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Metallomics seeks to understand the metallobiochemistry of cells and organisms in health and disease. This article explains the principle of laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) for imaging applications and highlights its potential to provide additional insights in bioanalysis and metallomics.

Imaging of Trace Elements Using Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry: Emerging New Applications

Robert Thomas has more than 30 years of experience in trace element analysis. He is the principal of his own freelance writing and scientific consulting company, Scientific Solutions, based in Gaithersburg, MD.

For a number of elements, spectroscopic interferences can have a significant impact on the ability to achieve low detection limits in ICP-MS. We investigate the mechanisms in multi-quadrupole ICP-MS that are designed to remove these interferences.

Multi-Quadrupole ICP-MS: Pushing Limits of Detection to the Next Decimal

Inductively coupled plasma–atomic emission spectroscopy (ICP-AES) relies on the use of a peristaltic pump for sample introduction. Here, two conventional peristaltic pumps are compared with a new pump based on the “easy click” principle for the analytical figures of merit.

Comparison of Peristaltic Pumps Used for Sample Introduction in Inductively Coupled Plasma–Atomic Emission Spectroscopy (ICP-AES)

Single-cell analysis is important in biology
and medicine, because it takes into account cell heterogeneity and cellular dynamics, which are governed by cellular crosstalk and the vicinity of cells. Thus, it is of utmost importance to obtain not only information about the heterogeneity of a cell population, but also about their spatial arrangement.

Single-Cell Analysis by ICP-MS—Current Status and Future Trends

Nanomaterials have a tremendous impact on our daily life, but usually in a beneficial way because of their useful properties. 

When Size Matters: ICP-MS Detection of Small Objects

Single-particle inductively coupled plasma–mass spectrometry (spICP-MS) is becoming widely used to measure the number of nanoparticles (or other submicrometer– sized particles) per mL with a particular elemental chemical composition and the average particle size (diameter) or particle size distribution.

Single Particle ICP-MS: From Engineered Nanoparticles to Natural Nanoparticles

There is no doubt that funding for basic science in analytical atomic spectroscopy has waned over the years, and, in reality, barely exists today.

Atomic $pectroscopy

Although not as widespread in terms of units used worldwide as quadrupole-based inductively coupled plasma–mass spectrometry (ICP-MS) equipment, also multicollector ICP-MS (MC-ICP-MS) instrumentation has revolutionized many fields.

Multicollector ICP-MS and Isotope Metallomics

In celebration of Spectroscopy’s 35th Anniversary, leading experts discuss important issues and challenges in analytical spectroscopy.