October 14th 2024
A recent study published in Sustainability highlighted the utility of Raman spectroscopy in the development of digital agriculture.
Applications of Confocal Raman Spectroscopy and Imaging in the Medical Device Industry
June 1st 2020Raman spectroscopy and imaging techniques are well suited for the characterization of surfaces, interfaces, and coatings to support research, development, and manufacturing of medical devices. Here, we describe applications in surface modifications and coatings, differentiation of drug polymorphs, degradation of biomaterials, and forensic identification of unknown materials.
In Situ Enhancement of Microplastic Raman Signals in Water Using Ultrasonic Capture
June 1st 2020Of the 78 million tons of plastic packaging manufactured every year, approximately one-third ends up in the ocean, the air, and most foods and beverages. To monitor the proliferation of these plastics, an ultrasonic capture method is demonstrated that produces a 1500-fold enhancement of Raman signals of microplastics in water.
A Corrosive Liquid Investigated by Diamond ATR Infrared Spectroscopy
February 1st 2020Because of their corrosive properties, corrosive lipids are challenging to analyze by ATR-FT-IR. Repeated and prolonged analysis can damage many ATR crystals. Diamond ATR is a better choice for such applications than other ATR crystal materials like ZnSe and Ge. This application note examines a corrosive liquid as it becomes progressively more concentrated using diamond ATR.
Bioreactor Fermentation Monitoring with Raman Spectroscopy
February 1st 2020Raman spectroscopy’s high analytical selectivity and insensitivity to water is well suited for process monitoring in biotechnology. Here we explore the fermentation of glucose, a common feedstock, with a commonly used microorganism, yeast. Applying multivariate tools, we can monitor the main reactants and products with high sensitivity: glucose, ethanol, and carbon dioxide.
QTRam for Content Uniformity Analysis of Low-Dose Pharmaceutical Tablets
February 1st 2020Compressed tablet is the most common form of orally administered drug. The United States Pharmacopeia (USP) chapter <905> requires that dosage uniformity of such products containing less than 25 mg or less than 25% active pharmaceutical ingredients (API) by weight must be analyzed for content uniformity, which is based on the assay of each API in a number of individual dosage units.
Tracking Photocuring via ATR-FT-IR with Illumination through the ATR Element
February 1st 2020The utility of the GladiATR diamond ATR, modified with an internal liquid light guide to illuminate the sample from underneath the ATR element, was explored to analyze the photo-polymerization of carbitol acrylate at 405 nm using 1 wt% TPO.
Gallium Nitride Quality and Stress Field Characterization with 3D Confocal Raman Imaging
February 1st 2020The quality and stress field properties of gallium nitride (GaN) crystals must be investigated in order to refine production processes. 3D Confocal Raman microscopy is uniquely capable of the chemical c and visualizing strain in this material.
Raman Thermometry: Understanding the Mathematics to Better Design Raman Measurements
December 1st 2019Raman measurements can be used to infer the temperature of a material based on the Stokes and anti-Stokes band signal strengths, and by applying a predefined mathematical relationship. In reality, the temperature, Raman shift, and laser excitation wavelength all interact, and should be considered to better understand these measurements.
Gary M. Hieftje’s Legacy: Fifty Years of Scientific Contributions
December 1st 2019A famous and admired professor of analytical chemistry, Gary M. Hieftje, is officially retiring. He has been a prominent faculty member at Indiana University for 50 years, and a beloved mentor, colleague, and friend to many. In this special feature, we take a look at his many contributions, and his broad impact on the field.
The 2019 Emerging Leader in Molecular Spectroscopy Award
October 1st 2019Ishan Barman, this year’s Emerging Leader in Molecular Spectroscopy award recipient, leads a research team combining spectroscopy, imaging, and chemometrics to seek greater understanding of the pathological changes of human cells and tissues.
Diamond ATR Study of Worn Surfaces on Metal
September 1st 2019Tribology-the study of friction, wear, and lubrication-is important in mechanical, electromechanical, and biological systems. Changes in materials due to abrasion, friction, lubrication, erosion, and corrosion result in failures of the moving components during use. These effects are usually minimized by careful surface finish design and lubrication. Recycling and refinishing surfaces can extend the lifetimes of components. By examining worn surfaces, better methods can be developed to prevent wear. This applications note uses infrared spectroscopy to study tribology changes in steel.
Measurement of the Temperature Dependence of Water Using a Near-Infrared Raman Spectrograph
June 1st 2019The spectral behavior of water is studied using Raman with an NIR spectrograph and dual wavelength lasers for measurements of both the fingerprint and the OH stretching regions. Raman spectra are recorded between 5 ⁰C and 80 ⁰C, and treated with both band-fitting and the 2D-COS algorithm revealing improved insights into the spectral behavior of water.