Portable and Handheld Spectroscopy

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Image Credit: © Metrohm
Handheld Raman to Fight Fentanyl—A Crucial New Use for an Established Tool

April 18th 2024

Metrohm has launched a website that details the use of portable Raman spectroscopy instrumentation to detect fentanyl, and other manufacturers are joining the battle too.

silkworm cocoon on green mulberry leaves | Image Credit: © nd700 - stock.adobe.com
Diseased Silkworms Screened Using Portable NIR Spectroscopy

April 9th 2024

Sacramento Farmers Market | Image Credit: © Julia - stock.adobe.com.
Q&A: Portable FT-IR Empowers On-Site Food Quality Assurance

February 1st 2024

Portable Raman Spectrometer | Image Credit: © Forance - stock.adobe.com
Portable Raman Spectrometers: How Small Can They Get?

June 1st 2023

A Brief Survey of Handheld and Portable Instruments Used in Spectroscopy
A Brief Survey of Handheld and Portable Instruments Used in Spectroscopy

November 1st 2020

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Analysis of Organic Compounds in Water Using Unique Concentration–Injection Techniques for Portable GC–MS

May 1st 2017

A simple method for extraction and concentration of trace organic compounds found in water for gas chromatography-mass spectrometry (GC-MS) analysis was developed. The method used 25 and 45 mL glass vials with a 5-10 µm thick polymer coatings for extraction of analytes from 20 and 40 mL water samples, respectively. Analytes were subsequently transferred from the polymer coating into an organic solvent, which was reduced in volume to 200-400 µL for analysis. A 10-20 µL sample from the vial was transferred to a tiny coiled stainless steel wire filament using a micro-syringe, or by dipping the coil into the sample. After air evaporation of the solvent, the coil was inserted into the heated injection port of a portable GC-MS system where the analytes were desorbed. Injection using the coiled wire filament eliminated sample discrimination of high boiling point compounds, and minimized system contamination caused by sample matrix residues. The GC-MS contained a new resistively heated column bundle that allowed elution of low-volatility compounds in less than 4 min. Analyses of organochlorine pesticides, polycyclic aromatic hydrocarbons, polychlorinated biphenyl congeners, pyrethroid insecticides, phthalate esters, and n-alkanes in water and wastewater samples were accomplished for low ppb concentrations in less than 10 min total analysis time.


Developing Portable Raman Spectroscopy Methods for Identification of Raw Materials Used in Pharmaceutical Development and Manufacturing

February 1st 2017

Portable instrumentation for Raman spectroscopy has rapidly evolved over the last decade, where sample testing that once occurred in the laboratory is now executed in the field (e.g. warehouse).   Portable Raman spectroscopy is a powerful technique for the rapid identification of diversely sourced raw materials used in pharmaceutical processing.  In addition to portability; reduced cost, rapid data acquisition and ease of use make this powerful technique attractive and accessible to both expert spectroscopists and non-specialists.  In most cases, the method development can be easily accomplished in the laboratory after which the instrument and methods are transferred to field for sample analysis or warehouse areas for inspection of incoming raw material.  Qualitative Raman methods for identification of raw materials typically utilize spectral libraries for sample to standard comparison.  When developing Raman spectral libraries for raw material identification, great care is required when considering critical factors (e.g. instrument type, Raman capability, container type, container interference, background interference, material variability) that can potentially influence the identity of the material.  This paper discusses portable Raman techniques and approaches for raw material identification, as well as key considerations for developing and validating Raman spectral libraries.