Near Infrared (NIR) Spectroscopy

November 2006. The authors demonstrate the use of NIR-CI for simultaneous measurement of content uniformity for multiple tablets and discuss some advantages of this approach.

Here the authors determine the content of ecdsterone in the Chinese herb Niuxi using near-infrared diffuse reflection spectroscopy and the partial least squares correlation. Compared to existing methods, they contend that their approach is easier, quicker, cheaper, and less environmentally harmful.

Here the author compares near-infrared to mid-infrared as analytical tool in process management. he weighs the pros and cons of both spectral regions and suggests general applications for which one or the other is better suited.

Tunable diode laser absorption spectroscopy (TDLAS) has evolved from a laboratory specialty technique to the foundation for highly sensitive and specific gas-phase sensors for the process environment. This article discusses two recently developed products, a portable trace gas monitor, and a water vapor flow sensor.

The authors describe implementation and performance of a miniaturized NIR analyzer and associated chemometric techniques applied to the monitoring of a drying process for active pharmaceutical ingredients (APIs).

NIR-CI adds a completely new dimension to conventional NIR spectroscopy.

Encoded photometric technology has the ability to address the demands of modern process applications, including those of the PAT initiative.

This article summarizes recent efforts by the Duquesne University Center for Pharmaceutical Technology to develop and validate a PAT method using NIR spectroscopy for the on-line prediction of tablet hardness and active pharmaceutical ingredient content.

This article summarizes recent efforts by the Duquesne University Center for Pharmaceutical Technology to develop and validate a PAT method using NIR spectroscopy for the on-line prediction of tablet hardness and active pharmaceutical ingredient content.

Near-infrared spectroscopy moves into warehouses to check incoming drug substances, excipients, and packaging materials, and onto the production floor to monitor characteristics such as blend uniformity, moisture content, and dissolution rate.