Mass Spectrometry

The authors discuss the changes that have taken place in the last two decades regarding the users and capabilities of LC–MS.

This article provides an overview of the instrument platforms, tools, and workflow for analyzing pesticides.

In the fourth part of this five-part series, columnist Ken Busch discussed weighted regression analysis as used in QMS. In this final column, he adds an additional explanation.

Data are presented for a pH-adjustable liquid UV-matrix-assisted laser desorption ionization (MALDI) matrix for mass spectrometry analysis. The liquid matrix system possesses high analytical sensitivity within the same order of magnitude as that achievable by the commonly used solid UV-MALDI matrices but with improved spot homogeneity and reproducibility. The pH of the matrix has been adjusted, achieving an on-target pH range of 3.5?8.6, which has allowed for the performance of a tryptic digest within the diluted pH-optimized liquid matrix.

The authors introduce a compact ECD device coupled to a linear ion trap time-of-flight instrument, and use it to analyze protein phosphorylation in both offline and online modes.

In this article, the authors take a look at the identification, synthesis, and characterization of impurities in Ramipril tablets.

This article describes the ability to increase the sensitivity for a target compound in the presence of high-level background impurities by removing the dosing vehicle using a high-field asymmetric waveform ion mobility spectrometry gas-phase separation before mass spectrometry analysis.

Many organic chemicals are difficult to analyze using traditional GC–MS. In this study, the author used LC–MS-MS to analyze a variety of environmental contaminants.

Here, the authors demonstrate the use of a systematized approach to SPE method development and LC–MS-MS analysis.

In the fourth part of a five-part series, columnist Ken Busch discusses factors that might cause deviation from linearity at the upper and lower limits of a calibration curve.

The in-tube extraction technique for determination of volatile organic compounds in water is described.

This article presents GC–TOFMS methods developed to identify several major drug classes and chemical functionalities.

The adoption of MALDI-TOF mass spectrometry for imaging applications is a major recent development in the market. Applications lie squarely in the life sciences area, being primarily in histopathology. The market for MALDI imaging products already accounts for a significant and rapidly growing portion of the aftermarket for MALDI-TOF mass spectrometry.

First developed in the mid-1980s, matrix assisted laser desorption ionization (MALDI) added a complementary mass spectrometry ionization technique to others that were already on the market, such as electrospray ionization (ESI).

Columnist Ken Busch presents the third of a five-part series on quantitative mass spectrometry. In this installment, he focuses on an overview of regression analysis for calibration lines and curves in mass spectrometry.

The concept of portable mass spectrometry has been around for some time, but the realization of such technology has been largely limited until very recently. More than ever before, recent technological advances now make smaller, lighter, and more effective mass spectrometers possible. Such advances will lend themselves to a growing spectrum of applications as well.

In this month's installment, columnist Ken Busch continues his discussion of quantitative mass spectrometry with a look at the "cancel out" claim and some of the statistical underpinnings for the proportional comparison of instrument responses for standard knowns and unknowns.

This tutorial illustrates the most important definitions used in high-resolution mass spectrometry and clarifies the misconceptions surrounding some of the relevant terms used in this field.

In this article, the role of a triple-quadrupole mass spectrometer in performing in vitro studies of compound metabolic stability and identification of Phase I and II metabolites is demonstrated.

The list of acronyms in mass spectrometry published regularly here reflects the writings and conversations of mass spectrometrists, who use a variety of acronyms to describe particular experiments or applications. New applications, with new audiences, bring new technical jargon.

Product Resources - MS

LC?MS software

In addition to expressing his longing for a Star Trek "tricoder," columnist Ken Busch shows that the core processes of ionization, ion dissociation, and mass determination in mass spectrometry are all completed in very short times compared to the overall length of the analysis.

Product Resources - Molecular

Product Resources - Atomic

This month's "Focus on Quality" presents a critique of the GAMP Good Practice Guide. And while columnist Bob McDowall finds much to recommend in the guide, he finds much more cause for concern.

Here the author compares near-infrared to mid-infrared as analytical tool in process management. he weighs the pros and cons of both spectral regions and suggests general applications for which one or the other is better suited.

Acid stills

Mass spectrometer