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Atomic Spectroscopy

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Unsolved Problems in Spectroscopy - Part 2

This tutorial addresses the critical issue of analyte specificity in multivariate spectroscopy using the concept of Net Analyte Signal (NAS). NAS allows chemometricians to isolate the portion of the signal that is unique to the analyte of interest, thereby enhancing model interpretability and robustness in the presence of interfering species. While this tutorial introduces the foundational concepts for beginners, it also includes selected advanced topics to bridge toward expert-level applications and future research. The tutorial covers the mathematical foundation of NAS, its application in regression models like partial least squares (PLS), and emerging methods to optimize specificity and variable selection. Applications in pharmaceuticals, clinical diagnostics, and industrial process control are also discussed.

Golden sign outside the United States Department of Government Efficiency (DOGE) © stockyme -chronicles-stock.adobe.com

DOGE-related federal funding cuts have sharply reduced salaries, lab budgets, and graduate support in academia. Researchers view the politically driven shifts in priorities as part of recurring systemic issues in U.S. science funding during administrative transitions. The impact on Federal laboratories has varied, with some seeing immediate effects and others experiencing more gradual effects. In general, there is rising uncertainty over future appropriations. Sustainable recovery may require structural reforms, leaner administration, and stronger industry-academia collaboration. New commentary underscores similar challenges, noting scaled-back graduate admissions, spending freezes, and a pervasive sense of overwhelming stress among faculty, students, and staff. This article addresses these issues for the analytical chemistry community.

James Harrington (right) and Donna Seibert (left), authors of this study. | Image Credit: © James Harrington and Donna Seibert

Spectroscopy sat down with James Harrington of Research Triangle Institute (RTI International) in Research Triangle Park, North Carolina, who was the lead author of this study, as well as coauthor Donna Seibert of Kalamazoo, Michigan. In Part I of our conversation with Harrington and Seibert, they discuss the impact of ICH Q3D and United States Pharmacopeia (USP) <232>/<233> guidelines on elemental impurity analysis and how they designed their study.

A welder in protective gear fuses aluminum pieces with precision, © 69-chronicles-stock.adobe.com

A new dual-spectroscopy approach reveals real-time pollution threats in indoor workspaces. Chinese researchers have pioneered the use of laser-induced breakdown spectroscopy (LIBS) and aerosol mass spectrometry to uncover and monitor harmful heavy metal and dust emissions from soldering and welding in real-time. These complementary tools offer a fast, accurate means to evaluate air quality threats in industrial and indoor environments—where people spend most of their time.

Astronomy concept backdrop. Picture of an atom. | Image Credit: © Sergey Nivens - stock.adobe.com

“Atomic Perspectives,” provides tutorials and updates on new analytical atomic spectroscopy techniques in a broad range of applications, including environmental analysis, food and beverage analysis, and space exploration, to name a few. Here, we present a compilation of some of the most popular columns.

Molecular structures illuminated with a radiant glow in a vivid scientific representation of atomic interactions. Generated with AI. | Image Credit: © BYAI - stock.adobe.com

At Pittcon this year, there will be numerous sessions dedicated to spotlighting the latest research that uses atomic spectroscopy or elemental analysis techniques. We highlight some of these talks below that might pique the interest of spectroscopists and researchers attending the conference this year.