To investigate its DNA-binding properties, a GST-ZNF191(243–368) fusion protein was used in fluorescence quenching studies with two DNA sequences (GGAGGGTGGTTA and GAAATAATGTTA).

Researchers have demonstrated a non-invasive method using milk and near-infrared spectroscopy combined with Aquaphotomics to accurately detect Paratuberculosis in dairy cattle. The technique offers faster, more sensitive diagnosis than traditional methods.

Researchers at the University of the Basque Country, along with Català Restauradors S.L. analyzed the emergence of soluble salts on mural paintings in the vault of the Valencia Cathedral, using Raman and micro-energy-dispersive X-ray fluorescence spectroscopy combined with ion chromatography.

Researchers have demonstrated that visible and near-infrared spectroscopy, combined with chemometric and aquaphotomic analysis, can accurately classify and quantify aflatoxin contamination in white and yellow maize, offering a faster, non-destructive alternative to traditional methods.

A recent study tested a new mitochondria-targeting fluorescent probe, known as Mito-CDM, to see if it can improve the monitoring of mitochondrial viscosity.

Researchers have developed a rapid, non-invasive screening method for esophageal squamous cell carcinoma (ESCC) using near-infrared spectroscopy and aquaphotomics. The approach analyzes plasma water patterns, achieving over 95% accuracy in distinguishing patients from healthy controls

A recent study demonstrated that combining hyperspectral imaging with multivariate curve resolution can non-invasively detect and monitor intestinal necrosis in acute mesenteric ischemia, offering a promising tool for earlier diagnosis and improved patient outcomes.

Metabolite identification is critical in drug development, with mass spectrometry (MS) as the primary tool, but limited in full structural elucidation. Infrared ion spectroscopy (IRIS) overcomes some of these limitations by combining MS sensitivity with IR-based structural fingerprints, enabling characterization without reference standards. Spectroscopy spoke to Giel Berden regarding applications in metabolite identification by determining the site of glucuronidation and phase I oxidation in selected drug molecules.

This Icons of Spectroscopy article profiles Lester W. Strock, whose innovative research in crystal chemistry and spectroscopy bridged fundamental science and applied geochemistry.

Top articles published this week include a video highlighting some of the icons of spectroscopy and a news article about using machine learning to quantify uncertainty in spectroscopic analyses.

This explainer video describes the role that reflection and emission spectroscopy play in characterizing rocky exoplanets.

In this edition of “Inside the Laboratory,” George Shields, a professor of chemistry at Furman University and the founder and director of the Molecular Education and Research Consortium in Undergraduate Computational ChemistRY (MERCURY), discusses the goal of MERCURY and some of its most recent projects

Analytica USA, debuting September 10–12 in Columbus, Ohio, combines a trade exhibition with a scientific conference for analytical science.

A new study demonstrates how a machine learning technique, quantile regression forest, can provide both accurate predictions and sample-specific uncertainty estimates from infrared spectroscopic data. The work was applied to soil and agricultural samples, highlighting its value for chemometric modeling.

In a recent press release, Horiba, an analytical and measurement technology company, announced the release of its Aqualog-Next A-TEEM Spectrometer.

This explainer video highlights how energy-dispersive inelastic X-ray scattering (EDIXS) can be used to discriminate between different stamps.

A recent study conducted by researchers from Northwestern Polytechnical University explored how to improve laser-induced breakdown spectroscopy (LIBS) for analyzing complex mineral samples

A new study demonstrates that infrared spectroscopy combined with chemometric modeling offers a fast, cost-effective way to classify plant-based milk alternatives and detect compositional variability, particularly in almond beverages.

This Icons of Spectroscopy Series article features Infrared pioneer Earle Keith Plyler (1897–1976), who transformed molecular spectroscopy—building precision techniques, reference data, and instruments that set enduring methods and standards at the National Bureau of Standards (NBS, now NIST). As a teacher and mentor, he established a generation of leaders in molecular spectroscopy.

The Winter Conference on Plasma Spectrochemistry will convene in Tucson, Arizona, from January 11–17, 2026.

The Icons of Spectroscopy series shines a spotlight on the pioneers whose work laid the foundation for modern analytical science.

In a recent review article, a team of researchers from Shanghai Jiao Tong University explored how to improve the monitoring of drugs and metabolites in biomedical research and clinical settings.

This tutorial contrasts classical analytical error propagation with modern Bayesian and resampling approaches, including bootstrapping and jackknifing. Uncertainty estimation in multivariate calibration remains an unsolved problem in spectroscopy, as traditional, Bayesian, and resampling approaches yield differing error bars for chemometric models like PLS and PCR, highlighting the need for deeper theoretical and practical solutions.

Learn how to troubleshoot FT-IR spectroscopy. From noisy spectra to ATR errors, discover four common FT-IR problems and simple fixes.

Top articles published this week include a video about the structural complexity of polyethylene, a news story about using near-infrared (NIR) and X-ray fluorescence (XRF) to classify coal types, and a look at microplastic analysis.

This explainer video highlights how spectroscopic sensors can help improve health monitoring applications.

Researchers from Brazil have developed an improved method combining infrared and Raman spectroscopic techniques to better identify and characterize microplastics. This integrated approach enhances accuracy in distinguishing various polymer types and provides refined spectral analysis crucial for environmental studies.