Mass Spectrometry

Thin-layer chromatography (TLC) is a widely used technique for the rapid examination of compound purity. The amount of qualitative information, however, is limited to the retention factor of compounds. The technique described here enables the direct determination of TLC plates by MALDI MS.

The 52nd annual ASMS conference will be held May 23-27, 2004 in Nashville, TN. Like its predecessors, this year's meeting will be geared toward promoting and disseminating knowledge of MS.

New developments in matrix-assisted laser desorption ionization (MALDI) technology enable decoupling of the ionization source from the time-of-flight mass analyzer for operation at atmospheric pressure (AP-MALDI). This technique also can be integrated with other types of mass analyzers, such as the ion trap.

A handheld spectrometer is the latest weapon used in the ongoing battle between the spirits industry and costly counterfeit products.

NIR-CI adds a completely new dimension to conventional spectroscopy.

Because tautomers often cannot be isolated as single isomers, spectroscopists should always anticipate possible tatomeric forms that can complicate the interpretation of their spectra. This involves the use of spectral databases and tautomerically enabled search algorithms.

This year will resemble last in terms of market growth, with a projected continuation of trends seen in 2003.

This installment provides a wrap-up of the 18th International Forum for Process Analytical Chemistry.

Engineer's innovative mycotoxin-detection and sorting system utilizes spectroscopy methods to detect aflatoxin and fumonisin in yellow corn

The authors discuss progress in near-field IR microspectroscopy using a photothermal probe and show how it can be applied to the spectroscopic characterization of real-world samples.

This column discusses training and system documentation, and how to write a validation summary report.

The authors discuss progress in near-field IR microspectroscopy using a photothermal probe and show how it can be applied to the spectroscopic characterization of real-world samples.

The authors discuss progress in near-field IR microspectroscopy using a photothermal probe and show how it can be applied to the spectroscopic characterization of real-world samples.

This installment examines one of the key differences between the Near-IR and Mid-Range IR and highlights a couple of applications where Mid-IR can be effectively employed as a process analytical technology (PAT).

The author discusses informatics applications in MS-MS analyses that specifically allow greater differentiation of meaningful signal from chemical noise.

A new quadupole ICP-MS instrument has been designed to improve the sensitivity of this elemental analysis technique.

The author discusses how the physical realm of the atmospheric ionization source -- materials, gas, and heat dynamics -- and manipulating the ionization modes themselves perhaps are the current forefront of technological innovation.

The authors discuss how the dynamics associated with laser ablation solid sampling systems ensures greater analytical precision and accuracy for ICP-MS/OES trace element analysis.

Inductively coupled plasma-mass spectrometry (ICP-MS) is a powerful technique for elemental and isotopic analysis that combines the efficiency and ease of use of the ICP component with the sensitivity and selectivity of MS.

The fourth installment in the continuing series concentrates on issues that are amenable to mathematical analysis.

Careful consideration of the dynamics associated with laser ablation solid sampling systems ensures greater analytical precision and accuracy for ICP-MS/OES element analysis.

Editorial index for articles published in 2003.

This series about derivatives in spectroscopy continues with a discussion about some of the practical aspects of computing the derivative.

This article is the third installment in a series about a novel spectrofluorometric method that allow for in vivo observation of the division of chlorplast populations in leaves of Arabidopsis thalania.

A diagrammatic view of the concept of detection limits is presented that effectively shows its relationship to the reproducibility of measurements on the blank.