Application Notes: General

Overcoming the boundary between user-friendliness and the ultimate capability in Raman Imaging is the key to effortlessly manage the image-acquisition and data evaluation at the highest lateral and spectral resolution. This executive summary will explore how the most intricate Raman Imaging experiments can be easily accomplished leading to a greatly improved data quality, ease of use and productivity.

Combining SPRi technology with MALDI mass spectrometry on the same surface is a powerful approach for the analysis of biomolecular interactions, allowing measurement of biomolecular interactions by SPRi, and then detection of the retained ligands by MALDI mass spectrometry directly from the sensor surface.

Surface Plasmon Resonance (SPR) is an optical technique that offers label-free biomolecular analyses, providing information on kinetic processes (association and dissociation), binding affinity, analyte concentration and real time molecule detection. It has become a powerful tool for the analysis of biomolecular events involved in drug development, cancer research, and antibody screening

Since the function of a protein is closely related to its structure, the structural analysis of proteins and peptides is becoming increasingly important to assist in deciphering bioactivity. CD measurements are easy to obtain, and small sample volumes can be used. Additionally, conformational changes of proteins and peptides due to pH, temperature and external ligands can also be obtained.

Patented UltraWAVE SRC technology goes beyond traditional digestion, offering greater capabilities for the most difficult sample types. High-performance stainless steel construction allows for higher pressures and temperatures, while disposable vessels eliminate the need to assemble, disassemble or clean between processing. Just as important, dissimilar samples can be processed simultaneously, saving time and money.

Spectral Systems has developed its Diamond XP-BBAR™ coating. With our coating the SNR is about 30% better through most of the analysis region of a typical FT-IR instrument.

Closed vessel microwave digestion has proven to be an effective alternative to traditional sample prep techniques with methods of fast, complete digestions, clean environment, and full recovery of volatile compounds.

Modern paints and varnishes are complex mixtures and the optimization of the material properties is an important task. One of the most essential variables is the curing which should in most cases take place in a reasonably short time span that can range from a fraction of a second to many days. It is difficult to evaluate the degree of the curing and its completeness by visual inspection. Therefore, an unbiased and reliable quantitative analysis is needed in quality control but also in R&D to optimize the varnish or the curing method respectively.