Application Notes: General

This application note provides insights for the transition of optical nanostructures from design to volume NIL manufacturing using wire grid polarizer as an example.

Mid-IR spectroscopy with an instrument such as the Ocean MZ5 can help to streamline the production of isopropyl alcohol and other complex solvents.

Fluorine’s NMR properties provide the chemist both additional tools as well as additional challenges in regards to complete structure elucidation.

Renishaw’s RA802 Pharmaceutical Analyser was used to detect small amounts of different polymorphic forms of an active pharmaceutical ingredient in a generic drug powder.

This application note demonstrates analysis of elemental impurities, such as arsenic, in vitamin B12 according to USP chapter , using triple quadrupole ICP-MS.

Glass Expansion’s new HydraMist spray chamber can be simultaneously used to determine As, Se, Sb and Hg via hydride generation, in addition to the determination of non-hydride forming elements using conventional pneumatic nebulization. The performance of the HydraMist was evaluated on an Agilent 5100 SVDV ICP-OES, and, when paired with a SeaSpray nebulizer, the detection limits for the hydride forming elements were improved between 15- and 50-fold without compromising the analytical performance of the non-hydride forming elements.

This application note demonstrates how the PlasmaQuant MS provides low detection limits, accurate results and long-term stability analyzing volatile solvents.

• QuEChERS vs. a modified method with the Geno/Grinder for pesticide analysis • Stable isotope analysis for the testing of food product origins • Arsenic testing in hard ciders

• Achieving low detection limits by minimizing contamination in sample prep • Economic approach to reducing reagent blanks in ICP-OES and ICP-MS • Automated acid reflux cleaning system for maximum efficiency

Reliable TOC analysis using the NPOC method with TIC control, high throughput by parallel purge and analysis, comparing catalytic combustion with UV-chemical oxidation.

This note looks at incidences of polymorphism in drug development including advantages and challenges.

• Raman spectroscopy of streamlining pharma QC and formulation development • Implementing transmission Raman for fast content uniformity testing • Through-container identity verification of polysorbates 20, 40, 60, and 80

• Even with a relatively light sample load of 250 samples per week, remeasuring 15% of them adds up to 2 weeks per year. • That’s 2 weeks you could be using for something more value-adding (and less boring).

Celldex utilized MMS to successfully observe the HOS of monoclonal antibody samples in complex buffer systems including excipients such as amino acids and sugars.

BSA samples analyzed at different concentrations to study heat induced thermal denaturation. Results show excellent reproducibility between sample replicates, concentrations.

Novel IR technique, microfluidic modulation spectroscopy, to address the requirements of development laboratories for high-quality higher-order structure assessment

This webinar presents a study mimicking the viral inactivation low pH hold used in purification of mAbs.

A new bioanalytical technique called microfluidic modulation spectroscopy is used to probe the backbone structure of IDE in the absence and presence of ATP and insulin.

This whitepaper explores MMS as a high-resolution method for the determination of protein HOS.

This webinar shows a demonstration of some of the key advantages of MMS for assessment of higher-order structure in therapeutic antibodies and antibody-drug conjugates.

An IgG1 sample was analyzed at different concentrations. The results in this poster from Pfizer, demonstrate high repeatability and precision of the diffAU spectra.