June 25th 2024
A recent review article explored the recent advancements in mass spectrometry (MS) and how it is being applied in pharmaceutical analysis.
Economic Prosperity Drives Spectroscopy Prospects in 2005
March 1st 2005Overall, 2004 was a good year for the laboratory analytical and life science instrument industry. A rebound in industrial demand, steady increases in life science spending, and strong growth in Asia and North America drove instrument systems and aftermarket sales. Similar to last year, 2005 should bring healthy sales growth as many of the end-market and regional drivers of last year continue to fuel demand.
Tech Note - Design Criteria for ICP Spectrometry Using Advanced Optical and CCD Technology (PDF)
The authors describe an ICP detection technology that combines photo-current conversion and a solid-state multichannel detector.
IMS for Cleaning Verification (PDF)
January 2nd 2005The need to verify cleaning between manufacturing runs presents a special challenge to the analytical chemist. In this article, the principles of ion mobility spectrometry are described, its performance is compared to HPLC for the analysis of cleaning validation samples, and findings are presented from a study to establish the feasibility of using IMS in validating a cleaning verification method.
Post-Tableting NIR Analysis: A Look at PAT Applicability to the Output of Solid Dosage Forms (PDF)
January 2nd 2005A majority of current discussion about NIR's applicability to pharmaceutical manufacturing is focused on preparative processes such as granulation, drying, and blending. The author examines different considerations for NIR for the output of the manufacturing line - finished tablet analysis.
PAT, NeSSI, and Sample Conditioning Systems: State of the Technologies and Future Directions (PDF)
January 2nd 2005This article reviews the development of FDA's PAT Initiative along with CPAC's ANSI/ISA-76.00.02 (2002) (NeSSI) development. The intent is to show how the NeSSI components could contribute to the PAT philosophy and physical requirements.
Chemometrics and PAT: What Does It All Mean? (PDF)
January 2nd 2005A paradigm shift is required for chemists and engineers to best utilize chemometrics in their processes. This change demands that one not be too fixated upon ideal textbook thermodynamic models but instead continually check these models using real-time data input and chemometric analysis. The author discusses implementation strategies and the benefits that chemometrics can bring to the process environment.
Considerations for Primary Vacuum Pumping in Mass Spectrometry Systems (PDF)
Mass spectrometry systems have specific vacuum requirements. New developments in oil-free, or dry, primary vacuum pumps have been introduced recently and are discussed in this article with respect to capacity, throughput, and specific pumping requirements for process gases.
Using NIR Spectroscopy as an Integrated PAT Tool (PDF)
December 1st 2004This article summarizes recent efforts by the Duquesne University Center for Pharmaceutical Technology to develop and validate a PAT method using NIR spectroscopy for the on-line prediction of tablet hardness and active pharmaceutical ingredient content.