Application Notes: General

Surface Plasmon Resonance (SPR) is an optical technique that offers label-free biomolecular analyses, providing information on kinetic processes (association and dissociation), binding affinity, analyte concentration and real time molecule detection. It has become a powerful tool for the analysis of biomolecular events involved in drug development, cancer research, and antibody screening

Exposure to warm/humid conditions may cause pharmaceutical formulations to undergo change in hydration level, affecting properties and/or efficiency of the drug. Raman spectroscopy, with a temperature and humidity controller can mimic harsh conditions, monitor properties of ingredients and track modifications induced by environmental changes.

Time‐resolved Fluorescence can analyze potential health benefits from antioxidant activity of curcumin, found in turmeric. Curcuminoids, weakly fluorescent in aqueous solution, show quantum yield increases upon interaction with a protein, such as human serum albumin.

Locate particles, generate size/shape statistics, select particles based on size/shape, and acquire Raman spectra. Easily locate and identify particulate matter, including pharmaceutical materials, trace forensic evidence, geological rock/mineral particles, and airborne contaminants trapped on filters

Since the function of a protein is closely related to its structure, the structural analysis of proteins and peptides is becoming increasingly important to assist in deciphering bioactivity. CD measurements are easy to obtain, and small sample volumes can be used. Additionally, conformational changes of proteins and peptides due to pH, temperature and external ligands can also be obtained.

Protein secondary structure during thermal unfolding and aggregation is readily acquired using IR spectroscopy and a temperature-controlled Mid-IR transmission accessory.

Patented UltraWAVE SRC technology goes beyond traditional digestion, offering greater capabilities for the most difficult sample types. High-performance stainless steel construction allows for higher pressures and temperatures, while disposable vessels eliminate the need to assemble, disassemble or clean between processing. Just as important, dissimilar samples can be processed simultaneously, saving time and money.

Up-conversion finds important applications from biological labels to sensors and solar cells. This application note elucidates the experimental requirements for the characterisation of up-conversion using lanthanides as a model material.

This paper compares the performance of the Agilent OneNeb Series 2 nebulizer with conventional glass concentric and inert nebulizers recommended by PerkinElmer for use with the Optima Series ICP-OES systems.

Spectral Systems is the world’s leading supplier of beamsplitter components our coatings can eliminate undesirable spectral features.

Spectral Systems’ Super-Sealed™ Liquid Cells are designed and manufactured for leak free precision quantitative analysis and maximum reproducibility.

Spectral Systems’ Infrared Windows are available in a wide variety of sizes, shapes and materials for measurement and operation in the infrared spectral domain.

A novel approach in Raman spectroscopy enables bulk material analysis without the need for specialized equipment. Enhanced Raman reflection can be integrated into current processes using available instrumentation, enabling real-time process measurement and control.

Closed vessel microwave digestion has proven to be an effective alternative to traditional sample prep techniques with methods of fast, complete digestions, clean environment, and full recovery of volatile compounds.

Download this application note to learn how to rapidly and accurately determine arsenic in apple juice using HPLC/ICP-MS.

Modern paints and varnishes are complex mixtures and the optimization of the material properties is an important task. One of the most essential variables is the curing which should in most cases take place in a reasonably short time span that can range from a fraction of a second to many days. It is difficult to evaluate the degree of the curing and its completeness by visual inspection. Therefore, an unbiased and reliable quantitative analysis is needed in quality control but also in R&D to optimize the varnish or the curing method respectively.

Thermal decomposition provides valuable information about the chemical composition of a material. Although thermal gravimetric analysis (TGA) measures small weight losses during a heating ramp, it cannot identify the chemicals corresponding to the weight loss.

Used everywhere from bar code scanners to sophisticated single-molecule microscopes, lasers are powerful and cost-effective light sources for applications spanning basic research to consumer entertainment.

The new Savillex PFA Cyclonic Spray Chamber is the first inert chamber with the traditional shape of a glass cyclonic, and is also the first translucent inert chamber.

Ancient Roman builders designed maritime concrete harbor structures to remain intact in the aggressive seawater environment for very long periods of time.

Milestone's UltraWAVE microwave digestion system with single reaction chamber (SRC) technology, enables the simultaneous digestion of up of to 22 different sample types and chemistries at temperatures and pressures as high as 300 ?C and 199 bar.

The permitted sulfur limit in fuel oils has been decreased to 10 ppm in many regions.

Grazing angle Ge ATR spectroscopy is extremely sensitive to monolayers and thin films on high refractive index substrates such as Si.

A broadband polarizing beamsplitter (PBS) cube was developed using embedded Moxtek Nanowire grid polarizer technology.

Raman measurement on microscopic inclusions in fluorescent materials requires the ability to measure in small volumes, excellent throughput, and long wavelength excitation such as 1064 nm for fluorescence reduction.

The thermal treatment of a grafted Sn-SiO2 catalyst was monitored in situ using diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS).

The "inelastic scattering of light," or Raman effect, was observed in practice for the first time in 1928 by C.V. Raman for which he was awarded the Nobel Prize in 1930.

A method for quantifying the percent sulfate associated with sodium lauryl sulfate (also referred to as sodium dodecyl sulfate) and sodium laureth sulfate (also referred to as sodium lauryl ether sulfate) found in commonly used commercial body care products using FT-IR attenuated total reflectance (ATR) spectroscopy is outlined.