Inuvion IC system.

Get an overview of PFAS sources, environmental pathways and analytical approaches across industrial and environmental applications. This roadmap connects routine targeted testing with broader investigational workflows, including sample preparation, LC-MS/MS, combustion ion chromatography and high-resolution mass spectrometry.

See how Professor Lee Ferguson's laboratory at Duke University combines high-resolution mass spectrometry, Compound Discoverer software and advanced cheminformatics to investigate complex PFAS mixtures. The work includes a spectral library of more than 46,000 known and predicted compounds to support identification of known, unexpected and emerging PFAS.

Explore the use of adsorbable organic fluorine and combustion ion chromatography to screen for PFAS in wastewater. This application note presents results from the EPA Method 1621 multi-laboratory collaboration study, including practical guidance for adsorption, combustion, ion chromatography and method implementation.

PFAS testing requirements vary by matrix and analytical goal. See workflows spanning sample preparation, targeted LC-MS/MS analysis, combustion ion chromatography, high-resolution mass spectrometry and data processing for water, soil and other challenging samples. The guide also compares approaches for known PFAS quantitation and unknown screening.

The lab is getting smaller and moving closer to where analysis is actually needed. In "Recent Advancements in Portable and Handheld Spectroscopy," we highlight the miniaturization of analytical equipment, detailing how traditional laboratory-bound instruments have evolved into portable and handheld spectroscopy devices. This exclusive eBook covers chip-scale Raman, field-ready NIR, and AI-assisted XRF, plus the real-world applications driving them.

This guide demonstrates six enzymatic Megazyme test kits on METTLER TOLEDO UV/Vis instruments for measuring acids, alcohols, and sugars in food and beverage production.

Advances in X-Ray Analysis: Techniques, Insights, and Applications brings together five years of coverage on XRF, XRD, XPS, TXRF, micro-XRF, and EDIXS. Explore how handheld XRF is transforming food safety screening, how multimodal X-ray techniques are preserving 26th-Dynasty Egyptian artifacts, what a Saharan meteorite reveals about aubrite mineralogy, and why AI-assisted spectral interpretation is becoming standard in next-gen instrumentation. Nine thematic sections. Two peer-reviewed features. One indispensable download for anyone working in X-ray spectroscopy.

Unlock the future of analytical science and laboratory compliance. Our annual IR Technology and Resource Issue of Spectroscopy delivers essential, real-world solutions to maximize your lab's efficiency, data integrity, and regulatory readiness. Learn how to slash your user acceptance testing (UAT) times by leveraging supplier software validation, master peak positions for tri-, tetra-, and penta-substituted benzene rings with the magazine's acclaimed spectral interpretation workshop. Explore articles on AI-driven chemometrics, non-destructive submicron microplastics imaging, and multimodal forensic fiber differentiation. Whether you are navigating regulatory guidelines, selecting new instrumentation, or conducting advanced materials research, this issue provides the trustworthy insights you need to succeed.

Unlock the future of analytical science and laboratory compliance. Our annual IR Technology and Resource Issue of Spectroscopy delivers essential, real-world solutions to maximize your lab's efficiency, data integrity, and regulatory readiness. Learn how to slash your user acceptance testing (UAT) times by leveraging supplier software validation, master peak positions for tri-, tetra-, and penta-substituted benzene rings with the magazine's acclaimed spectral interpretation workshop. Explore articles on AI-driven chemometrics, non-destructive submicron microplastics imaging, and multimodal forensic fiber differentiation. Whether you are navigating regulatory guidelines, selecting new instrumentation, or conducting advanced materials research, this issue provides the trustworthy insights you need to succeed.

Say goodbye to costly, time-consuming food testing processes. ProxiScout™provides instant and reliable on-site analysis for a wide variety of food items and ingredients, ensuring consistent quality, compliance, and swift decision-making. Integrate with the NeoSpectra portal and experience efficiency and advanced analytics, setting a new standard in food analysis across the supply chain

The ability to accurately measure milk composition is crucial for dairy quality control, ensuring product consistency, and optimizing feed management. The ProxiScout™ handheld NIR scanner provides a rapid, cost-effective, and non-destructive solution for on-site milk analysis. This study evaluates the accuracy and performance of ProxiScout™ in predicting fat, protein, and lactose content in raw milk samples, demonstrating its alignment with ICAR standards.

As trace-level elemental analysis becomes routine, sample preparation has become the primary bottleneck in the analytical workflow. Although ICP-OES and ICP-MS generate results in seconds, digestion remains time-intensive, and incomplete digestion or contamination can compromise data quality. This executive summary examines key considerations for selecting a microwave digestion workflow, comparing rotor-based and single reaction chamber systems across matrix complexity, throughput, contamination control, reagent use, and staffing requirements. It also highlights the application support and digital resources that help laboratories adopt new workflows while maintaining validated methods.

In today's pharmaceutical laboratories, accuracy, reproducibility, and regulatory compliance are nonnegotiable across every stage of analysis. The LAMBDA® 365+ ultraviolet visible (UV/Vis) spectrophotometer is designed to support pharmaceutical laboratories in meeting these requirements. Its dual-beam configuration, accessory options, and temperature control capabilities enable a range of applications, including quality control testing and biomolecule analysis. This paper explores how this system can be paired with Spectrum UV software, which offers both standalone and client–server configurations to support data management and 21 CFR Part 11 compliance. Together, these features contribute to consistent spectroscopic analysis across the instrument lifecycle.