August 25th 2025
This tutorial contrasts classical analytical error propagation with modern Bayesian and resampling approaches, including bootstrapping and jackknifing. Uncertainty estimation in multivariate calibration remains an unsolved problem in spectroscopy, as traditional, Bayesian, and resampling approaches yield differing error bars for chemometric models like PLS and PCR, highlighting the need for deeper theoretical and practical solutions.
Using Thermostable Raman Interaction Profiling (TRIP) For Protein Binding Screening
March 1st 2024Narangerel Altangerel, Zhenhuan Yi, and Marlan Scully of Texas A&M University recently used TRIP to analyze eight protein–ligand systems. Spectroscopy recently spoke to these three researchers about their findings and what the implications are for high-throughput drug screening.
Reviewing the Impact of Raman Spectroscopy on Crop Quality Assessment: An Interview with Miri Park
February 1st 2024Miri Park of the Fraunhofer Institute for Environmental, Safety, and Energy Technologies is examining how Raman spectroscopy could aid non-destructive sensing in agricultural science. Recently, Park sat down with Spectroscopy to discuss micro-Raman spectroscopy's role in assessing crop quality, particularly secondary metabolites, across different contexts (in vitro, in vivo, and in situ), while suggesting future research for broader application possibilities.
Raman Spectroscopy to Detect Traumatic Brain Injuries: An Interview with Pola Goldberg Oppenheimer
January 10th 2024This interview with Pola Goldberg Oppenheimer of the University of Birmingham highlights new research her team is working on that includes a Raman-based system for detecting early traumatic brain injuries.
SHERLOC's Precision Unveiled: Calibration Method Enhances Raman Spectroscopy on Mars
November 20th 2023Researchers at NASA's Johnson Space Center, led by Ryan S. Jakubek, have unveiled a novel calibration method in Applied Spectroscopy that enhances the precision of Raman measurements conducted by the SHERLOC instrument on the Perseverance rover, providing a clearer and more accurate representation of intrinsic Raman spectral bandwidths on Mars.