Application Notes: General

This application note shows the ability of PerkinElmer's Avio® 500 ICP-OES to achieve RSDs < 0.1% for matrix elements in simulated battery materials, thanks to its ability to perform true simultaneous measurements.

This work illustrates the ability of PerkinElmer’s Avio® 200 hybrid scanning ICP-OES to accurately and reliably measure impurities in aluminum at levels specified in the London Metal Exchange.

In this complimentary eBook “Are you measuring ICP-OES samples more than once? – How to stop time-wasting remeasurements”, we present the facts about the cost of remeasuring ICP-OES samples.

Calculating the impact of remeasuring ICP-OES samples Instrument-related problems that cause remeasurements and what to do about them Finding and addressing sample-related problems that cause remeasurements

Mid-IR spectroscopy with an instrument such as the Ocean MZ5 can help to streamline the production of isopropyl alcohol and other complex solvents.

Fluorine’s NMR properties provide the chemist both additional tools as well as additional challenges in regards to complete structure elucidation.

Renishaw’s RA802 Pharmaceutical Analyser was used to detect small amounts of different polymorphic forms of an active pharmaceutical ingredient in a generic drug powder.

This application note demonstrates analysis of elemental impurities, such as arsenic, in vitamin B12 according to USP chapter , using triple quadrupole ICP-MS.

Glass Expansion’s new HydraMist spray chamber can be simultaneously used to determine As, Se, Sb and Hg via hydride generation, in addition to the determination of non-hydride forming elements using conventional pneumatic nebulization. The performance of the HydraMist was evaluated on an Agilent 5100 SVDV ICP-OES, and, when paired with a SeaSpray nebulizer, the detection limits for the hydride forming elements were improved between 15- and 50-fold without compromising the analytical performance of the non-hydride forming elements.

This application note demonstrates how the PlasmaQuant MS provides low detection limits, accurate results and long-term stability analyzing volatile solvents.

• QuEChERS vs. a modified method with the Geno/Grinder for pesticide analysis • Stable isotope analysis for the testing of food product origins • Arsenic testing in hard ciders

• Achieving low detection limits by minimizing contamination in sample prep • Economic approach to reducing reagent blanks in ICP-OES and ICP-MS • Automated acid reflux cleaning system for maximum efficiency

• How to balance compliance needs with creating useful SOPs. • Tips and tricks for ensuring consistency. • Why and how you should test your SOPs

Reliable TOC analysis using the NPOC method with TIC control, high throughput by parallel purge and analysis, comparing catalytic combustion with UV-chemical oxidation.

This note looks at incidences of polymorphism in drug development including advantages and challenges.

• Raman spectroscopy of streamlining pharma QC and formulation development • Implementing transmission Raman for fast content uniformity testing • Through-container identity verification of polysorbates 20, 40, 60, and 80

• Even with a relatively light sample load of 250 samples per week, remeasuring 15% of them adds up to 2 weeks per year. • That’s 2 weeks you could be using for something more value-adding (and less boring).

Celldex utilized MMS to successfully observe the HOS of monoclonal antibody samples in complex buffer systems including excipients such as amino acids and sugars.

BSA samples analyzed at different concentrations to study heat induced thermal denaturation. Results show excellent reproducibility between sample replicates, concentrations.