Application Notes: General

This application note demonstrates the effectiveness of Agilent compact and portable FTIR systems for detecting counterfeit pharmaceuticals with three examples: ethambutol hydrochloride, cephuroxime axetil, and atorvastatin calcium.

This technical note describes features and functionality of Agilent MicroLab software (version 5.2 and later) in combination with SCM and SDA for data management and electronic traceability, which enable customers to implement the guidelines of 21 CFR Part 11.

This note highlights OpenLAB ECM Compliance Pack for UV-Vis Benefits such as efficient data storage and retrieval, security, data integrity and traceability, and 21 CFR Part II Comliance.

This note looks at specific components that require validation; the instrument, software, and validated test methods, and describes the features of the Agilent Cary 8454 UV-Visible system that is designed to meet the requirements of both initial and recurrent validation.

This note describes how the design of the Cary 8454 UV-Vis exceeds performance requirements stipulated by global pharmacopeia guidelines including USP and EP/BP. Configured for compliance, with 21 CFR Part 11, the instrument performs multi wavelength analysis, time-based kinetics assays, and routine QA/QC measurements.

This application note demonstrates how Agilent’s Cary 630 FTIR easily meets the specifications of the US, European, Japanese, Chinese, Indian and International Pharmacopoeia. Its combination of compact size, design, intuitive and regulation-compliant software makes the Cary 630 FTIR an ideal instrument for pharmaceutical quality control.

The Agilent Cary 8454 UV-Visible system is ideal for regulatory Pharma QA/QC applications, and can acquire a complete spectrum in less than 1 second. This technical note outlines both applications-based and technical considerations for choosing a diode array UV-Vis

This application note describes a very sensitive classification method, partial least squares–discriminant analysis (PLS-DA), incorporated in Agilent innovative MicroLab software, to classify and qualify materials of interest with greater sensitivity and specificity than possible with simple library search methods.

Photoluminescence (PL) lifetime measurements in NIR are the key parameters in assessing the optical efficiency of devices involving lanthanides, as well as in quality control during their manufacturing.

PFA cyclonic spray chamber was evaluated for use with a Thermo ElementXR HR-ICP-MS. The signal stability of the cyclonic spray chamber was studied, along with its washout.

Understand how specific design features achieve extreme matrix tolerance and chemical inertness combined with high sensitivity and precision.

Reliability of a low flow glass concentric nebulizer combines with chemical resistance and low elemental background of a PFA concentric nebulizer.

FT-IR microscopy constitutes a very fast and efficient alternative to the well-established staining methods. It allows to analyze biological samples with minimal sample preparation and without the need for any agents for contrast enhancement.

Analysis of trace elements in petrochemical samples is routinely carried out for quality control and process monitoring using protocols set by organizations such as ASTM. However, analysis of these samples is often challenging due to the high matrix and potential for interferences. This executive summary will provide essential information on how to develop robust methods over coming these challenges and ensure excellent results when analyzing trace elements in petrochemicals samples by ICP-OES.

The Milestone UltraWAVE is a bench-top instrument that operates at very high pressures and temperatures, capable of processing large, dissimilar and difficult samples quickly, easily-all without batching. The data shown in this technical note demonstrates that the digestion of samples in the UltraWAVE results in uniformly high analytical data quality, making it the ideal solution for trace metals detection in food.

BaySpec’s PeakFinderTM Raman video probe combines a flexible fiber optic probe with microscope objectives allowing sampling down to several microns. Combined with various benchtop Raman spectrometers, the Raman video probe is a unique micro-Raman system available in 532, 785 or 1064nm excitation and various microscope objectives offering unprecedented flexibility and versatility.

Raman spectroscopy is an important instrument in the arsenal of art conservators and archaeologists. This application note summarizes some recent literature on the selection of portable instruments in this field and also documents some successful work done utilizing background correction to elucidate the composition of some challenging green pigments.

The at-line analysis of gold in impregnated stripping solutions during the electrowinning process is demonstrated. EDXRF is used for analysis of the concentrations of gold in strip solution during the processing of ores, tailings and slags.

Fluorescence spectroscopy is used to investigate museum specimen as a flexible and minimally invasive technique. The photo-physical properties of Egyptian and modern artwork pigments are presented in this application note.

To learn more about Method development for ICP-OES, Spectroscopy Magazine talked with Matthew Cassap, Product Manager ICP-OES, AA, and Trace Elemental Analysis at Thermo Fisher Scientific.

Introducing a new single quadrupole ICP-MS to the range of trace elemental analysis solutions offered by Thermo Scientific. To learn more, Spectroscopy Magazine talked with Shona McSheehy-Ducos, ICP-MS Product Manager, Thermo Fisher Scientific in Bremen, Germany.

Here we demonstrate how PerkinElmer’s PinAAcle™ 900 atomic absorption spectrometer coupled to a FAST Flame sample automation accessory can analyze common nutritional elements in fortified cereals.

Moxtek’s PBS products enable engineers the flexibility to design optical systems optimized for performance, size, and weight for use in projection display, virtual and augmented reality HMD, and HUD systems.

Overcoming the boundary between user-friendliness and the ultimate capability in Raman Imaging is the key to effortlessly manage the image-acquisition and data evaluation at the highest lateral and spectral resolution. This executive summary will explore how the most intricate Raman Imaging experiments can be easily accomplished leading to a greatly improved data quality, ease of use and productivity.

Optimization and follow up of manufacturing process of plastics films are easily achieved using Pulsed RF Glow Discharge Optical Emission Spectrometry. This technique allows the fast detection of defects and presence of contaminants.

Combining SPRi technology with MALDI mass spectrometry on the same surface is a powerful approach for the analysis of biomolecular interactions, allowing measurement of biomolecular interactions by SPRi, and then detection of the retained ligands by MALDI mass spectrometry directly from the sensor surface.

This appnote shows the benefits of using pulsed RF GDOES for the analysis of films containing nanoparticles

This appnote shows the application of GDOES to materials used in Solid Oxide Fuel Cells, which are based on chemical oxidation of the fuel rather than its combustion, offering high efficiency without forming air pollutants.

Raman spectroscopy has been used to analyze the process of micro-encapsulation of flavors. This contribution shows the example of distribution of limonene and quantification of its content within the micro-particles.